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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Dyspnea


Psychiatry related information on Dyspnea


High impact information on Dyspnea

  • The perception of dyspnea was scored on the Borg scale during breathing through inspiratory resistances ranging from 0 to 30.9 cm of water per liter per second [11].
  • During the first week after discharge, patients receiving prednisone reported significantly lower mean (+/- SD) daily symptom scores for shortness of breath (1.4 +/- 0.4 vs. 2.5 +/- 0.4, P less than 0.01) and less frequent use of an inhaled bronchodilator (5.2 +/- 0.5 vs. 6.9 +/- 0.2 puffs per day, P less than 0.05) than patients receiving placebo [12].
  • Niacin-treated rats showed delayed and reduced dyspnea [13].
  • On the summit AMS was less common in climbers receiving acetazolamide, and they experienced less headache, nausea, drowsiness, shortness of breath, and dizziness and a greater sense of satisfaction and psychological well-being [14].
  • However, there were no significant differences between the placebo and aminophylline groups in any of the spirometric measurements or the dyspnea indices (p greater than 0.5 in all five analyses) [15].

Chemical compound and disease context of Dyspnea

  • Borg Dyspnea Scores and Dyspnea-Fatigue Ratings improved in the epoprostenol group [16].
  • Significant improvements in FEV1 and FVC measured before and after metaproterenol treatment and in dyspnea occurred over time in both treatment groups (p less than 0.05 for all measurements) [15].
  • In selected patients, chronic afterload reduction with oral hydralazine may result in increased cardiac reserve, decreased pulmonary congestion or decreased myocardial oxygen demands, thereby improving or abolishing resting or exertional dyspnea or angina [17].
  • Symptoms were common, regardless of estrogen treatment (abdominal pain 60%, shortness of breath 40%, or both 35%) [18].
  • Of 19 consecutive smokers of cocaine, "freebase" cocaine users, admitted to a chemical dependence program, 12 (63%) had respiratory symptoms and ten (58%) noted dyspnea [19].

Biological context of Dyspnea


Anatomical context of Dyspnea

  • A 72-year-old woman was initially seen with increasing dyspnea and a new murmur occurring six years after mitral valve replacement with a glutaraldehyde-stabilized porcine xenograft [25].
  • We conclude that epinephrine appears to be an important factor in the regulation of the bronchial smooth muscle tone in patients with early morning dyspnea [26].
  • The role of endogenous hydrocortisone in the regulation of lymphocyte activity was assayed in patients with asthma (patients with chronic nonspecific lung disease, characterized by attacks of dyspnea, alternating with symptom-free periods) and healthy control subjects [27].
  • In patients with hypertrophic cardiomyopathy, clinical symptoms such as exertional dyspnea, angina and collapse are considered to be rather the consequence of diastolic than of systolic dysfunction of the left ventricle [28].
  • Exacerbations of COPD, which include combinations of dyspnea, cough, wheezing, increased sputum production (and a change in its color to green or yellow), are common [29].

