High impact information on LOMOFUNGIN

• Termination of induction by inducer removal, addition of the ribonucleic acid synthesis inhibitor lomofungin, or resuspension of a culture of organisms containing temperature-sensitive rna1 gene products in a medium at 35 degrees C resulted in loss of ability for continued arginase synthesis with half-lives of 5.5, 3.8, and 4.5 min, respectively [1].
• Existence of two levels of repression in the biosynthesis of methionine in Saccharomyces cerevisiae: effect of lomofungin on enzyme synthesis [2].
• Lomofungin staining revealed that nuclear division was also arrested by these drugs [3].
• The use of the antibiotic lomofungin for demonstration of nuclei and chromosomes in liver yeast cells and protoplasts [4].

References