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Chemical Compound Review:

CHEMBL277077 ethyl(E)-3-(2,5- dihydroxyphenyl)prop-2...

Synonyms: SureCN3366448, AC1O5VNZ, 2,5-Mec

Takahashi, K. et al., Han, Y. et al., Kawada, M. et al.

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Disease relevance of Ethyl 2,5-dihydroxycinnamate

Preferential inhibition of glioblastoma cells with wild-type epidermal growth factor receptors by a novel tyrosine kinase inhibitor ethyl-2,5-dihydroxycinnamate [1].

High impact information on Ethyl 2,5-dihydroxycinnamate

Whereas the increases in DNA synthesis and p53 phosphorylation were inhibited by antibody to the IGF-I receptor and by 2,5-Mec, the nuclear exclusion of p53 was prevented by the antibody and also, although not significantly, by 2,5-Mec [2].
Among eight erbstatin analogues studied, ethyl 2,5-dihydroxycinnamate induced erythroid differentiation of K562 cells most effectively [3].

References

Preferential inhibition of glioblastoma cells with wild-type epidermal growth factor receptors by a novel tyrosine kinase inhibitor ethyl-2,5-dihydroxycinnamate. Han, Y., Caday, C.G., Umezawa, K., Nanda, A. Oncol. Res. (1997) [Pubmed]
Association of insulin-like growth-factor-I-induced DNA synthesis with phosphorylation and nuclear exclusion of p53 in human breast cancer MCF-7 cells. Takahashi, K., Suzuki, K. Int. J. Cancer (1993) [Pubmed]
Inhibition of Abelson oncogene function by erbstatin analogues. Kawada, M., Tawara, J., Tsuji, T., Honma, Y., Hozumi, M., Wang, J.Y., Umezawa, K. Drugs under experimental and clinical research. (1993) [Pubmed]

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