Disease relevance of vicenistatin

• Vicenistatin, an antitumor antibiotic isolated from Streptomyces halstedii, is a unique 20-membered macrocyclic lactam with a novel aminosugar vicenisamine [1].

High impact information on vicenistatin

• The vicenistatin biosynthetic gene cluster (vin) spanning approximately 64 kbp was cloned and sequenced [1].
• In the January issue of Chemistry & Biology, Kakinuma and coworkers reported on the vicenistatin biosynthetic gene cluster and demonstrated in vitro glycosylation of its aglycone core, raising the possibility of producing analogs with altered sugar residues [2].
• A unique feature of the vicenistatin PKS is that the loading module contains only an acyl carrier protein domain, in contrast to other known PKS-loading modules containing certain activation domains [1].

Associations of vicenistatin with other chemical compounds

• The vinI gene in the vicenistatin biosynthetic gene cluster encoding glutamate mutase, which rearranges glutamate to 3-methylaspartate, was disrupted [3].

Analytical, diagnostic and therapeutic context of vicenistatin

• Vicenistatin exhibited antitumor activity against human colon carcinoma Co-3 in the xenograft model [4].

References