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Disease relevance of Chromobacterium


High impact information on Chromobacterium


Chemical compound and disease context of Chromobacterium

  • Purification and partial characterization of an amino acid alpha,beta- dehydrogenase, L-tryptophan 2',3'-oxidase from Chromobacterium violaceum [11].
  • FK228 (formerly FR901228) was recently isolated from Chromobacterium violaceum as a potent antitumor agent and its biologic target protein was identified as histone deacetylase (HDAC) [12].
  • Steady-state kinetic analysis of pterin-dependent phenylalanine hydroxylase from Chromobacterium violaceum indicated that the enzyme follows a partially ordered reaction mechanism [13].
  • Identification of metal ligands in Cu(II)-inhibited Chromobacterium violaceum phenylalanine hydroxylase by electron spin echo envelope modulation analysis of histidine to serine mutations [14].
  • The Chromobacterium violaceum activity assay illustrates that reactions between 3-oxo acylated homoserine lactone molecules and oxidized halogens do occur despite the presence of biofilm components at much greater concentrations [15].

Biological context of Chromobacterium


Anatomical context of Chromobacterium


Gene context of Chromobacterium


Analytical, diagnostic and therapeutic context of Chromobacterium


  1. Cloning and expression of Chromobacterium violaceum phenylalanine hydroxylase in Escherichia coli and comparison of amino acid sequence with mammalian aromatic amino acid hydroxylases. Onishi, A., Liotta, L.J., Benkovic, S.J. J. Biol. Chem. (1991) [Pubmed]
  2. Phagocyte NADPH oxidase, but not inducible nitric oxide synthase, is essential for early control of Burkholderia cepacia and chromobacterium violaceum infection in mice. Segal, B.H., Ding, L., Holland, S.M. Infect. Immun. (2003) [Pubmed]
  3. Production of acyl-homoserine lactone quorum-sensing signals by gram-negative plant-associated bacteria. Cha, C., Gao, P., Chen, Y.C., Shaw, P.D., Farrand, S.K. Mol. Plant Microbe Interact. (1998) [Pubmed]
  4. Impact of violacein-producing bacteria on survival and feeding of bacterivorous nanoflagellates. Matz, C., Deines, P., Boenigk, J., Arndt, H., Eberl, L., Kjelleberg, S., Jürgens, K. Appl. Environ. Microbiol. (2004) [Pubmed]
  5. Glucose-6-phosphate dehydrogenase deficiency, neutrophil dysfunction and Chromobacterium violaceum sepsis. Mamlok, R.J., Mamlok, V., Mills, G.C., Daeschner, C.W., Schmalstieg, F.C., Anderson, D.C. J. Pediatr. (1987) [Pubmed]
  6. Molecular mechanism of violacein-mediated human leukemia cell death. Ferreira, C.V., Bos, C.L., Versteeg, H.H., Justo, G.Z., Durán, N., Peppelenbosch, M.P. Blood (2004) [Pubmed]
  7. Phenylalanine hydroxylase from Chromobacterium violaceum. Uncoupled oxidation of tetrahydropterin and the role of iron in hyroxylation. Chen, D., Frey, P.A. J. Biol. Chem. (1998) [Pubmed]
  8. L-tryptophan 2',3'-oxidase from Chromobacterium violaceum. Substrate specificity and mechanistic implications. Genet, R., Bénetti, P.H., Hammadi, A., Ménez, A. J. Biol. Chem. (1995) [Pubmed]
  9. Phenylalanine hydroxylase from Chromobacterium violaceum. Purification and characterization. Nakata, H., Yamauchi, T., Fujisawa, H. J. Biol. Chem. (1979) [Pubmed]
  10. Toward PKU enzyme replacement therapy: PEGylation with activity retention for three forms of recombinant phenylalanine hydroxylase. Gámez, A., Wang, L., Straub, M., Patch, M.G., Stevens, R.C. Mol. Ther. (2004) [Pubmed]
