The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

AC1O532G     (2S)-2-[[(2R,3R)-2-amino-3- hydroxy...

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Thr-Leu

  • A highly active competitor peptide analog was synthesized in which Tyr was separated from the Thr-Leu pair by a pentaproline spacer [1].
  • This set of tPA-specific PAI-1 mutants contained a wide range of amino acid substitutions at P1 including Asn, Gln, His, Ser, Thr, Leu, Met, and all the aromatic amino acids [2].
  • In sperm whale myoglobin, His64(E7) was replaced with Gln, Gly, Ala, Val, Thr, Leu, and Phe; Val68(E11) was replaced with Ala, Ile, Leu, and Phe; Leu29(B10) was replaced with Ala, Val, and Phe [3].
  • His 253 in the N-terminal half-molecule of human lactoferrin, LfN (residues 1-333), has been changed to Gly, Ala, Pro, Thr, Leu, Phe, Met, Tyr, Glu, Gln, and Cys by oligonucleotide-directed mutagenesis [4].
  • All other substitutions (Val, Thr, Leu, Ala, and Asp) reduced affinity by at least 90-fold and caused distinct shifts in fine specificity [5].

Gene context of Thr-Leu

  • The prediction of a transmembrane domain between residues 37 and 54 of seabream TNF alpha and the presence of a conserved Thr-Leu sequence, which is associated with cleavage of the mouse TNF alpha molecule, suggest that seabream TNF alpha exists in two forms, a membrane-bound and a soluble form [6].
  • The two highly expressed genes of AcNPV, polh and the p10, differ from the overall AcNPV codon usage profile with respect to at least nine amino acids (Val, Ala, Ser, Lys, Ile, Thr, Leu, Phe, Arg) [7].


  1. Competitor analogs for defined T cell antigens: peptides incorporating a putative binding motif and polyproline or polyglycine spacers. Maryanski, J.L., Verdini, A.S., Weber, P.C., Salemme, F.R., Corradin, G. Cell (1990) [Pubmed]
  2. Identification of tissue-type plasminogen activator-specific plasminogen activator inhibitor-1 mutants. Evidence that second sites of interaction contribute to target specificity. Sherman, P.M., Lawrence, D.A., Verhamme, I.M., Paielli, D., Shore, J.D., Ginsburg, D. J. Biol. Chem. (1995) [Pubmed]
  3. The mechanism of autooxidation of myoglobin. Brantley, R.E., Smerdon, S.J., Wilkinson, A.J., Singleton, E.W., Olson, J.S. J. Biol. Chem. (1993) [Pubmed]
  4. Mutagenesis of the histidine ligand in human lactoferrin: iron binding properties and crystal structure of the histidine-253-->methionine mutant. Nicholson, H., Anderson, B.F., Bland, T., Shewry, S.C., Tweedie, J.W., Baker, E.N. Biochemistry (1997) [Pubmed]
  5. Contribution of a single heavy chain residue to specificity of an anti-digoxin monoclonal antibody. Schildbach, J.F., Shaw, S.Y., Bruccoleri, R.E., Haber, E., Herzenberg, L.A., Jager, G.C., Jeffrey, P.D., Panka, D.J., Parks, D.R., Near, R.I. Protein Sci. (1994) [Pubmed]
  6. Molecular cloning and expression analysis of tumor necrosis factor alpha from a marine fish reveal its constitutive expression and ubiquitous nature. García-Castillo, J., Pelegrín, P., Mulero, V., Meseguer, J. Immunogenetics (2002) [Pubmed]
  7. Codon usage in the prototype baculovirus--Autographa californica nuclear polyhedrosis virus. Ranjan, A., Hasnain, S.E. Indian J. Biochem. Biophys. (1995) [Pubmed]
WikiGenes - Universities