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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Lung


High impact information on Lung


Chemical compound and disease context of Lung


Biological context of Lung


Anatomical context of Lung


Associations of Lung with chemical compounds


Gene context of Lung

  • Endothelin: systemic arterial and pulmonary effects of a new peptide with potent biologic properties [30].
  • Increased expression of a transcription factor EGR1 with tumorigenic and other biological activities could contribute to the deleterious pulmonary effects of exposure to these environmental agents [31].
  • It is likely that in CF local pulmonary effects of cytokines are of more pathophysiologic significance than systemic effects [32].
  • Due to the complex pulmonary effects of CGRP with bronchoconstriction and vasodilatation and diverse immunomodulatory actions, potential anti-asthma drugs based on this peptide have not been established so far [33].
  • In this article, I have classified the drugs known to produce adverse pulmonary effects as follows: chemotherapeutic, cardiovascular, antibiotic, and anti-inflammatory agents, drugs known to induce systemic lupus erythematosus, inhalants, illicit drugs such as heroin, and miscellaneous drugs [34].

Analytical, diagnostic and therapeutic context of Lung


  1. Systemic and pulmonary effects of nitroprusside during mitral valve replacement in patients with mitral regurgitation. Lappas, D.G., Ohtaka, M., Fahmy, N.R., Buckley, M.J. Circulation (1978) [Pubmed]
  2. Effects of prolonged oxygen exposure at 1.5, 2.0, or 2.5 ATA on pulmonary function in men (predictive studies V). Clark, J.M., Lambertsen, C.J., Gelfand, R., Flores, N.D., Pisarello, J.B., Rossman, M.D., Elias, J.A. J. Appl. Physiol. (1999) [Pubmed]
  3. Cardiovascular and pulmonary responses following etomidate induction of anesthesia in patients with demonstrated cardiac disease. Gooding, J.M., Weng, J.T., Smith, R.A., Berninger, G.T., Kirby, R.R. Anesth. Analg. (1979) [Pubmed]
  4. Acute respiratory failure following pharmacologically induced hyperventilation: an experimental animal study. Mascheroni, D., Kolobow, T., Fumagalli, R., Moretti, M.P., Chen, V., Buckhold, D. Intensive care medicine. (1988) [Pubmed]
  5. Effects of mannitol on the acute lung injury induced by oleic acid in rats. Hilkner-Silva, M., Leme, A.S., Arantes-Costa, F.M., Saldiva, P.H., Lichtenstein, A., Martins, M.A. Shock (2001) [Pubmed]
  6. Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma. Kuperman, D.A., Huang, X., Koth, L.L., Chang, G.H., Dolganov, G.M., Zhu, Z., Elias, J.A., Sheppard, D., Erle, D.J. Nat. Med. (2002) [Pubmed]
  7. Cardiac and pulmonary effects of acebutolol. Kumana, C.R., Kaye, C.M., Leighton, M., Turner, P., Hamer, J. Lancet (1975) [Pubmed]
  8. Amiodarone and pulmonary effects. Dake, M.D., Golden, J.A. Ann. Intern. Med. (1983) [Pubmed]
  9. Pulmonary effects of carmustine (bischloroethylnitrosourea, BCNU). Kaplan, R.L. Ann. Intern. Med. (1979) [Pubmed]
  10. Letter: Placidyl and pulmonary effects. Rosenthal, R., Brown, J.M. Ann. Intern. Med. (1976) [Pubmed]
  11. Treatment of Hodgkin's disease in children with alternating mechlorethamine, vincristine, procarbazine, and prednisone (MOPP) and adriamycin, bleomycin, vinblastine, and dacarbazine (ABVD) courses without radiotherapy. van den Berg, H., Stuve, W., Behrendt, H. Med. Pediatr. Oncol. (1997) [Pubmed]
  12. Pulmonary schistosomiasis mansoni: post-treatment pulmonary clinical-radiological alterations in patients in the chronic phase: a double-blind study. Pedroso, E.R., Lambertucci, J.R., Greco, D.B., Rocha, O.d.e. .C., Ferreira, C.S., Raso, P. Trans. R. Soc. Trop. Med. Hyg. (1987) [Pubmed]
  13. Nasal irritation and pulmonary toxicity of aliphatic amines in mice. Gagnaire, F., Azim, S., Bonnet, P., Simon, P., Guenier, J.P., de Ceaurriz, J. Journal of applied toxicology : JAT. (1989) [Pubmed]
  14. Inhalation of poorly soluble particles. I. Differences in inflammatory response and clearance during exposure. Cullen, R.T., Tran, C.L., Buchanan, D., Davis, J.M., Searl, A., Jones, A.D., Donaldson, K. Inhalation toxicology. (2000) [Pubmed]
  15. Effect of zatebradine, a novel 'sinus node inhibitor', on pulmonary function compared to placebo. Maesen, F.P., Smeets, J.J., van Noord, J.A., Nehmiz, G., Wald, F.D., Cornelissen, P.J. Pulmonary pharmacology. (1994) [Pubmed]
  16. Review of pulmonary effects of poly(vinyl chloride) and vinyl chloride exposure. Lilis, R. Environ. Health Perspect. (1981) [Pubmed]
  17. Adaptation of fetal pulmonary blood flow to local infusion of tolazoline. Abman, S.H., Wilkening, R.B., Ward, R.M., Accurso, F.J. Pediatr. Res. (1986) [Pubmed]
