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Chemical Compound Review:

AC1LBRUD 17-ethanoyl-17-hydroxy- 6,10,13-trimethyl-2...

Synonyms: AGN-PC-00HTL4, MLS002639162, SMR001548609, NCGC00183122-01

Huang, Y. et al., Kwok, S. et al.

Kwok, Selby, McElduff, Laing, Mackness, Mackness, Prais, Morgan, Yates, Durrington, Sci,

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High impact information on medroxyprogesterone

To attempt to understand the lack of benefit in these trials, we have examined the effects of MP and two other progestogens, the less androgenic desogestrel (DG) and the more androgenic norethisterone (NE), on cardiovascular risk factors against a background of oestrogen therapy [1].
OBJECTIVE: Medroxyprogesterone (MP) was used as the progestogen in randomized clinical trials of postmenopausal hormone replacement on cardiovascular risk [1].
MP could delay the ulceration and the corneas treated with MP appeared to have better transparency than the other groups [2].
TEM showed disrupted corneal stroma in all three groups, with thinner scar tissue in the MP group [2].

Anatomical context of medroxyprogesterone

The OPD values from the central corneas from alkali-injured eyes were generally lower than normal during the first 4 weeks and then gradually recovered to the normal level or above, except for the posterior stroma of the MP-treated eyes [2].

Analytical, diagnostic and therapeutic context of medroxyprogesterone

The fibril diameters did not change significantly 3 days and 1 week after the alkali burns (27.1+/-2.3 nm in the control group, 27.3+/-2.2 nm in the SIMP group and 27.7+/-2.1 nm in the MP group) and there were no differences compared with 29.7+/-1.7 nm of the normal cornea (P>0.05) [2].

References

Progestogens of varying androgenicity and cardiovascular risk factors in postmenopausal women receiving oestrogen replacement therapy. Kwok, S., Selby, P.L., McElduff, P., Laing, I., Mackness, B., Mackness, M.I., Prais, H., Morgan, J., Yates, A.P., Durrington, P.N., Sci, F.M. Clin. Endocrinol. (Oxf) (2004) [Pubmed]
Anaylsis of birefringence during wound healing and remodeling following alkali burns in rabbit cornea. Huang, Y., Meek, K.M., Ho, M.W., Paterson, C.A. Exp. Eye Res. (2001) [Pubmed]

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