Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AC1NSDFO 8-(7-hydroxy-2-oxo-chromen-6- yl)-7-(7...

Synonyms: NSC-291853, NSC291853

Law, D.J. et al., Dajani, A.S. et al., Wipf, P. et al., Hao, J.J. et al., Wipf, P. et al.

Wipf, Halter,

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Disease relevance of Viridin

Substances that interfere with action of viridin B, a Streptococcus mitis bacteriocin [1].
Interactions between Neisseria sicca and viridin B, a bacteriocin produced by Streptococcus mitis [2].

High impact information on Viridin

Of various body fluids tested, serum, saliva, and leukocyte lysate interfered with viridin B [1].
Oxygen consumption by actively growing N. sicca cultures ceased immediately upon exposure to viridin B [2].
Viridin, a basic protein of approximately 65 kDa as determined by SDS-PAGE, inhibits the growth of the cotton pathogen Verticillum dahliae, the IC50 being 6 microM [3].
Recent synthetic and biological studies of the viridin class of steroidal furans have revealed multiple opportunities for fundamental discoveries as well as advanced drug design [4].
A series of viridin analogs was prepared from wortmannin by nucleophilic ring opening at C(20) and evaluated against the signaling kinases PI-3-kinase and mTOR [5].

References

Substances that interfere with action of viridin B, a Streptococcus mitis bacteriocin. Dajani, A.S., Veres, C.M., Law, D.J. Infect. Immun. (1978) [Pubmed]
Interactions between Neisseria sicca and viridin B, a bacteriocin produced by Streptococcus mitis. Law, D.J., Dajani, A.S. Antimicrob. Agents Chemother. (1978) [Pubmed]
Isolation and characterization of viridin, a new 65 kDa antifungal protein from the mould Trichoderma viride. Hao, J.J., Geng, C., Xie, W., Gong, Z., Liu, W.Y., Wang, E. Biol. Chem. (1999) [Pubmed]
Chemistry and biology of wortmannin. Wipf, P., Halter, R.J. Org. Biomol. Chem. (2005) [Pubmed]
Synthesis and biological evaluation of synthetic viridins derived from C(20)-heteroalkylation of the steroidal PI-3-kinase inhibitor wortmannin. Wipf, P., Minion, D.J., Halter, R.J., Berggren, M.I., Ho, C.B., Chiang, G.G., Kirkpatrick, L., Abraham, R., Powis, G. Org. Biomol. Chem. (2004) [Pubmed]

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