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MeSH Review

Vas Deferens

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Disease relevance of Vas Deferens


Psychiatry related information on Vas Deferens


High impact information on Vas Deferens

  • In P2X1-receptor-deficient mice, contraction of the vas deferens to sympathetic nerve stimulation is reduced by up to 60% and responses to P2X receptor agonists are abolished [9].
  • Reduced vas deferens contraction and male infertility in mice lacking P2X1 receptors [9].
  • We show here, however, that stimulation of sympathetic nerves innervating the guinea-pig vas deferens releases not only neuronal ATP, but also soluble nucleotidases that break down this ATP to adenosine, indicating that inactivation of ATP is increased by nerve activity [10].
  • Effects of nifedipine on electrical and mechanical responses of rat and guinea pig vas deferens [11].
  • These observations suggest that there are two populations of receptors for noradrenaline on arterioles, and could explain the paradoxical failure of alpha-antagonists to block neuromuscular transmission at some sutonomic end organs such as the vas deferens, arteries and arterioles [12].

Chemical compound and disease context of Vas Deferens


Biological context of Vas Deferens


Anatomical context of Vas Deferens


Associations of Vas Deferens with chemical compounds


Gene context of Vas Deferens


Analytical, diagnostic and therapeutic context of Vas Deferens


  1. Mutations in the cystic fibrosis gene in patients with congenital absence of the vas deferens. Chillón, M., Casals, T., Mercier, B., Bassas, L., Lissens, W., Silber, S., Romey, M.C., Ruiz-Romero, J., Verlingue, C., Claustres, M. N. Engl. J. Med. (1995) [Pubmed]
  2. Birth after preimplantation diagnosis of the cystic fibrosis delta F508 mutation by polymerase chain reaction in human embryos resulting from intracytoplasmic sperm injection with epididymal sperm. Liu, J., Lissens, W., Silber, S.J., Devroey, P., Liebaers, I., Van Steirteghem, A. JAMA (1994) [Pubmed]
  3. Differential distribution of two ATP-gated channels (P2X receptors) determined by immunocytochemistry. Vulchanova, L., Arvidsson, U., Riedl, M., Wang, J., Buell, G., Surprenant, A., North, R.A., Elde, R. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  4. Photolabile opioid derivatives of D-Ala2-Leu5-enkephalin and their interactions with the opiate receptor. Zioudrou, C., Varoucha, D., Loukas, S., Nicolaou, N., Streaty, R.A., Klee, W.A. J. Biol. Chem. (1983) [Pubmed]
  5. Molecular cloning of TA16, a transcriptional repressor that may mediate glucocorticoid-induced growth arrest of leiomyosarcoma cells. Fan, W., Ma, J.X., Cheng, L., Norris, J.S. Mol. Endocrinol. (1997) [Pubmed]
  6. Morphine dependence and diabetes. II. Alterations of normorphine potency in the guinea-pig ileum and mouse vas deferens and of ileal morphine dependence by changes in glucose concentration. Shook, J.E., Kachur, J.F., Brase, D.A., Dewey, W.L. J. Pharmacol. Exp. Ther. (1986) [Pubmed]
  7. Time-response curves for barium and noradrenaline in vas deferens of castrated rat. Jurkiewicz, A., Langeloh, A., Guedes, A.D. Eur. J. Pharmacol. (1977) [Pubmed]
  8. Adenosine 5'-triphosphate (ATP), the neurotransmitter in the prostatic portion of the longitudinal muscle layer of the rat vas deferens. Donoso, M.V., Bates, F., Montiel, J., Huidobro-Toro, J.P. Neurosci. Lett. (1994) [Pubmed]
