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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Workplace

  • To test the prognostic value of plasma renin activity prospectively, we determined the pretreatment renin-sodium profile of 1717 subjects with mild-to-moderate hypertension (mean age, 53 years; 36 percent white; 67 percent men) in a systematic work-site treatment program [1].
  • We conclude that zirconium should be considered a likely cause of pneumoconiosis and that appropriate precautions should be taken in the workplace [2].
  • On October 4, 2001, we confirmed the first bioterrorism-related anthrax case identified in the United States in a resident of Palm Beach County, Florida. Epidemiologic investigation indicated that exposure occurred at the workplace through intentionally contaminated mail [3].
  • Treatment of acute migraine attacks with oral or subcutaneous sumatriptan leads to less loss of workplace productivity than other antimigraine therapies [4].
  • A 23-year-old spray painter developed contact dermatitis and respiratory difficulty characterized by small airways obstruction shortly after the polyfunctional aziridine cross-linker CX-100 began to be used in his workplace as a paint activator [5].

Psychiatry related information on Workplace


High impact information on Workplace

  • The presence of smokers in both the home and the workplace also increased the cotinine levels [11].
  • RESULTS--Worksite smoking policy had a major effect on the nicotine concentrations, which fell from a median of 8.6 micrograms/m3 in the open offices at worksites that allowed smoking to 1.3 micrograms/m3 in sites that restricted smoking, and to 0.3 microgram/m3 in worksites that banned smoking [12].
  • A clinical epidemiologic study was conducted to determine the long-term health effects of workplace exposure to the process of manufacturing the herbicide (2,4,5-trichlorophenoxy)acetic acid including contaminants such as 2,3,7,8-tetrachlorodibenzo-rho-dioxin [13].
  • Personal air sample measurements showed that airborne concentrations of aniline and o-toluidine were well within the limits allowed in the workplace by OSHA [14].
  • PURPOSE: Our goal was to assess whether levels of cotinine and polycyclic aromatic hydrocarbon-albumin (PAH-albumin) are associated with ETS exposure in children and in women of reproductive age, after accounting for background exposures to PAHs in the diet, workplace, and the home environment [15].

Chemical compound and disease context of Workplace

  • SETTING: Work site in Osaka, Japan. PARTICIPANTS: 1,266 Japanese male office workers 35 to 59 years of age who did not have impaired fasting glucose or type 2 diabetes and were not taking medication for hypertension at study entry [16].
  • Occupational exposure to hydrogen sulfide is one of the leading causes of sudden death in the workplace, especially in the oil and gas industry [17].
  • Inhalation of dust from hard metal (HM), a mixture of tungsten carbide, cobalt, and other metals, can cause interstitial alveolitis, fibrosis, and asthma in the workplace [18].
  • Vaccines to prevent hepatitis B infection became available in 1982, and were recommended primarily for adults considered at high risk because of exposure in the workplace or lifestyles that lead to sexual or parenteral exposure to the virus [19].
  • METHODS: Prospective, open-label study at 27 work sites of 20 companies representing diverse labor sectors in Spain. Eligible patients according International Headache Society (IHS) criteria were recruited for the study by on-site physicians and instructed to treat moderate or severe migraine attacks with one tablet of rizatriptan 10 mg [20].

Biological context of Workplace


Anatomical context of Workplace


Associations of Workplace with chemical compounds

  • SETTING: academic medical center, Occupational Medicine Clinic, and worksite [31].
  • Evaluation of the worksite showed that dimethylformamide, a widely used industrial solvent and known hepatotoxin, was being used to coat fabric in poorly ventilated areas without appropriate skin protection [31].
  • SUBJECTS AND METHODS: Study subjects were 115 employees who had previously participated in worksite total cholesterol screening, selected by stratified random sampling for sex and total cholesterol levels [32].
  • Comments on "Respiratory effects of toluene diisocyanate in the workplace: a discussion of exposure-response relationships" [33].
  • Data collected included medical as well as pharmacy claims and patient surveys to measure changes in satisfaction, health-related quality of life, workplace productivity, and nonworkplace activity after sumatriptan therapy was initiated [34].