Gene context of Dyspnea


Analytical, diagnostic and therapeutic context of Dyspnea


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  8. The goitrogenic effect of 4,4'-oxydianiline in rats and mice. Hayden, D.W., Wade, G.G., Handler, A.H. Vet. Pathol. (1978) [Pubmed]
  9. Stroke and pulmonary thromboembolism after a long flight. Belvís, R., Masjuan, J., García-Barragán, N., Cocho, D., Martí-Fàbregas, J., Santamaría, A., Leta, R.G., Martínez-Castrillo, J.C., Fernández-Ruiz, L.C., Gilo, F., Martí-Vilalta, J.L. Eur. J. Neurol. (2005) [Pubmed]
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  11. Chemosensitivity and perception of dyspnea in patients with a history of near-fatal asthma. Kikuchi, Y., Okabe, S., Tamura, G., Hida, W., Homma, M., Shirato, K., Takishima, T. N. Engl. J. Med. (1994) [Pubmed]
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  13. Niacin Reduces Paraquat Toxicity in Rats. Brown, O.R., Heitkamp, M., Song, C.S. Science (1981) [Pubmed]
  14. Acute mountain sickness and acetazolamide. Clinical efficacy and effect on ventilation. Larson, E.B., Roach, R.C., Schoene, R.B., Hornbein, T.F. JAMA (1982) [Pubmed]
  15. Aminophylline for acute exacerbations of chronic obstructive pulmonary disease. A controlled trial. Rice, K.L., Leatherman, J.W., Duane, P.G., Snyder, L.S., Harmon, K.R., Abel, J., Niewoehner, D.E. Ann. Intern. Med. (1987) [Pubmed]
  16. Continuous intravenous epoprostenol for pulmonary hypertension due to the scleroderma spectrum of disease. A randomized, controlled trial. Badesch, D.B., Tapson, V.F., McGoon, M.D., Brundage, B.H., Rubin, L.J., Wigley, F.M., Rich, S., Barst, R.J., Barrett, P.S., Kral, K.M., Jöbsis, M.M., Loyd, J.E., Murali, S., Frost, A., Girgis, R., Bourge, R.C., Ralph, D.D., Elliott, C.G., Hill, N.S., Langleben, D., Schilz, R.J., McLaughlin, V.V., Robbins, I.M., Groves, B.M., Shapiro, S., Medsger, T.A. Ann. Intern. Med. (2000) [Pubmed]
  17. Rest and exercise hemodynamic effects of oral hydralazine in patients with coronary artery disease and left ventricular dysfunction. Hindman, M.C., Slosky, D.A., Peter, R.H., Newman, G.E., Jones, R.H., Wallace, A.G. Circulation (1980) [Pubmed]
  18. Postmenopausal estrogen therapy selectively stimulates hepatic enlargement in women with autosomal dominant polycystic kidney disease. Sherstha, R., McKinley, C., Russ, P., Scherzinger, A., Bronner, T., Showalter, R., Everson, G.T. Hepatology (1997) [Pubmed]
  19. Pulmonary dysfunction in 'freebase' cocaine users. Itkonen, J., Schnoll, S., Glassroth, J. Arch. Intern. Med. (1984) [Pubmed]
  20. Growth of hepatocellular carcinoma into the right atrium. Report of five cases. Kato, Y., Tanaka, N., Kobayashi, K., Ikeda, T., Hattori, N., Nonomura, A. Ann. Intern. Med. (1983) [Pubmed]
  21. Phase I trial of murine monoclonal antibody L6 in combination with subcutaneous interleukin-2 in patients with advanced carcinoma of the breast, colorectum, and lung. Ziegler, L.D., Palazzolo, P., Cunningham, J., Janus, M., Itoh, K., Hayakawa, K., Hellstrom, I., Hellstrom, K.E., Nicaise, C., Dennin, R. J. Clin. Oncol. (1992) [Pubmed]
  22. Lung function improvements with once-daily tiotropium in chronic obstructive pulmonary disease. Casaburi, R., Conoscenti, C.S. Am. J. Med. (2004) [Pubmed]
  23. The effect of acetazolamide on ventilation in panic disorder patients. Gorman, J.M., Papp, L.A., Coplan, J., Martinez, J., Liebowitz, M.R., Klein, D.F. The American journal of psychiatry. (1993) [Pubmed]
  24. Pulmonary hemorrhage after intracoronary stent placement. Brown, D.L., MacIsaac, A.I., Topol, E.J. J. Am. Coll. Cardiol. (1994) [Pubmed]
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  27. Sensitivity to hydrocortisone is a relevant factor in the immunoendocrine relationship. I. The cell-mediated immune response in relation to blood levels and in vitro immunosuppressive effects of hydrocortisone in patients with asthma and healthy control subjects. Weller, F.R., Weller, H.H., Kallenberg, C.G., The, T.H., Orie, N.G. J. Allergy Clin. Immunol. (1986) [Pubmed]
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  29. Do bacteria cause exacerbations of COPD? Hirschmann, J.V. Chest (2000) [Pubmed]
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  31. Response of C-reactive protein and serum amyloid A to influenza A infection in older adults. Falsey, A.R., Walsh, E.E., Francis, C.W., Looney, R.J., Kolassa, J.E., Hall, W.J., Abraham, G.N. J. Infect. Dis. (2001) [Pubmed]
  32. Efficacy and safety of a monoclonal antibody recognizing interleukin-8 in COPD: a pilot study. Mahler, D.A., Huang, S., Tabrizi, M., Bell, G.M. Chest (2004) [Pubmed]
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  35. Stress-induced left ventricular outflow tract obstruction: a potential cause of dyspnea in the elderly. Henein, M.Y., O'Sullivan, C., Sutton, G.C., Gibson, D.G., Coats, A.J. J. Am. Coll. Cardiol. (1997) [Pubmed]
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