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Chemical Compound Review:

AC1O44IT [[[[[(2R,3S,4R,5R)-3,4- dihydroxy-5-(6-oxo...

Synonyms: Diinosine Pentaphosphate

Dunn, P.M. et al., García-Lecea, M. et al., Hoyle, C.H. et al.

Hoyle, Pintor, Gualix, Miras-Portugal, Dunn, Liu, Zhong, King, Burnstock,

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High impact information on Diinosine Pentaphosphate

1. We have compared the antagonist activity of trinitrophenyl-ATP (TNP-ATP) and diinosine pentaphosphate (Ip(5)I) on recombinant P2X receptors expressed in XENOPUS: oocytes with their actions at native P2X receptors in sensory neurones from dorsal root and nodose ganglia [1].
The selective P2X1 antagonist diinosine pentaphosphate failed to inhibit ATP-elicited [Ca2+]i transients, but suramin and PPADS rapidly and reversibly blocked the [Ca2+]i responses to ATP and 2MeSATP [2].
Antagonism of P2X receptors in guinea-pig vas deferens by diinosine pentaphosphate [3].

References

Diinosine pentaphosphate: an antagonist which discriminates between recombinant P2X(3) and P2X(2/3) receptors and between two P2X receptors in rat sensory neurones. Dunn, P.M., Liu, M., Zhong, Y., King, B.F., Burnstock, G. Br. J. Pharmacol. (2000) [Pubmed]
P2X2 characteristics of the ATP receptor coupled to [Ca2+]i increases in cultured Purkinje neurons from neonatal rat cerebellum. García-Lecea, M., Delicado, E.G., Miras-Portugal, M.T., Castro, E. Neuropharmacology (1999) [Pubmed]
Antagonism of P2X receptors in guinea-pig vas deferens by diinosine pentaphosphate. Hoyle, C.H., Pintor, J., Gualix, J., Miras-Portugal, M.T. Eur. J. Pharmacol. (1997) [Pubmed]

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