Gene context of Workplace

  • Because liver CYP1A2 levels are known to vary more than 60-fold between humans, our findings may be relevant to patients who are exposed to arylamines in the workplace [35].
  • The average level of the CYP1B1 mRNA in workers at the top work site, where the PAH exposure level from the coke ovens was highest, was significantly higher than in workers at the middle site (P<0.01) or the controls (P=0.02) [36].
  • Among never smokers, CYP2A6 genotypes were not correlated with exposure to passive smoking at home or in the workplace (p = 0.623 and 0.484, respectively) [37].
  • Thus far there is little information on p53 mutations in cancers of factory workers with a history of carcinogen exposure in the workplace [38].
  • Although screening for hemochromatosis has been recommended, workplace screening programs remain uncommon [39].

Analytical, diagnostic and therapeutic context of Workplace


  1. Association of the renin-sodium profile with the risk of myocardial infarction in patients with hypertension. Alderman, M.H., Madhavan, S., Ooi, W.L., Cohen, H., Sealey, J.E., Laragh, J.H. N. Engl. J. Med. (1991) [Pubmed]
  2. Zirconium compound-induced pulmonary fibrosis. Bartter, T., Irwin, R.S., Abraham, J.L., Dascal, A., Nash, G., Himmelstein, J.S., Jederlinic, P.J. Arch. Intern. Med. (1991) [Pubmed]
  3. First case of bioterrorism-related inhalational anthrax in the United States, Palm Beach County, Florida, 2001. Traeger, M.S., Wiersma, S.T., Rosenstein, N.E., Malecki, J.M., Shepard, C.W., Raghunathan, P.L., Pillai, S.P., Popovic, T., Quinn, C.P., Meyer, R.F., Zaki, S.R., Kumar, S., Bruce, S.M., Sejvar, J.J., Dull, P.M., Tierney, B.C., Jones, J.D., Perkins, B.A. Emerging Infect. Dis. (2002) [Pubmed]
  4. Sumatriptan. An updated review of its use in migraine. Perry, C.M., Markham, A. Drugs (1998) [Pubmed]
  5. Occupational asthma and contact dermatitis in a spray painter after introduction of an aziridine cross-linker. Leffler, C.T., Milton, D.K. Environ. Health Perspect. (1999) [Pubmed]
  6. Measuring physician job satisfaction in a changing workplace and a challenging environment. SGIM Career Satisfaction Study Group. Society of General Internal Medicine. Konrad, T.R., Williams, E.S., Linzer, M., McMurray, J., Pathman, D.E., Gerrity, M., Schwartz, M.D., Scheckler, W.E., Van Kirk, J., Rhodes, E., Douglas, J. Medical care. (1999) [Pubmed]
  7. The Alcohol Use Disorders Identification Test (AUDIT) and carbohydrate-deficient transferrin (CDT) in a routine workplace health examination. Hermansson, U., Helander, A., Huss, A., Brandt, L., Rönnberg, S. Alcohol. Clin. Exp. Res. (2000) [Pubmed]
  8. Competition/cooperation in worksite smoking cessation using nicotine gum. Maheu, M.M., Gevirtz, R.N., Sallis, J.F., Schneider, N.G. Preventive medicine. (1989) [Pubmed]
  9. Psychosis following styrene exposure: a case report of neuropsychological sequelae. White, D.M., Daniell, W.E., Maxwell, J.K., Townes, B.D. Journal of clinical and experimental neuropsychology : official journal of the International Neuropsychological Society. (1990) [Pubmed]
  10. Use of eating-pattern messages to evaluate changes in eating behaviors in a worksite cholesterol education program. Hartman, T.J., McCarthy, P.R., Himes, J.H. Journal of the American Dietetic Association. (1993) [Pubmed]
