High impact information on Dehydrofelodipine

• The dehydrofelodipine/felodipine AUC ratio was lower, diastolic blood pressure lower, and heart rate higher with grapefruit juice than with water [1].
• The oral pharmacokinetics of felodipine and its primary metabolite (dehydrofelodipine) were determined with 250 mL of grapefruit juice, one quarter-strength lime juice, red wine, or water in a randomized crossover study [2].
• Grapefruit juice increased the mean felodipine area under the plasma concentration-time curve (AUC) (mean +/- SE, 55 +/- 9 nmol. h/L versus 29 +/- 6 nmol. h/L; P <.05) and the plasma peak drug concentration (16 +/- 3 nmol/L versus 8 +/- 2 nmol/L, P <.05) and decreased the dehydrofelodipine/felodipine AUC ratio compared with those of water [2].
• Grapefruit juice decreased the dehydrofelodipine/felodipine AUC ratio, but peppermint oil did not [3].
• Plasma concentrations of felodipine and dehydrofelodipine metabolite, blood pressure, and heart rate were measured over 24 hours after single and final steady-state dose [4].

Biological context of Dehydrofelodipine

• The AUC of the M3 metabolite and the M3 metabolite/dehydrofelodipine ratios were reduced [5].
• The pharmacokinetics of felodipine and its dehydrofelodipine metabolite were determined [6].

Associations of Dehydrofelodipine with other chemical compounds

• Erythromycin augmented dehydrofelodipine AUC, Cmax, and t1/2 but decreased dehydrofelodipine/felodipine ratios [5].

Analytical, diagnostic and therapeutic context of Dehydrofelodipine

• Serum felodipine and dehydrofelodipine concentrations were determined by means of gas chromatography/mass spectrometry [7].

References