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Gene Review

Hspa1a  -  heat shock 70kD protein 1A

Rattus norvegicus

Synonyms: HSP72, Hsp70-1, Hspa1, Hspa1b
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Disease relevance of Hspa1a

  • Striatal Hsp70 mRNA increased about 2-fold over control levels at 16 hr after AMPH-induced hyperthermia, and was the only Hsp species to significantly increase in response to AMPH [1].
  • The exposure of the animals to in vivo heat stress was shown to induce the synthesis of otherwise non-existing Hsp72, rendering Hsc70 level unchanged in comparison to unstressed controls [2].
  • Exercise, antioxidants, and HSP72: protection against myocardial ischemia/reperfusion [3].
  • Characterization of spinal HSP72 induction and development of ischemic tolerance after spinal ischemia in rats [4].
  • HSP72 appears to play a crucial protective role in modulating the gene expression controlled by NF-kappaB in sepsis [5].

Psychiatry related information on Hspa1a


High impact information on Hspa1a

  • Expression of Hsp 110, inducible Hsp 70, and Hsp 25 was greater in the hyperosmotic papilla than the isosmotic cortex but was not affected by the animal's hydration state [10].
  • These data demonstrate that glucocorticoids protect intestinal epithelial cells against oxidant-induced stress by inducing hsp72 [11].
  • Dexamethasone treatment also significantly induces hsp72 protein expression in rat intestinal mucosal cells in vivo [11].
  • Antisense hsp72 cDNA transfection of IEC-18 cells abolishes the dexamethasone-induced hsp72 response, without significantly affecting constitutive expression of its homologue, hsc73 [11].
  • Dexamethasone stimulates a time- and dose-dependent response in hsp72 protein expression that parallels its effects on cell viability [11].

Chemical compound and disease context of Hspa1a


Biological context of Hspa1a


Anatomical context of Hspa1a


Associations of Hspa1a with chemical compounds

  • Low thyroxine could account for diminished HSP72 synthesis via lower heat production and thermoregulatory set point [12].
  • CsA treatment in Con rats had no effects on muscle mass, fiber size, MHC composition, and Hsp72 or CaN levels [20].
  • This study investigated if SLH induces in vivo HSP72 expression and whether in vitro HSP72 induction by sodium arsenite (NaArs) alters intracellular signal transduction and cytokine production similar to SLH [21].
  • SLH mphi had more HSP72 protein before and after LPS compared with shams [21].
  • Like SLH, mphi with induced HSP72 expression, have an attenuated TNF response [21].

Regulatory relationships of Hspa1a


Other interactions of Hspa1a

  • In vitro HSP72 induction is associated with increased p38 phosphorylation [21].
  • Protein-damaging stresses activate c-Jun N-terminal kinase via inhibition of its dephosphorylation: a novel pathway controlled by HSP72 [27].
  • Glucocorticoid hormone receptor exists in the cytoplasm of target cells in the form of dynamic multiprotein heterocomplexes with heat shock proteins Hsp90 and Hsp70, and additional components of the molecular chaperone machinery [19].
  • The 70-kDa heat shock proteins (Hsp70), including the cognates (Hsc70), are molecular chaperones that prevent misfolding and aggregation of polypeptides in cells under both normal and stressed conditions [28].
  • As an example of single gene analysis, the RT1-linked heat shock-inducible heat shock genes Hsp70-1 and Hsp70-2 have been studied [29].