  11. Effects of environmental tobacco smoke on urinary cotinine excretion in nonsmokers. Evidence for passive smoking. Matsukura, S., Taminato, T., Kitano, N., Seino, Y., Hamada, H., Uchihashi, M., Nakajima, H., Hirata, Y. N. Engl. J. Med. (1984) [Pubmed]
  12. Occupational exposure to environmental tobacco smoke. Hammond, S.K., Sorensen, G., Youngstrom, R., Ockene, J.K. JAMA (1995) [Pubmed]
  13. Human health effects of 2,4,5-T and its toxic contaminants. Suskind, R.R., Hertzberg, V.S. JAMA (1984) [Pubmed]
  14. Monitoring of aromatic amine exposures in workers at a chemical plant with a known bladder cancer excess. Ward, E.M., Sabbioni, G., DeBord, D.G., Teass, A.W., Brown, K.K., Talaska, G.G., Roberts, D.R., Ruder, A.M., Streicher, R.P. J. Natl. Cancer Inst. (1996) [Pubmed]
  15. Biomarkers of environmental tobacco smoke in preschool children and their mothers. Crawford, F.G., Mayer, J., Santella, R.M., Cooper, T.B., Ottman, R., Tsai, W.Y., Simon-Cereijido, G., Wang, M., Tang, D., Perera, F.P. J. Natl. Cancer Inst. (1994) [Pubmed]
  16. Cigarette smoking and risk for impaired fasting glucose and type 2 diabetes in middle-aged Japanese men. Nakanishi, N., Nakamura, K., Matsuo, Y., Suzuki, K., Tatara, K. Ann. Intern. Med. (2000) [Pubmed]
  17. Sulfide toxicity: mechanical ventilation and hypotension determine survival rate and brain necrosis. Baldelli, R.J., Green, F.H., Auer, R.N. J. Appl. Physiol. (1993) [Pubmed]
  18. Hard metal-induced disease: effects of metal cations in vitro on guinea pig isolated airways. Fedan, J.S., Cutler, D. Toxicol. Appl. Pharmacol. (2001) [Pubmed]
  19. Vaccines to prevent hepatitis B and hepatitis A virus infections. Hadler, S.C. Infect. Dis. Clin. North Am. (1990) [Pubmed]
  20. Effects on productivity and quality of life of rizatriptan for acute migraine: a workplace study. Láinez, M.J., López, A., Pascual, A.M. Headache. (2005) [Pubmed]
  21. Walking to work and the risk for hypertension in men: the Osaka Health Survey. Hayashi, T., Tsumura, K., Suematsu, C., Okada, K., Fujii, S., Endo, G. Ann. Intern. Med. (1999) [Pubmed]
  22. Molecular genetics of lung cancer. Sekido, Y., Fong, K.M., Minna, J.D. Annu. Rev. Med. (2003) [Pubmed]
  23. Latex sensitivity: an industrial hygiene perspective. Reiter, J.E. J. Allergy Clin. Immunol. (2002) [Pubmed]
  24. Acid stress in the pathology of asthma. Ricciardolo, F.L., Gaston, B., Hunt, J. J. Allergy Clin. Immunol. (2004) [Pubmed]
  25. Human leukocyte antigen associations in occupational asthma induced by isocyanates. Mapp, C.E., Balboni, A., Baricordi, R., Fabbri, L.M. Am. J. Respir. Crit. Care Med. (1997) [Pubmed]
  26. Erythrocyte glucose-6-phosphate dehydrogenase deficiency does not pose an increased risk for black Americans exposed to oxidant gases in the workplace or general environment. Goldstein, B.D., Amoruso, M.A., Witz, G. Toxicology and industrial health. (1985) [Pubmed]
  27. Radiation exposure from work-related medical X-rays at the Portsmouth Naval Shipyard. Daniels, R.D., Kubale, T.L., Spitz, H.B. Am. J. Ind. Med. (2005) [Pubmed]
  28. Inflammatory and cytotoxic potential of the airborne particle material assessed by nasal lavage and cell exposure methods. Roponen, M., Toivola, M., Alm, S., Nevalainen, A., Jussila, J., Hirvonen, M.R. Inhalation toxicology. (2003) [Pubmed]
  29. Monocyte CD14 response following endotoxin exposure in cotton spinners and office workers. Fishwick, D., Raza, S.N., Beckett, P., Swan, J.R., Pickering, C.A., Fletcher, A.M., Niven, R.M., Francis, H., Rawbone, R., Curran, A.D. Am. J. Ind. Med. (2002) [Pubmed]
