Disease relevance of p-Hydroxyphenylpyruvic acid

• This toxicity does not appear to involve either tyramine or p-hydroxyphenylpyruvic acid formation [1].
• The Escherichia coli bifunctional T-protein transforms chorismic acid to p-hydroxyphenylpyruvic acid in the l-tyrosine biosynthetic pathway [2].

High impact information on p-Hydroxyphenylpyruvic acid

• The Sulphation of p-hydroxyphenylpyruvic acid and related compounds by the rat liver cytosol [3].
• DNA damage and repair in mammalian cells exposed to p-hydroxyphenylpyruvic acid [4].

Associations of p-Hydroxyphenylpyruvic acid with other chemical compounds

• Cytosol preparations of rat liver and kidney were examined for their ability to transfer sulphate from adenosine 3'-phosphate 5'-sulphatophosphate to p-hydroxyphenylpyruvic acid [3].

Analytical, diagnostic and therapeutic context of p-Hydroxyphenylpyruvic acid

• Chemical oxidation of p-hydroxyphenylpyruvic acid in aqueous solution by capillary electrophoresis with an electrochemiluminescence detection system [5].
• As nonprotein [14C]metabolites, in plasma, tumor and brain tissues, p-hydroxyphenylpyruvic acid, p-hydroxyphenyllactic acid, and unidentified metabolites were observed by high performance liquid chromatography [6].
• The isolated protein was identified as MIF by SDS-electrophoresis, immunoblotting, sequencing of the N-terminal amino acid residues, and also by determination of keto-enol tautomerase activity that is characteristic of MIF with p-hydroxyphenylpyruvic acid as a substrate [7].

References