Disease relevance of NCU08409.1

• Most amino acid residues essential for catalytic activity in the tryptophan synthase of Salmonella typhimurium are conserved [1].

High impact information on NCU08409.1

• Tryptophan synthase of Neurospora crassa was purified to electrophoretic homogeneity from the wild type strain 74A which had been derepressed by the presence of 0.5 mM indoleacrylic acid in the growth medium [2].
• The deduced amino acid sequence shows 72.6% similarity to the tryptophan synthase of Neurospora crassa [1].
• The predicted secondary structure of sheep liver serine hydroxymethyltransferase was similar to that of the observed structure of tryptophan synthase, another pyridoxal 5'-phosphate containing enzyme, suggesting that sheep liver serine hydroxymethyltransferase might have a similar pyridoxal 5'-phosphate binding domain [3].

References