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Chemical Compound Review:

Vapiprost HCl (E)-7-[(1R,2R,3S,5S)-3- hydroxy-5-[(4...

Synonyms: AC1O5JU9, GR 32191B, 87248-13-3, UNII-292V8Q1MXQ

This record was replaced with 6436588.

Liu, K.L. et al., Horie, S. et al., Matsuzaki, T. et al.

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High impact information on VAPIPROST

The inhibitory effects of vapiprost hydrochloride (vapiprost), a novel thromboxane A2 receptor antagonist, on platelet aggregation and ATP release were studied using platelet rich plasma (PRP) of humans, guinea pigs, rabbits and rats [1].
The influence of renal perfusion pressure (RPP) on renal functions was studied in anesthetized 8-wk-old Lyon hypertensive (LH) and normotensive (LN) rats before and after a specific blockade of prostaglandin (PG) H2-thromboxane (Tx) A2 receptors using GR-32191B [2].
Effects of the new thromboxane A2 antagonist vapiprost (SN-309, GR-32191B, CAS 85505-64-2) on isolated canine blood vessels were investigated [3].

References

The potent inhibition of vapiprost, a novel thromboxane A2 receptor antagonist, on the secondary aggregation and ATP release of human platelets. Horie, S., Yamada, M., Satoh, M., Noritake, S., Hiraishi, S., Kizaki, K., Kurusu, O., Nakahara, T., Ishii, H., Kazama, M. Biol. Pharm. Bull. (1997) [Pubmed]
Prostaglandin H2-thromboxane A2 and renal functions in the Lyon hypertensive rat. Liu, K.L., Benzoni, D., Sassard, J. Am. J. Physiol. (1994) [Pubmed]
Effects of the new thromboxane A2 antagonist vapiprost on isolated canine blood vessels. Matsuzaki, T., Noguchi, K., Nakasone, J., Uezu, K., Higuchi, M., Sakanashi, M. Arzneimittel-Forschung. (1992) [Pubmed]

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