Analytical, diagnostic and therapeutic context of Hspa1a


  1. Changes in mRNA levels for heat-shock/stress proteins (Hsp) and a secretory vesicle associated cysteine-string protein (Csp1) after amphetamine (AMPH) exposure. Bowyer, J.F., Davies, D.L. Ann. N. Y. Acad. Sci. (1999) [Pubmed]
  2. Intracellular localization of constitutive and inducible heat shock protein 70 in rat liver after in vivo heat stress. Cvoro, A., Korać, A., Matić, G. Mol. Cell. Biochem. (2004) [Pubmed]
  3. Exercise, antioxidants, and HSP72: protection against myocardial ischemia/reperfusion. Hamilton, K.L., Staib, J.L., Phillips, T., Hess, A., Lennon, S.L., Powers, S.K. Free Radic. Biol. Med. (2003) [Pubmed]
  4. Characterization of spinal HSP72 induction and development of ischemic tolerance after spinal ischemia in rats. Cizkova, D., Carmel, J.B., Yamamoto, K., Kakinohana, O., Sun, D., Hart, R.P., Marsala, M. Exp. Neurol. (2004) [Pubmed]
  5. In vivo heat shock protein assembles with septic liver NF-kappaB/I-kappaB complex regulating NF-kappaB activity. Chen, H.W., Kuo, H.T., Wang, S.J., Lu, T.S., Yang, R.C. Shock (2005) [Pubmed]
  6. Habitual physical activity facilitates stress-induced HSP72 induction in brain, peripheral, and immune tissues. Campisi, J., Leem, T.H., Greenwood, B.N., Hansen, M.K., Moraska, A., Higgins, K., Smith, T.P., Fleshner, M. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2003) [Pubmed]
  7. The heat shock/stress response in focal cerebral ischemia. Nowak, T.S., Jacewicz, M. Brain Pathol. (1994) [Pubmed]
  8. MK-801 and ketamine induce heat shock protein HSP72 in injured neurons in posterior cingulate and retrosplenial cortex. Sharp, F.R., Jasper, P., Hall, J., Noble, L., Sagar, S.M. Ann. Neurol. (1991) [Pubmed]
  9. Effect of neonatal chronic stress on expression of Hsp70 and oestrogen receptor alpha in the rat oviduct during development and the oestrous cycle. Mariani, M.L., Ciocca, D.R., González Jatuff, A.S., Souto, M. Reproduction (2003) [Pubmed]
  10. In vivo regulation of MAP kinases in Ratus norvegicus renal papilla by water loading and restriction. Wojtaszek, P.A., Heasley, L.E., Berl, T. J. Clin. Invest. (1998) [Pubmed]
  11. Dexamethasone protection of rat intestinal epithelial cells against oxidant injury is mediated by induction of heat shock protein 72. Urayama, S., Musch, M.W., Retsky, J., Madonna, M.B., Straus, D., Chang, E.B. J. Clin. Invest. (1998) [Pubmed]
  12. beta-Adrenergic signaling and thyroid hormones affect HSP72 expression during heat acclimation. Maloyan, A., Horowitz, M. J. Appl. Physiol. (2002) [Pubmed]
  13. Potential role for heat shock protein 72 in antagonizing cerebral vasospasm after rat subarachnoid hemorrhage. Nikaido, H., Tsunoda, H., Nishimura, Y., Kirino, T., Tanaka, T. Circulation (2004) [Pubmed]
  14. Selective stimulation of Hsp27 and alphaB-crystallin but not Hsp70 expression by p38 MAP kinase activation. Kato, K., Ito, H., Kamei, K., Iwamoto, I. Cell Stress Chaperones (1999) [Pubmed]
  15. Gene therapy with HSP72 is neuroprotective in rat models of stroke and epilepsy. Yenari, M.A., Fink, S.L., Sun, G.H., Chang, L.K., Patel, M.K., Kunis, D.M., Onley, D., Ho, D.Y., Sapolsky, R.M., Steinberg, G.K. Ann. Neurol. (1998) [Pubmed]
  16. Heat shock response inhibits cytokine-inducible nitric oxide synthase expression in rat hepatocytes. de Vera, M.E., Kim, Y.M., Wong, H.R., Wang, Q., Billiar, T.R., Geller, D.A. Hepatology (1996) [Pubmed]
