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Chemical Compound Review

ACMC-20mohj     5-chloro-1-[4-fluoro-5...

Synonyms: SureCN11890294, AC1L1TRN, CTK8G6647, AC1Q3H9D, Uridine,5-chloro-2',3'-dideoxy-3'-fluoro-
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Disease relevance of Fddclurd


High impact information on Fddclurd


Biological context of Fddclurd

  • A phase I study was conducted to evaluate the safety and pharmacokinetics of six escalating single oral doses of 935U83 in 12 HIV-infected adults [4].

Anatomical context of Fddclurd

  • Mild reversible reductions in erythrocytes and associated parameters were seen in mice dosed orally with 2,000 mg of 935U83 per kg per day for 1 and 6 months [2].

Analytical, diagnostic and therapeutic context of Fddclurd

  • 935U83 was rapidly and well absorbed following oral administration with peak plasma concentrations (Cmax) occurring at 0.8 to 1.3 h postdosing [4].


  1. 5-Halogeno-3'-fluoro-2',3'-dideoxyuridines as inhibitors of human immunodeficiency virus (HIV): potent and selective anti-HIV activity of 3'-fluoro-2',3'-dideoxy-5-chlorouridine. Balzarini, J., Van Aerschot, A., Pauwels, R., Baba, M., Schols, D., Herdewijn, P., De Clercq, E. Mol. Pharmacol. (1989) [Pubmed]
  2. 5-Chloro-2',3'-dideoxy-3'-fluorouridine (935U83), a selective anti-human immunodeficiency virus agent with an improved metabolic and toxicological profile. Daluge, S.M., Purifoy, D.J., Savina, P.M., St Clair, M.H., Parry, N.R., Dev, I.K., Novak, P., Ayers, K.M., Reardon, J.E., Roberts, G.B. Antimicrob. Agents Chemother. (1994) [Pubmed]
  3. 3'-Fluoro-2',3'-dideoxy-5-chlorouridine: most selective anti-HIV-1 agent among a series of new 2'- and 3'-fluorinated 2',3'-dideoxynucleoside analogues. Van Aerschot, A., Herdewijn, P., Balzarini, J., Pauwels, R., De Clercq, E. J. Med. Chem. (1989) [Pubmed]
  4. Safety and pharmacokinetics of 5-chloro-2',3'-dideoxy-3'-fluorouridine (935U83) following oral administration of escalating single doses in human immunodeficiency virus-infected adults. Riddler, S.A., Wang, L.H., Bartlett, J.A., Savina, P.M., Packard, M.V., McMahon, D.K., Blum, M.R., Dunn, J.A., Elkins, M.M., Mellors, J.W. Antimicrob. Agents Chemother. (1996) [Pubmed]
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