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Chemical Compound Review:

TENIDAP 5-chloro-2-hydroxy-3- thiophen-2-ylcarbonyl...

Synonyms:

Smith, D.M. et al., Moilanen, E. et al.

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High impact information on TENIDAP

Evaluation of Tenidap (CP-66,248) on human neutrophil arachidonic acid metabolism, chemotactic potential and clinical efficacy in the treatment of rheumatoid arthritis [1].
The inhibitory action of CP-66,248 towards 5-lipoxygenase was comparable with that of timegadine and exceeded that of caffeic acid, and its action against the cyclo-oxygenase pathway was similar to that of other NSAIDs tested [2].

Gene context of TENIDAP

Ten patients with rheumatoid arthritis (RA) were evaluated in a placebo-controlled, double-blind study examining the clinical efficacy of a novel nonsteroidal anti-inflammatory agent: Tenidap (CP-66,248) [1].

References

Evaluation of Tenidap (CP-66,248) on human neutrophil arachidonic acid metabolism, chemotactic potential and clinical efficacy in the treatment of rheumatoid arthritis. Smith, D.M., Johnson, J.A., Loeser, R., Turner, R.A. Agents Actions (1990) [Pubmed]
CP-66,248, a new anti-inflammatory agent, is a potent inhibitor of leukotriene B4 and prostanoid synthesis in human polymorphonuclear leucocytes in vitro. Moilanen, E., Alanko, J., Asmawi, M.Z., Vapaatalo, H. Eicosanoids (1988) [Pubmed]

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