Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

CHEMBL460440 2-[(2E,6E,10E,14E,18E)- 3,7,11,15,19,23...

Synonyms: NSC-693182, NSC693182, AC1NS4ME, 2-Hexaprenylhydroquinone, 2-hexaprenyl-hydroquinone

Loya, S. et al.

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Disease relevance of HPH

Mode of inhibition of HIV reverse transcriptase by 2-hexaprenylhydroquinone, a novel general inhibitor of RNA-and DNA-directed DNA polymerases [1].
A natural compound from the Red Sea sponge Ircinia sp., 2-hexaprenylhydroquinone (HPH), has been shown to be a general inhibitor of retroviral reverse transcriptases (from HIV-1, HIV-2 and murine leukaemia virus) as well as of cellular DNA polymerases (Escherichia coli DNA polymerase I, and DNA polymerases alpha and beta) [1].

References

Mode of inhibition of HIV reverse transcriptase by 2-hexaprenylhydroquinone, a novel general inhibitor of RNA-and DNA-directed DNA polymerases. Loya, S., Rudi, A., Kashman, Y., Hizi, A. Biochem. J. (1997) [Pubmed]

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