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Chemical Compound Review

AC1LCVII     (2S,3R,4R,5R)-2-(6- aminopurin-9-yl)-5...

Synonyms: SureCN10814487, ZINC03978048, 524-69-6, 9-pentofuranosyl-9H-purin-6-amine, 9H-purin-6-amine, 9-pentofuranosyl-
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Disease relevance of adenosine

  • A Salmonella miaA mutant lacking the isopentenylation enzyme contains an A37 rather than any of the modified forms [1].
  • Since adenosine (Ado) induced muscarinic potassium current (IK(Ado)) and ATP sensitive potassium current (IK(ATP)) are discussed to be activated during ischemia we studied the effect of propranolol on IK(Ado) and IK(ATP) [2].

High impact information on adenosine

  • Perfusion with PGI(2), NTG, and Ado concentration-dependently increased coronary flow (CF) [3].
  • A discrepancy between the elevation of CBF and of the tissue concentration of Ade does not support a direct role of Ade in the asphyctic cerebral vasodilation in the fetus [4].


  1. A modified nucleotide in tRNA as a possible regulator of aerobiosis: synthesis of cis-2-methyl-thioribosylzeatin in the tRNA of Salmonella. Buck, M., Ames, B.N. Cell (1984) [Pubmed]
  2. Propranolol inhibits IK(Ado) by competitive A1-receptor interaction. Brandts, B., Dirkmann, D., Borchard, R., Wickenbrock, I., Van Bracht, M., Prull, M.W., Trappe, H.J. Zeitschrift für Kardiologie. (2004) [Pubmed]
  3. Prostacyclin improves transcoronary myocardial delivery of adipose tissue-derived stromal cells. Madonna, R., Rinaldi, L., Rossi, C., Geng, Y.J., De Caterina, R. Eur. Heart J. (2006) [Pubmed]
  4. Extracellular increase of hypoxanthine and xanthine in the cortex and basal ganglia of fetal lambs during hypoxia-ischemia. Kjellmer, I., Andiné, P., Hagberg, H., Thiringer, K. Brain Res. (1989) [Pubmed]
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