  30. Carbon monoxide exposures in Australian workplaces could precipitate myocardial ischaemia in smoking workers with coronary artery disease. Wickramatillake, H.D., Gun, R.T., Ryan, P. Australian and New Zealand journal of public health. (1998) [Pubmed]
  31. Liver disease associated with occupational exposure to the solvent dimethylformamide. Redlich, C.A., Beckett, W.S., Sparer, J., Barwick, K.W., Riely, C.A., Miller, H., Sigal, S.L., Shalat, S.L., Cullen, M.R. Ann. Intern. Med. (1988) [Pubmed]
  32. The effect of fasting status on the determination of low-density and high-density lipoprotein cholesterol. Wilder, L.B., Bachorik, P.S., Finney, C.A., Moy, T.F., Becker, D.M. Am. J. Med. (1995) [Pubmed]
  33. Comments on "Respiratory effects of toluene diisocyanate in the workplace: a discussion of exposure-response relationships". Högberg, J., Larsson, K., Albin, M., Järvholm, B., Montelius, J. Crit. Rev. Toxicol. (2005) [Pubmed]
  34. Changes in resource use and outcomes for patients with migraine treated with sumatriptan: a managed care perspective. Lofland, J.H., Johnson, N.E., Batenhorst, A.S., Nash, D.B. Arch. Intern. Med. (1999) [Pubmed]
  35. Decrease in 4-aminobiphenyl-induced methemoglobinemia in Cyp1a2(-/-) knockout mice. Shertzer, H.G., Dalton, T.P., Talaska, G., Nebert, D.W. Toxicol. Appl. Pharmacol. (2002) [Pubmed]
  36. Cytochrome P450 1B1 mRNA levels in peripheral blood cells and exposure to polycyclic aromatic hydrocarbons in Chinese coke oven workers. Hanaoka, T., Yamano, Y., Pan, G., Hara, K., Ichiba, M., Zhang, J., Zhang, S., Liu, T., Li, L., Takahashi, K., Kagawa, J., Tsugane, S. Sci. Total Environ. (2002) [Pubmed]
  37. Association of CYP2A6 gene deletion with cigarette smoking status in Japanese adults. Ando, M., Hamajima, N., Ariyoshi, N., Kamataki, T., Matsuo, K., Ohno, Y. Journal of epidemiology / Japan Epidemiological Association. (2003) [Pubmed]
  38. p53 mutations at A:T base pairs in angiosarcomas of vinyl chloride-exposed factory workers. Hollstein, M., Marion, M.J., Lehman, T., Welsh, J., Harris, C.C., Martel-Planche, G., Kusters, I., Montesano, R. Carcinogenesis (1994) [Pubmed]
  39. Evaluation of a workplace hemochromatosis screening program. Stave, G.M., Mignogna, J.J., Powell, G.S., Hunt, C.M. American journal of preventive medicine. (1999) [Pubmed]
  40. Longitudinal study of negative workplace events among employed rheumatoid arthritis patients and healthy controls. Mancuso, C.A., Rincon, M., Sayles, W., Paget, S.A. Arthritis Rheum. (2005) [Pubmed]
  41. Occupational asthma in a technologist exposed to glutaraldehyde. Chan-Yeung, M., McMurren, T., Catonio-Begley, F., Lam, S. J. Allergy Clin. Immunol. (1993) [Pubmed]
  42. The metabolic syndrome in Hong Kong Chinese. The interrelationships among its components analyzed by structural equation modeling. Chan, J.C., Cheung, J.C., Lau, E.M., Wooà, J., Chan, A.Y., Swaminathan, R., Cockrama, C.S. Diabetes Care (1996) [Pubmed]
  43. Adulteration of urine by "Urine Luck". Wu, A.H., Bristol, B., Sexton, K., Cassella-McLane, G., Holtman, V., Hill, D.W. Clin. Chem. (1999) [Pubmed]
  44. Effects on alcohol use and anxiety of the September 11, 2001, attacks and chronic work stressors: a longitudinal cohort study. Richman, J.A., Wislar, J.S., Flaherty, J.A., Fendrich, M., Rospenda, K.M. American journal of public health. (2004) [Pubmed]
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