  17. Restriction fragment length polymorphism of the major histocompatibility complex-linked heat shock protein 70 (Hsp70) genes of the rat. Rothermel, E., Walter, L., Hedrich, H.J., Günther, E. J. Exp. Anim. Sci. (1994) [Pubmed]
  18. Heat shock protein 70 is able to prevent heat shock-induced resistance of target cells to CTL. Dressel, R., Elsner, L., Quentin, T., Walter, L., Günther, E. J. Immunol. (2000) [Pubmed]
  19. Hyperthermic stress stimulates the association of both constitutive and inducible isoforms of 70 kDa heat shock protein with rat liver glucocorticoid receptor. Cvoro, A., Matić, G. Int. J. Biochem. Cell Biol. (2002) [Pubmed]
  20. Calcineurin and heat shock protein 72 in functionally overloaded rat plantaris muscle. Oishi, Y., Ogata, T., Ohira, Y., Taniguchi, K., Roy, R.R. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  21. Heat shock protein (HSP72) and p38 MAPK involvement in sublethal hemorrhage (SLH)-induced tolerance. Carter, Y., Liu, G., Stephens, W.B., Carter, G., Yang, J., Mendez, C. J. Surg. Res. (2003) [Pubmed]
  22. Benign focal ischemic preconditioning induces neuronal Hsp70 and prolonged astrogliosis with expression of Hsp27. Currie, R.W., Ellison, J.A., White, R.F., Feuerstein, G.Z., Wang, X., Barone, F.C. Brain Res. (2000) [Pubmed]
  23. Gene transfer of HSP72 protects cornu ammonis 1 region of the hippocampus neurons from global ischemia: influence of Bcl-2. Kelly, S., Zhang, Z.J., Zhao, H., Xu, L., Giffard, R.G., Sapolsky, R.M., Yenari, M.A., Steinberg, G.K. Ann. Neurol. (2002) [Pubmed]
  24. Ecto-5'-nucleotidase plays a role in the cardioprotective effects of heat shock protein 72 in ischemia-reperfusion injury in rat hearts. Sakaguchi, T., Sawa, Y., Kitakaze, M., Suzuki, K., Nishimura, M., Kaneda, Y., Matsuda, H. Cardiovasc. Res. (2000) [Pubmed]
  25. Constitutive expression of HSP 72 in swine heart. Locke, M., Tanguay, R.M., Ianuzzo, C.D. J. Mol. Cell. Cardiol. (1996) [Pubmed]
  26. Expression of heat shock protein, HSP72, in the guinea pig and rat cochlea after hyperthermia: immunochemical and in situ hybridization analysis. Dechesne, C.J., Kim, H.N., Nowak, T.S., Wenthold, R.J. Hear. Res. (1992) [Pubmed]
  27. Protein-damaging stresses activate c-Jun N-terminal kinase via inhibition of its dephosphorylation: a novel pathway controlled by HSP72. Meriin, A.B., Yaglom, J.A., Gabai, V.L., Zon, L., Ganiatsas, S., Mosser, D.D., Zon, L., Sherman, M.Y. Mol. Cell. Biol. (1999) [Pubmed]
  28. Crystal structure of the C-terminal 10-kDa subdomain of Hsc70. Chou, C.C., Forouhar, F., Yeh, Y.H., Shr, H.L., Wang, C., Hsiao, C.D. J. Biol. Chem. (2003) [Pubmed]
  29. Genomic and funtional aspects of the rat MHC, the RT1 complex. Dressel, R., Walter, L., Günther, E. Immunol. Rev. (2001) [Pubmed]
  30. Age and attenuation of exercise-induced myocardial HSP72 accumulation. Demirel, H.A., Hamilton, K.L., Shanely, R.A., Tümer, N., Koroly, M.J., Powers, S.K. Am. J. Physiol. Heart Circ. Physiol. (2003) [Pubmed]
  31. Luminal bacterial flora determines physiological expression of intestinal epithelial cytoprotective heat shock proteins 25 and 72. Arvans, D.L., Vavricka, S.R., Ren, H., Musch, M.W., Kang, L., Rocha, F.G., Lucioni, A., Turner, J.R., Alverdy, J., Chang, E.B. Am. J. Physiol. Gastrointest. Liver Physiol. (2005) [Pubmed]
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