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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Chemical Compound Review: 

Monoxone     sodium 2-chloroethanoate

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Disease relevance of Monochloroethanoic acid

 

High impact information on Monochloroethanoic acid

  • Rats were injected with 80 mg/kg sodium monochloroacetate (SMCA) (single lethal dose) and then infused with saline (control group) or 5% or 10% glucose solution at 2 mL/hour for ten hours [2].
  • Later, they were patch tested to 2 different purity grades of CAPB and 3 possible manufacturing contaminants (dimethylaminopropylamine, amidoamine, and sodium monochloroacetate) [3].
  • Chromatographic separation was achieved within 10 min using a C8 (150x4.6 mm) 5 microm column with a mobile phase containing 20 mM sodium monochloroacetate, pH 2.8 and 12% acetonitrile at a flow-rate of 1.2 ml/min [4].

References

  1. Ninety-day toxicity study of sodium monochloroacetate in Sprague-Dawley rats. Daniel, F.B., Robinson, M., Stober, J.A., Page, N.P., Olson, G.R. Toxicology (1991) [Pubmed]
  2. Therapeutic effects of glucose infusion on monochloroacetic acid exposure in rats. Shimizu, H., Dote, T., Usuda, K., Toshina, Y., Kato, J., Sakai, A., Furuya, E., Kono, K. Toxicology and industrial health. (2002) [Pubmed]
  3. Allergy to cocamidopropyl betaine may be due to amidoamine: a patch test and product use test study. Fowler, J.F., Fowler, L.M., Hunter, J.E. Contact Derm. (1997) [Pubmed]
  4. Liquid chromatography with multi-channel electrochemical detection for the determination of epigallocatechin gallate in rat plasma utilizing an automated blood sampling device. Long, H., Zhu, Y., Cregor, M., Tian, F., Coury, L., Kissinger, C.B., Kissinger, P.T. J. Chromatogr. B Biomed. Sci. Appl. (2001) [Pubmed]
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