  9. Reduced vas deferens contraction and male infertility in mice lacking P2X1 receptors. Mulryan, K., Gitterman, D.P., Lewis, C.J., Vial, C., Leckie, B.J., Cobb, A.L., Brown, J.E., Conley, E.C., Buell, G., Pritchard, C.A., Evans, R.J. Nature (2000) [Pubmed]
  10. Neuronal release of soluble nucleotidases and their role in neurotransmitter inactivation. Todorov, L.D., Mihaylova-Todorova, S., Westfall, T.D., Sneddon, P., Kennedy, C., Bjur, R.A., Westfall, D.P. Nature (1997) [Pubmed]
  11. Effects of nifedipine on electrical and mechanical responses of rat and guinea pig vas deferens. Blakeley, A.G., Brown, D.A., Cunnane, T.C., French, A.M., McGrath, J.C., Scott, N.C. Nature (1981) [Pubmed]
  12. Evidence for two populations of excitatory receptors for noradrenaline on arteriolar smooth muscle. Hirst, G.D., Neild, T.O. Nature (1980) [Pubmed]
  13. Testicular CFTR splice variants in patients with congenital absence of the vas deferens. Larriba, S., Bassas, L., Gimenez, J., Ramos, M.D., Segura, A., Nunes, V., Estivill, X., Casals, T. Hum. Mol. Genet. (1998) [Pubmed]
  14. A possible crossed histamine-containing pathway adjacent to the sympathetic system of the rat vas deferens. Campos, H.A. J. Pharmacol. Exp. Ther. (1988) [Pubmed]
  15. Pharmacological differentiation of angiotensin effects in the rabbit isolated vas deferens with dithiothreitol and pertussis toxin. Trachte, G.J. J. Pharmacol. Exp. Ther. (1990) [Pubmed]
  16. Thyroid status and adrenergic receptor subtypes in the rat: comparison of receptor density and responsiveness. Fox, A.W., Juberg, E.N., May, J.M., Johnson, R.D., Abel, P.W., Minneman, K.P. J. Pharmacol. Exp. Ther. (1985) [Pubmed]
  17. Normal vas deferens in fetuses with cystic fibrosis. Gaillard, D.A., Carré-Pigeon, F., Lallemand, A. J. Urol. (1997) [Pubmed]
  18. Effects of cystic fibrosis and congenital bilateral absence of the vas deferens-associated mutations on cystic fibrosis transmembrane conductance regulator-mediated regulation of separate channels. Mickle, J.E., Milewski, M.I., Macek, M., Cutting, G.R. Am. J. Hum. Genet. (2000) [Pubmed]
  19. RTA, a candidate G protein-coupled receptor: cloning, sequencing, and tissue distribution. Ross, P.C., Figler, R.A., Corjay, M.H., Barber, C.M., Adam, N., Harcus, D.R., Lynch, K.R. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  20. Increased plasma catecholamine concentrations and vas deferens norepinephrine biosynthesis in men with elevated blood pressure. DeQuattro, V., Miura, Y., Lurvey, A., Cosgrove, M., Mendez, R. Circ. Res. (1975) [Pubmed]
  21. Solubilization and molecular size determination of the P2x purinoceptor from rat vas deferens. Bo, X., Simon, J., Burnstock, G., Barnard, E.A. J. Biol. Chem. (1992) [Pubmed]
  22. Cloning, sequencing, and enzymatic activity of an inducible aldo-keto reductase from Chinese hamster ovary cells. Hyndman, D.J., Takenoshita, R., Vera, N.L., Pang, S.C., Flynn, T.G. J. Biol. Chem. (1997) [Pubmed]
  23. Characterization of the androgen receptor from a Syrian hamster ductus deferens tumor cell line (DDT1). Norris, J.S., Kohler, P.O. Science (1976) [Pubmed]
  24. Vipergic nerves in the penis. Polak, J.M., Gu, J., Mina, S., Bloom, S.R. Lancet (1981) [Pubmed]
  25. Plasminogen activator and mouse spermatozoa: urokinase synthesis in the male genital tract and binding of the enzyme to the sperm cell surface. Huarte, J., Belin, D., Bosco, D., Sappino, A.P., Vassalli, J.D. J. Cell Biol. (1987) [Pubmed]