  11. Purification and partial characterization of an amino acid alpha,beta- dehydrogenase, L-tryptophan 2',3'-oxidase from Chromobacterium violaceum. Genet, R., Denoyelle, C., Ménez, A. J. Biol. Chem. (1994) [Pubmed]
  12. Histone deacetylase inhibitor FK228 inhibits tumor angiogenesis. Kwon, H.J., Kim, M.S., Kim, M.J., Nakajima, H., Kim, K.W. Int. J. Cancer (2002) [Pubmed]
  13. Mechanistic studies on phenylalanine hydroxylase from Chromobacterium violaceum. Evidence for the formation of an enzyme-oxygen complex. Pember, S.O., Johnson, K.A., Villafranca, J.J., Benkovic, S.J. Biochemistry (1989) [Pubmed]
  14. Identification of metal ligands in Cu(II)-inhibited Chromobacterium violaceum phenylalanine hydroxylase by electron spin echo envelope modulation analysis of histidine to serine mutations. Balasubramanian, S., Carr, R.T., Bender, C.J., Peisach, J., Benkovic, S.J. Biochemistry (1994) [Pubmed]
  15. Reaction of acylated homoserine lactone bacterial signaling molecules with oxidized halogen antimicrobials. Borchardt, S.A., Allain, E.J., Michels, J.J., Stearns, G.W., Kelly, R.F., McCoy, W.F. Appl. Environ. Microbiol. (2001) [Pubmed]
  16. Phenylalanine hydroxylase from Chromobacterium violaceum is a copper-containing monooxygenase. Kinetics of the reductive activation of the enzyme. Pember, S.O., Villafranca, J.J., Benkovic, S.J. Biochemistry (1986) [Pubmed]
  17. L-Canavanine made by Medicago sativa interferes with quorum sensing in Sinorhizobium meliloti. Keshavan, N.D., Chowdhary, P.K., Haines, D.C., González, J.E. J. Bacteriol. (2005) [Pubmed]
  18. Role of the second coordination sphere residue tyrosine 179 in substrate affinity and catalytic activity of phenylalanine hydroxylase. Zoidakis, J., Sam, M., Volner, A., Han, A., Vu, K., Abu-Omar, M.M. J. Biol. Inorg. Chem. (2004) [Pubmed]
  19. Violacein biotransformation by basidiomycetes and bacteria. Bromberg, N., Durán, N. Lett. Appl. Microbiol. (2001) [Pubmed]
  20. Genotyping of Chromobacterium violaceum isolates by recA PCR-RFLP analysis. Scholz, H.C., Witte, A., Tomaso, H., Al Dahouk, S., Neubauer, H. FEMS Microbiol. Lett. (2005) [Pubmed]
  21. Cell-free biosynthesis of arphamenine A. Okuyama, A., Ohuchi, S., Tanaka, T., Aoyagi, T., Umezawa, H. Biochem. Int. (1986) [Pubmed]
  22. Structural comparison of bacterial and human iron-dependent phenylalanine hydroxylases: similar fold, different stability and reaction rates. Erlandsen, H., Kim, J.Y., Patch, M.G., Han, A., Volner, A., Abu-Omar, M.M., Stevens, R.C. J. Mol. Biol. (2002) [Pubmed]
  23. Cloning, molecular analysis, and expression of the polyhydroxyalkanoic acid synthase (phaC) gene from Chromobacterium violaceum. Kolibachuk, D., Miller, A., Dennis, D. Appl. Environ. Microbiol. (1999) [Pubmed]
  24. Action of FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum no. 968, on Ha-ras transformed NIH3T3 cells. Ueda, H., Nakajima, H., Hori, Y., Goto, T., Okuhara, M. Biosci. Biotechnol. Biochem. (1994) [Pubmed]
  25. beta-Lactamase activity in Chromobacterium violaceum. Farrar, W.E., O'dell, N.M. J. Infect. Dis. (1976) [Pubmed]
  26. Sequence analysis and functional characterization of the violacein biosynthetic pathway from Chromobacterium violaceum. August, P.R., Grossman, T.H., Minor, C., Draper, M.P., MacNeil, I.A., Pemberton, J.M., Call, K.M., Holt, D., Osburne, M.S. J. Mol. Microbiol. Biotechnol. (2000) [Pubmed]
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