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Chemical Compound Review:

Miserotoxin (2R,3S,4S,5R,6R)-2- (hydroxymethyl)-6-(3...

Synonyms:

Majak, W. et al., Pass, M.A. et al., Benn, M.H. et al.

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Disease relevance of Miserotoxin

The low toxicity of miserotoxin was attributed to a low level of microbial hydrolysis [1].

High impact information on Miserotoxin

In-vitro biotransformation of 3-nitropropanol (miserotoxin aglycone) by horse liver alcohol dehydrogenase [2].
The reticulo-rumen was the major site of absorption for the miserotoxin aglycone but the abomasum and the small intestine also had the capacity to absorb NPOH [3].
NPA was not detected in the gastrointestinal tract during miserotoxin digestion [1].
Miserotoxin, a component of certain legumes, was relatively innocuous given orally (LD50 greater than 2.5 g/kg) but NPOH (LD50 = 77 mg/kg) was at least 10 times more toxic [1].

Chemical compound and disease context of Miserotoxin

The toxicity of miserotoxin (3-nitro-1-propyl-beta-D-glucoside) and its aglycone, NPOH, were compared in rats [1].

References

Toxicity of miserotoxin and its aglycone (3-nitropropanol) to rats. Majak, W., Pass, M.A., Madryga, F.J. Toxicol. Lett. (1983) [Pubmed]
In-vitro biotransformation of 3-nitropropanol (miserotoxin aglycone) by horse liver alcohol dehydrogenase. Benn, M.H., McDiarmid, R.E., Majak, W. Toxicol. Lett. (1989) [Pubmed]
Absorption of 3-nitropropanol and 3-nitropropionic acid from the digestive system of sheep. Pass, M.A., Majak, W., Muir, A.D., Yost, G.S. Toxicol. Lett. (1984) [Pubmed]

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