Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Glyfoline 1,6-dihydroxy-2,3,4,5- tetramethoxy-10...

Synonyms: CHEMBL88259, AG-H-29729, SureCN9348448, AC1NUJ0E, CTK3E8920, ...

Su, T.L. et al., Su, T.L. et al.

Su, Lin, Chen, Huang, Su, Huang, Wang, Wu, Lin,

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High impact information on Glyfoline

Pure EM morphology of NPC cells after glyfoline treatment revealed the similar morphological change of mitochondria [1].
The mechanism of action, leakage of cytochrome c from mitochondria into cytosol, for the antineoplastic compound glyfoline was examined [2].
However, no similar changes were detected in fibroblasts and peripheral lymphocytes after glyfoline treatment suggesting that glyfoline has a higher affinity for tumor cells than for normal cells [2].

Biological context of Glyfoline

These findings indicate that the binding site of glyfoline in NPC is the inner membrane of the mitochondria, suggesting that B-Gly can be used as a marker for glyfoline localization [1].
Additionally, our current studies revealed that glyfoline induced apoptotic changes and arrested cell cycle procession at the G2/M phase in nasopharyngeal carcinoma (NPC) [2].
Cytochrome C release induces apoptosis of nasopharyngeal carcinoma (NPC) by antitumor glyfoline [2].

References

Synthesis of biotinylated glyfoline for immunoelectron microscopic localization. Su, T.L., Lin, C.T., Chen, C.H., Huang, H.M. Bioconjug. Chem. (2000) [Pubmed]
Cytochrome C release induces apoptosis of nasopharyngeal carcinoma (NPC) by antitumor glyfoline. Su, T.L., Huang, H.M., Wang, C.K., Wu, H.C., Lin, C.T. Planta Med. (2005) [Pubmed]

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