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Chemical Compound Review:

AC1NUVW8 8-(dicyclopropylmethyl)-1- methyl-3-propyl...

Synonyms: [11C]MPDX

Fukumitsu, N. et al., Ishiwata, K. et al., Noguchi, J. et al.

Ishiwata, Nariai, Kimura, Oda, Kawamura, Ishii, Senda, Wakabayashi, Shimada, Fukumitsu, Ishii, Kimura, Oda, Sasaki, Mori, Ishiwata,

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Disease relevance of 8-(dicyclopropylmethyl)-1-methyl-3-propyl-7H-purine-2,6-quinone

The radiation absorbed-dose by [11C]MPDX in humans estimated from the tissue distribution in mice was low enough for clinical use, and the acute toxicity and mutagenicity of MPDX were not found [1].

High impact information on 8-(dicyclopropylmethyl)-1-methyl-3-propyl-7H-purine-2,6-quinone

Autoradiography with [11C]MPDX ex vivo demonstrated decreased A1 receptor binding in the superior colliculus of rats deprived of retino-collicular fibers by contralateral eye enucleation [2].
The binding of [11C]MPDX evaluated quantitatively as the distribution volume by a graphical analysis was high in the striatum and thalamus, and low in the cerebellum [3].
The distribution pattern of [11C]MPDX was coincident with that of adenosine A1 receptors in vitro reported previously, and was different from those of blood flow and [18F]FDG [3].

References

Preclinical studies on [11C]MPDX for mapping adenosine A1 receptors by positron emission tomography. Ishiwata, K., Nariai, T., Kimura, Y., Oda, K., Kawamura, K., Ishii, K., Senda, M., Wakabayashi, S., Shimada, J. Annals of nuclear medicine. (2002) [Pubmed]
Evaluation of carbon-11 labeled KF15372 and its ethyl and methyl derivatives as a potential CNS adenosine A1 receptor ligand. Noguchi, J., Ishiwata, K., Furuta, R., Simada, J., Kiyosawa, M., Ishii, S., Endo, K., Suzuki, F., Senda, M. Nucl. Med. Biol. (1997) [Pubmed]
Imaging of adenosine A1 receptors in the human brain by positron emission tomography with [11C]MPDX. Fukumitsu, N., Ishii, K., Kimura, Y., Oda, K., Sasaki, T., Mori, Y., Ishiwata, K. Annals of nuclear medicine. (2003) [Pubmed]

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