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Interaction of citrus juices with felodipine and nifedipine.

Six men with borderline hypertension took felodipine 5 mg with water, grapefruit juice, or orange juice. The mean felodipine bioavailability with grapefruit juice was 284 (range 164-469)% of that with water. The dehydrofelodipine/felodipine AUC ratio was lower, diastolic blood pressure lower, and heart rate higher with grapefruit juice than with water. Vasodilatation-related side-effects were more frequent. Orange juice had no such effects. Six healthy men took nifedipine 10 mg with water or grapefruit juice; the bioavailability with grapefruit juice was 134 (108-169)% of that with water.[1]


  1. Interaction of citrus juices with felodipine and nifedipine. Bailey, D.G., Spence, J.D., Munoz, C., Arnold, J.M. Lancet (1991) [Pubmed]
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