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Chemical Compound Review: 

alaninate     2-aminopropanoate

Synonyms: alanine anion, CHEBI:32439, AC1NUU04
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High impact information on alanine

  • Alkaline or enzymic hydrolysis of 5a gave phosphomonoester alaninate 14, a putative product of intracellular metabolism [1].
  • A series of low molecular weight organic gelator (LMOG) gel systems sensitive to alkaline/acidic stimuli was established by employing amino acid derivatives of cholesterol as "latent" gelators, which are cholesteryl glycinate (1), cholesteryl L-alaninate, cholesteryl D-alaninate, cholesteryl L-phenyl alaninate, and cholesteryl D-phenyl alaninate [2].
  • Alaproclate (2-(4-chlorophenyl)-1,1-dimethyl 2-aminopropanoate) (0.01-0.5 mmol/l) reduced (IC50 = 0.1 mmol/l) and at about 0.5 mmol/l completely blocked the electrically evoked 3H-acetylcholine secretion [3].

References

  1. Phosphodiester amidates of unsaturated nucleoside analogues: synthesis and anti-HIV activity. Winter, H., Maeda, Y., Uchida, H., Mitsuya, H., Zemlicka, J. J. Med. Chem. (1997) [Pubmed]
  2. Amino acid derivatives of cholesterol as "latent" organogelators with hydrogen chloride as a protonation reagent. Li, Y., Liu, K., Liu, J., Peng, J., Feng, X., Fang, Y. Langmuir : the ACS journal of surfaces and colloids. (2006) [Pubmed]
  3. Effects of alaproclate, potassium channel blockers, and lidocaine on the release of 3H-acetylcholine from the guinea-pig ileum myenteric plexus. Alberts, P., Ogren, S.O. Pharmacol. Toxicol. (1989) [Pubmed]
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