Disease relevance of Lung

• Systemic and pulmonary effects of nitroprusside during mitral valve replacement in patients with mitral regurgitation [1].
• However, the existence of multiple pulmonary effects of O2 toxicity and the complexity of their interactions require awareness that deviations from the average relationships may occur in different individuals or under varying conditions of O2 exposure and subsequent recovery [2].
• Cardiovascular and pulmonary effects following the administration of 0.3 mg/kg of etomidate were studied in patients with documented cardiac disease [3].
• The pulmonary effects of hyperventilation following infusion of sodium salicylate into the cisterna magna was studied in 16 spontaneously breathing adult sheep [4].
• Our purpose was to evaluate the pulmonary effects of mannitol infusion in a rat model of acute lung injury induced by oleic acid (OA) to compare the effects of mannitol to those of another diuretic, furosemide (FUR), and to assess if mannitol effects remained after correction of the volume depletion induced by this agent [5].

High impact information on Lung

• Here we show that mice lacking signal transducer and activator of transcription 6 (STAT6) were protected from all pulmonary effects of IL-13 [6].
• Cardiac and pulmonary effects of acebutolol [7].
• Amiodarone and pulmonary effects [8].
• Pulmonary effects of carmustine (bischloroethylnitrosourea, BCNU) [9].
• Letter: Placidyl and pulmonary effects [10].

Chemical compound and disease context of Lung

• Analysis of toxicity revealed no decrease in cardiac function by ultrasound examination and no pulmonary effects noted by carbon monoxide diffusion [11].
• A double blind trial was set up to study the pulmonary effects of specific treatment with oxamniquine of 40 patients with chronic schistosomiasis mansoni [12].
• Among the eight amines tested for both upper airway irritation and pulmonary toxicity, diisopropylamine and di-n-butylamine showed a RD50TC/RD50 ratio of less than 1, indicating that the respiratory toxicity induced by these two amines would be related primarily to pulmonary effects [13].
• Therefore, to examine the extent to which a given control limit may be valid for nontoxic dusts with different physical characteristics, this study compared the pulmonary effects in rats of inhalation exposure to two poorly soluble dusts of similar density and with relatively low toxicity: titanium dioxide and barium sulfate [14].
• Moreover, it had to be established to what extent the bronchial responsiveness to inhaled salbutamol was retained and whether pulmonary effects were related to the severity of bronchial hyperreactivity [15].

Biological context of Lung

• The contributions of several recent reports to the definition of pulmonary effects of PVC dust inhalation are reviewed [16].
• We conclude that tolazoline effects pulmonary vasodilatation by a histaminergic mechanism and that subsequent refractoriness to the drug is a calcium-dependent process which may be partially mediated by an alpha-adrenergic mechanism [17].
• We conclude that TO by microcautery, even of short duration, has diverse pulmonary effects including stimulating increased levels of cyclin D1 with probable cell cycle progression, type I cell differentiation, and possibly inhibiting type II cell function [18].
• The data tend to indicate early pulmonary effects of air pollution in children living adjacent to industry and exposed to elevated levels of SO2 and NO2 [19].
• Cardiovascular and pulmonary effects of betamethasone during midtrimester on fetal rats [20].

Anatomical context of Lung

• Thromboxane A2 (TXA2) and prostaglandin H2 (PGH2) are potent constrictors of airway smooth muscle and may mediate some of the pulmonary effects of leukotrienes [21].
• To investigate the pulmonary effects of steroid treatment in neonates with meconium aspiration, 25 10- to 12-d-old piglets were studied for 6 h after an intratracheal bolus of human meconium [22].
• In this prospective, randomized, double-blind, placebo-controlled study, we examined the pulmonary effects of methylprednisolone in patients undergoing coronary artery bypass grafting (CABG) and early tracheal extubation [23].
• Since Ca2+ is necessary for contraction of airway and vascular smooth muscle as well as for activation of phospholipase A2 and 5-lipoxygenase enzymes, we wondered whether the calcium antagonist verapamil would modify the endotoxin-mediated pulmonary effects as well as the generation of circulating eicosanoids [24].

Associations of Lung with chemical compounds

• Cardiovascular and pulmonary effects of thromboxane B2 in the dog [25].
• All of the pulmonary effects of BHT are abolished if the mice are pretreated with cedrene, an inducer of drug-detoxifying enzymes [26].
• Of the pulmonary function tests used, the DLCO was shown to be the most sensitive indicator of subclinical bleomycin pulmonary effects [27].
• Pulmonary effects of topical timolol [28].
• Salbutamol inhibits pulmonary effects of platelet activating factor in man [29].

Gene context of Lung

• Endothelin: systemic arterial and pulmonary effects of a new peptide with potent biologic properties [30].
• Increased expression of a transcription factor EGR1 with tumorigenic and other biological activities could contribute to the deleterious pulmonary effects of exposure to these environmental agents [31].
• It is likely that in CF local pulmonary effects of cytokines are of more pathophysiologic significance than systemic effects [32].
• Due to the complex pulmonary effects of CGRP with bronchoconstriction and vasodilatation and diverse immunomodulatory actions, potential anti-asthma drugs based on this peptide have not been established so far [33].
• In this article, I have classified the drugs known to produce adverse pulmonary effects as follows: chemotherapeutic, cardiovascular, antibiotic, and anti-inflammatory agents, drugs known to induce systemic lupus erythematosus, inhalants, illicit drugs such as heroin, and miscellaneous drugs [34].

Analytical, diagnostic and therapeutic context of Lung

• Systemic and pulmonary effects of fluticasone administered through a metered-dose inhaler in rats [35].
• The pulmonary effects of the BFO combination were assessed during the course of the therapy by bronchoalveolar lavage (BAL) analysis and pulmonary hydroxyproline (OH-Pro) content [36].
• A comparison of plethysmography, spirometry and oscillometry for assessing the pulmonary effects of inhaled ipratropium bromide in healthy subjects and patients with asthma [37].
• Neoplastic pulmonary effects of lower doses of vinyl chloride (0 = control, 1, 10, 100, 300, and 600 ppm) and short-term exposure (4 weeks) by inhalation have been studied by light and electron microscopy in 220 mice [38].
• In two, randomized, placebo-controlled, 5-way crossover trials, the pulmonary effects of celiprolol 200 and 400 mg, propranolol 40 mg and atenolol 100 mg were compared in 34 asthmatic patients [39].

References