Chemical Compound Review:
Erbstatin N-[(E)-2-(2,5- dihydroxyphenyl) ethenyl]meth...
Synonyms:
CHEMBL47986, NSC-606641, NSC-610187, LS-69467, NSC606641, ...
- Induction of morphological change by tyrosine kinase inhibitors in Rous sarcoma virus-transformed rat kidney cells. Umezawa, K., Tanaka, K., Hori, T., Abe, S., Sekizawa, R., Imoto, M. FEBS Lett. (1991)
- Antitumor activity of erbstatin, a tyrosine protein kinase inhibitor. Imoto, M., Umezawa, K., Komuro, K., Sawa, T., Takeuchi, T., Umezawa, H. Jpn. J. Cancer Res. (1987)
- Induction of morphological and enzymic differentiation in rat pheochromocytoma PC12h cells by stable erbstatin analogues. Watanabe, Y., Kakeya, H., Ikoma, E., Umezawa, K. Drugs under experimental and clinical research. (1993)
- The anti-proliferative effects of tyrosine kinase inhibitors towards tamoxifen-sensitive and tamoxifen-resistant human breast cancer cell lines in relation to the expression of epidermal growth factor receptors (EGF-R) and the inhibition of EGF-R tyrosine kinase. El-Zarruk, A.A., van den Berg, H.W. Cancer Lett. (1999)
- Tyrosine kinase inhibitors can differentially inhibit integrin-dependent and CAM-stimulated neurite outgrowth. Williams, E.J., Walsh, F.S., Doherty, P. J. Cell Biol. (1994)
- Ca2+-independent activation of the endothelial nitric oxide synthase in response to tyrosine phosphatase inhibitors and fluid shear stress. Fleming, I., Bauersachs, J., Fisslthaler, B., Busse, R. Circ. Res. (1998)
- Regulation of stimulated integrin surface expression in human neutrophils by tyrosine phosphorylation. Naccache, P.H., Jean, N., Liao, N.W., Bator, J.M., McColl, S.R., Kubes, P. Blood (1994)
- Involvement of tyrosine kinases in the activation of human peripheral blood neutrophils by granulocyte-macrophage colony-stimulating factor. McColl, S.R., DiPersio, J.F., Caon, A.C., Ho, P., Naccache, P.H. Blood (1991)
- Selective inhibition of human neutrophil functional responsiveness by erbstatin, an inhibitor of tyrosine protein kinase. Naccache, P.H., Gilbert, C., Caon, A.C., Gaudry, M., Huang, C.K., Bonak, V.A., Umezawa, K., McColl, S.R. Blood (1990)
- Involvement of hydrogen peroxide production in erbstatin-induced apoptosis in human small cell lung carcinoma cells. Simizu, S., Imoto, M., Masuda, N., Takada, M., Umezawa, K. Cancer Res. (1996)
- Effects of protein tyrosine kinase inhibitors on egg activation and fertilization-dependent protein tyrosine kinase activity. Moore, K.L., Kinsey, W.H. Dev. Biol. (1995)
- Induction of hydrogen peroxide production and Bax expression by caspase-3(-like) proteases in tyrosine kinase inhibitor-induced apoptosis in human small cell lung carcinoma cells. Simizu, S., Umezawa, K., Takada, M., Arber, N., Imoto, M. Exp. Cell Res. (1998)
- Tyrosine phosphorylation is involved in reorganization of the actin cytoskeleton in response to serum or LPA stimulation. Chrzanowska-Wodnicka, M., Burridge, K. J. Cell. Sci. (1994)
- Effects of tyrosine kinase inhibitor, erbstatin, on cell growth and growth-factor/receptor gene expression in human gastric carcinoma cells. Takekura, N., Yasui, W., Kyo, E., Yoshida, K., Kameda, T., Kitadai, Y., Abe, K., Umezawa, K., Tahara, E. Int. J. Cancer (1991)
- Insulin stimulation of Na/H antiport in L-6 cells: a different mechanism in myoblasts and myotubes. Incerpi, S., Rizvi, S.I., De Vito, P., Luly, P. J. Cell. Physiol. (1997)
- Thapsigargin-induced calcium influx in the absence of detectable tyrosine phosphorylation in human platelets. Vostal, J.G., Shafer, B. J. Biol. Chem. (1996)
- Chemotactic peptide-induced activation of Ras in human neutrophils is associated with inhibition of p120-GAP activity. Zheng, L., Eckerdal, J., Dimitrijevic, I., Andersson, T. J. Biol. Chem. (1997)
- Modulation of the Kv1.3 potassium channel by receptor tyrosine kinases. Bowlby, M.R., Fadool, D.A., Holmes, T.C., Levitan, I.B. J. Gen. Physiol. (1997)
- Thrombin receptor expression is increased by angiotensin II in cultured and native vascular smooth muscle cells. Fisslthaler, B., Schini-Kerth, V.B., Fleming, I., Busse, R. Cardiovasc. Res. (1998)
- Erbstatin blocks platelet activating factor-induced protein-tyrosine phosphorylation, polyphosphoinositide hydrolysis, protein kinase C activation, serotonin secretion and aggregation of rabbit platelets. Salari, H., Duronio, V., Howard, S.L., Demos, M., Jones, K., Reany, A., Hudson, A.T., Pelech, S.L. FEBS Lett. (1990)
- Kinetics of inhibition by tyrphostins of the tyrosine kinase activity of the epidermal growth factor receptor and analysis by a new computer program. Posner, I., Engel, M., Gazit, A., Levitzki, A. Mol. Pharmacol. (1994)
- Chemotactic peptides induce phosphorylation and activation of MEK-1 in human neutrophils. Grinstein, S., Butler, J.R., Furuya, W., L'Allemain, G., Downey, G.P. J. Biol. Chem. (1994)
- Inhibition of DNA topoisomerases I and II and induction of apoptosis by erbstatin and tyrphostin derivatives. Markovits, J., Larsen, A.K., Ségal-Bendirdjian, E., Fossé, P., Saucier, J.M., Gazit, A., Levitzki, A., Umezawa, K., Jacquemin-Sablon, A. Biochem. Pharmacol. (1994)