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Gene Review:

miaA - tRNA dimethylallyltransferase

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

Hagervall, T.G. et al., Buck, M. et al.

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Disease relevance of miaA

A Salmonella miaA mutant lacking the isopentenylation enzyme contains an A37 rather than any of the modified forms [1].

High impact information on miaA

We have used the mutants hisT, miaA and miaB and trmD, which are deficient in the biosynthesis of psi, ms2io6A, and m1G, respectively, to study the functional aspects of the respective modified nucleosides [2].

References

A modified nucleotide in tRNA as a possible regulator of aerobiosis: synthesis of cis-2-methyl-thioribosylzeatin in the tRNA of Salmonella. Buck, M., Ames, B.N. Cell (1984) [Pubmed]
Role of tRNA modification in translational fidelity. Hagervall, T.G., Ericson, J.U., Esberg, K.B., Li, J.N., Björk, G.R. Biochim. Biophys. Acta (1990) [Pubmed]

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