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Chemical Compound Review

Methylene, diphenyl-     phenylmethylbenzene

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Disease relevance of phenylmethylbenzene

  • RESULTS: Onset of attacks of dyspnea with wheeze, attacks of dyspnea or cough at rest, and chest tightness were significantly associated with MDI exposure after controlling for age, smoking, and wood dust exposure [1].

High impact information on phenylmethylbenzene

  • Chronic pulmonary effects of respirable methylene diphenyl diisocyanate (MDI) aerosol in rats: combination of findings from two bioassays [2].
  • By simulation at a worksite, the average exposure to polymerized MDI was estimated to be 5.5-300 microg/m3 during injection work and 18-4300 microg/m3 during short-term exposure, the highest exposure occurring when cured polyurethane was ground [3].

Analytical, diagnostic and therapeutic context of phenylmethylbenzene

  • Methylene diphenyl diisocyanate (MDI) and MDI prepolymer exposure was estimated by filter sampling, and the filters were analyzed by high-performance liquid chromatography [3].


  1. Symptom onset in the first 2 years of employment at a wood products plant using diisocyanates: some observations relevant to occupational medical screening. Wang, M.L., Petsonk, E.L. Am. J. Ind. Med. (2004) [Pubmed]
  2. Chronic pulmonary effects of respirable methylene diphenyl diisocyanate (MDI) aerosol in rats: combination of findings from two bioassays. Feron, V.J., Kittel, B., Kuper, C.F., Ernst, H., Rittinghausen, S., Muhle, H., Koch, W., Gamer, A., Mallett, A.K., Hoffmann, H.D. Arch. Toxicol. (2001) [Pubmed]
  3. Asthma in tunnel workers exposed to synthetic resins. Ulvestad, B., Melbostad, E., Fuglerud, P. Scandinavian journal of work, environment & health. (1999) [Pubmed]
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