  18. Tracheal occlusion stimulates cell cycle progression and type I cell differentiation in lungs of fetal rats. Yoshizawa, J., Chapin, C.J., Sbragia, L., Ertsey, R., Gutierrez, J.A., Albanese, C.T., Kitterman, J.A. Am. J. Physiol. Lung Cell Mol. Physiol. (2003) [Pubmed]
  19. The University of Akron study on air pollution and human health effects I. Methodology, baseline data, and aerometrics. Mostardi, R.A., Ely, D.L., Woebkenberg, N.R., Richardson, B., Jarrett, M.T. Arch. Environ. Health (1981) [Pubmed]
  20. Cardiovascular and pulmonary effects of betamethasone during midtrimester on fetal rats. Wu, F.F., Momma, K., Takao, A. Fetal. Diagn. Ther. (1993) [Pubmed]
  21. Characterization of a thromboxane A2/prostaglandin H2 receptor in guinea pig lung membranes using a radioiodinated thromboxane mimetic. Saussy, D.L., Mais, D.E., Dubé, G.P., Magee, D.E., Brune, K.A., Kurtz, W.L., Williams, C.M. Mol. Pharmacol. (1991) [Pubmed]
  22. Dexamethasone treatment attenuates pulmonary injury in piglet meconium aspiration. Holopainen, R., Laine, J., Halkola, L., Aho, H., Kääpä, P. Pediatr. Res. (2001) [Pubmed]
  23. Pulmonary effects of methylprednisolone in patients undergoing coronary artery bypass grafting and early tracheal extubation. Chaney, M.A., Nikolov, M.P., Blakeman, B., Bakhos, M., Slogoff, S. Anesth. Analg. (1998) [Pubmed]
  24. Effect of verapamil on pulmonary and eicosanoid responses to endotoxin in awake sheep. Ahmed, T., D'Brot, J., Wasserman, M., Muccitelli, R., Robinson, M., Tucker, S., Marchette, B. J. Appl. Physiol. (1988) [Pubmed]
  25. Cardiovascular and pulmonary effects of thromboxane B2 in the dog. Friedman, L.S., Fitzpatrick, T.M., Bloom, M.F., Ramwell, P.W., Rose, J.C., Kot, P.A. Circ. Res. (1979) [Pubmed]
  26. Decrease in the protein kinase C-catalyzed phosphorylation of an endogenous lung protein (Mr 36,000) following treatment of mice with the tumor-modulatory agent butylated hydroxytoluene. Malkinson, A.M., Beer, D.S., Sadler, A.J., Coffman, D.S. Cancer Res. (1985) [Pubmed]
  27. Role of single-breath carbon monoxide-diffusing capacity in monitoring the pulmonary effects of bleomycin in germ cell tumor patients. Comis, R.L., Kuppinger, M.S., Ginsberg, S.J., Crooke, S.T., Gilbert, R., Auchincloss, J.H., Prestayko, A.W. Cancer Res. (1979) [Pubmed]
  28. Pulmonary effects of topical timolol. Charan, N.B., Lakshminarayan, S. Arch. Intern. Med. (1980) [Pubmed]
  29. Salbutamol inhibits pulmonary effects of platelet activating factor in man. Roca, J., Félez, M.A., Chung, K.F., Barberà, J.A., Rotger, M., Santos, C., Rodriguez-Roisin, R. Am. J. Respir. Crit. Care Med. (1995) [Pubmed]
  30. Endothelin: systemic arterial and pulmonary effects of a new peptide with potent biologic properties. Lüscher, T.F. Am. Rev. Respir. Dis. (1992) [Pubmed]
  31. EGR1 is a novel target for AhR agonists in human lung epithelial cells. Martinez, J.M., Baek, S.J., Mays, D.M., Tithof, P.K., Eling, T.E., Walker, N.J. Toxicol. Sci. (2004) [Pubmed]
  32. Plasma interleukin-1 alpha and beta, tumor necrosis factor-alpha, and lipopolysaccharide concentrations during pulmonary exacerbations of cystic fibrosis. Wilmott, R.W., Frenzke, M., Kociela, V., Peng, L. Pediatr. Pulmonol. (1994) [Pubmed]
  33. Calcitonin gene-related peptide as inflammatory mediator. Springer, J., Geppetti, P., Fischer, A., Groneberg, D.A. Pulmonary pharmacology & therapeutics. (2003) [Pubmed]
  34. Drug-induced bronchopulmonary pleural disease. Rosenow, E.C. J. Allergy Clin. Immunol. (1987) [Pubmed]
  35. Systemic and pulmonary effects of fluticasone administered through a metered-dose inhaler in rats. Sorkness, R.L., Remus, J.L., Rosenthal, L.A. J. Allergy Clin. Immunol. (2004) [Pubmed]
  36. Effect of Fluosol-DA/O2 on the antitumor activity and pulmonary toxicity of bleomycin. Teicher, B.A., Lazo, J.S., Merrill, W.W., Filderman, A.E., Rose, C.M. Cancer Chemother. Pharmacol. (1986) [Pubmed]
  37. A comparison of plethysmography, spirometry and oscillometry for assessing the pulmonary effects of inhaled ipratropium bromide in healthy subjects and patients with asthma. Houghton, C.M., Woodcock, A.A., Singh, D. British journal of clinical pharmacology. (2005) [Pubmed]
  38. Neoplastic effect of vinyl chloride in mouse lung--lower doses and short-term exposure. Suzuki, Y. Environmental research. (1983) [Pubmed]
  39. Celiprolol, atenolol and propranolol: a comparison of pulmonary effects in asthmatic patients. Doshan, H.D., Rosenthal, R.R., Brown, R., Slutsky, A., Applin, W.J., Caruso, F.S. J. Cardiovasc. Pharmacol. (1986) [Pubmed]
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