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Chemical Compound Review

arsorite     trioxidoarsane

Synonyms: arsenite(3-), Arsenite ions, AG-E-03148, CHEMBL1231071, CHEBI:29866, ...
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Disease relevance of trioxidoarsane

  • Cytokines induced the appearance of an NF-kappaB complex as shown in gel retardation assays; however, induction of the HSR by Ars partially prevented cytokine-induced formation of this band while hyperthermia had a more complete inhibition [1].

High impact information on trioxidoarsane


Associations of trioxidoarsane with other chemical compounds

  • In the present study, we investigated the effect of tetraarsenic oxide (As4O6, 2,4,6,8,9,10-Hexaoxa-1,3,5,7-tetraarsatricyclo[,7]decane) upon induction of apoptosis in arsenic trioxide (diarsenic oxide, As2O3) resistant U937 leukemic cells [4].


  1. Heat shock response inhibits cytokine-inducible nitric oxide synthase expression in rat hepatocytes. de Vera, M.E., Kim, Y.M., Wong, H.R., Wang, Q., Billiar, T.R., Geller, D.A. Hepatology (1996) [Pubmed]
  2. Comparison of diarsenic oxide and tetraarsenic oxide on anticancer effects: Relation to the apoptosis molecular pathway. Chang, H.S., Bae, S.M., Kim, Y.W., Kwak, S.Y., Min, H.J., Bae, I.J., Lee, Y.J., Shin, J.C., Kim, C.K., Ahn, W.S. Int. J. Oncol. (2007) [Pubmed]
  3. Diarsenic and tetraarsenic oxide inhibit cell cycle progression and bFGF- and VEGF-induced proliferation of human endothelial cells. Woo, S.H., Park, M.J., An, S., Lee, H.C., Jin, H.O., Lee, S.J., Gwak, H.S., Park, I.C., Hong, S.I., Rhee, C.H. J. Cell. Biochem. (2005) [Pubmed]
  4. Tetraarsenic oxide induces apoptosis in U937 leukemic cells through a reactive oxygen species-dependent pathway. Park, I.C., Park, M.J., Woo, S.H., Lee, H.C., An, S., Gwak, H.S., Lee, S.H., Hong, S.I., Bae, I.J., Seo, K.M., Rhee, C.H. Int. J. Oncol. (2003) [Pubmed]
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