Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

NSC-29428 (Z)-3-(1H-indol-3-yl)prop-2- enoic acid

Synonyms: NSC-137806, NSC-612862, NSC29428, LS-82241, NSC137806, ...

Matchett, W.H. et al., Davis, P.J. et al., Herzog, N.K. et al., Spindler, K.R. et al.

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Disease relevance of Indoleacrylic acid

After induction with indoleacrylic acid, fusion proteins accumulated stably in the E. coli cells [1].
Chromobacterium violaceum (ATCC 12472) metabolizes N-carbobenzoxyl-L-tryptophan into its 2', 3'-dehydro-derivative, and indole-3-propionic acid into indole-3-acrylic acid [2].

High impact information on Indoleacrylic acid

Upon induction of trpE with indoleacrylic acid, large amounts of trpE-v-rel fusion proteins were produced by the bacteria carrying these recombinant plasmids [3].
Tryptophan synthase of Neurospora crassa was purified to electrophoretic homogeneity from the wild type strain 74A which had been derepressed by the presence of 0.5 mM indoleacrylic acid in the growth medium [4].

References

Analysis of adenovirus transforming proteins from early regions 1A and 1B with antisera to inducible fusion antigens produced in Escherichia coli. Spindler, K.R., Rosser, D.S., Berk, A.J. J. Virol. (1984) [Pubmed]
Metabolism of N-carbobenzoxyl-L-tryptophan by Chromobacterium violaceum. Davis, P.J., Gustafson, M., Rosazza, J.P. Biochim. Biophys. Acta (1975) [Pubmed]
Expression of the oncogene of avian reticuloendotheliosis virus in Escherichia coli and identification of the transforming protein in reticuloendotheliosis virus T-transformed cells. Herzog, N.K., Bose, H.R. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
The subunit structure of tryptophan synthase from Neurospora crassa. Matchett, W.H., DeMoss, J.A. J. Biol. Chem. (1975) [Pubmed]

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