  26. Sodium nitroprusside and other smooth muscle-relaxants increase cyclic GMP levels in rat ductus deferens. Schultz, K., Schultz, K., Schultz, G. Nature (1977) [Pubmed]
  27. Increases in cyclic GMP levels may not mediate relaxant effects of sodium nitroprusside, verapamil and hydralazine in rat vas deferens. Diamond, J., Janis, R.A. Nature (1978) [Pubmed]
  28. Purinergic receptors: photoaffinity analog of adenosine triphosphate is a specific adenosine triphosphate antagonist. Hogaboom, G.K., O'Donnell, J.P., Fedan, J.S. Science (1980) [Pubmed]
  29. Anandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor-mediated signal transduction. Felder, C.C., Briley, E.M., Axelrod, J., Simpson, J.T., Mackie, K., Devane, W.A. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  30. Dynorphin-(1-13), an extraordinarily potent opioid peptide. Goldstein, A., Tachibana, S., Lowney, L.I., Hunkapiller, M., Hood, L. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
  31. Is congenital bilateral absence of vas deferens a primary form of cystic fibrosis? Analyses of the CFTR gene in 67 patients. Mercier, B., Verlingue, C., Lissens, W., Silber, S.J., Novelli, G., Bonduelle, M., Audrézet, M.P., Férec, C. Am. J. Hum. Genet. (1995) [Pubmed]
  32. Identification and characterization of a novel human aldose reductase-like gene. Cao, D., Fan, S.T., Chung, S.S. J. Biol. Chem. (1998) [Pubmed]
  33. Characteristic multiorgan pathology of cystic fibrosis in a long-living cystic fibrosis transmembrane regulator knockout murine model. Durie, P.R., Kent, G., Phillips, M.J., Ackerley, C.A. Am. J. Pathol. (2004) [Pubmed]
  34. Abnormal regulation of the sympathetic nervous system in alpha2A-adrenergic receptor knockout mice. Altman, J.D., Trendelenburg, A.U., MacMillan, L., Bernstein, D., Limbird, L., Starke, K., Kobilka, B.K., Hein, L. Mol. Pharmacol. (1999) [Pubmed]
  35. Tissue-specific expression of two aldose reductase-like genes in mice: abundant expression of mouse vas deferens protein and fibroblast growth factor-regulated protein in the adrenal gland. Lau, E.T., Cao, D., Lin, C., Chung, S.K., Chung, S.S. Biochem. J. (1995) [Pubmed]
  36. Activity of the delta-opioid receptor is partially reduced, whereas activity of the kappa-receptor is maintained in mice lacking the mu-receptor. Matthes, H.W., Smadja, C., Valverde, O., Vonesch, J.L., Foutz, A.S., Boudinot, E., Denavit-Saubié, M., Severini, C., Negri, L., Roques, B.P., Maldonado, R., Kieffer, B.L. J. Neurosci. (1998) [Pubmed]
  37. Cloning, expression, and tissue distribution of the rat homolog of the bovine alpha 1C-adrenergic receptor provide evidence for its classification as the alpha 1A subtype. Perez, D.M., Piascik, M.T., Malik, N., Gaivin, R., Graham, R.M. Mol. Pharmacol. (1994) [Pubmed]
  38. The effect of depletion of the noradrenaline content on the response of the mouse vas deferens to electrical stimulation and to tyramine [proceedings]. Marshall, I., Nasmyth, P.A., Shepperson, N.B. J. Physiol. (Lond.) (1977) [Pubmed]
  39. Tetanus toxin-mediated cleavage of cellubrevin inhibits proton secretion in the male reproductive tract. Breton, S., Nsumu, N.N., Galli, T., Sabolic, I., Smith, P.J., Brown, D. Am. J. Physiol. Renal Physiol. (2000) [Pubmed]
  40. Testicular control of prostaglandin E2 production in rat vas deferens. Saito, H., Noguchi, K., Winters, S.J., Keeping, H.S., Oshima, H., Troen, P. Endocrinology (1986) [Pubmed]
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