Gene Review:
IGF1R - insulin-like growth factor 1 receptor
Homo sapiens
Synonyms:
CD221, IGF-I receptor, IGFIR, IGFR, Insulin-like growth factor 1 receptor, ...
Abu-Amero,
Vaughan,
Bennett,
Ali,
Moore,
Garcia,
Wonnacott,
Soderkvist,
Nagga,
Marcusson,
Sutcliffe,
Ahmadi,
Raile,
Keller,
Keller,
Kratzsch,
Smith,
Schneider,
Pfäffle,
Kiess,
Laue,
Klammt,
McMullen,
Tarnavski,
Kong,
Izumo,
Brown,
Bisping,
Schinke,
Sherwood,
Shioi,
Riggi,
Zhang,
Kang,
Huang,
Misra,
Ghatak,
Toole,
Smith,
Xu,
Kinose,
Zhang,
Robinson,
Driver,
Bischoff,
Soker,
Senger,
Shen,
Perruzzi,
Schaeffer,
Ellis,
Taylor,
Jenkins,
Leek,
Harris,
Siddle,
Redington,
Hanfelt,
Götz,
Jäger,
Lossdörfer,
Heinen,
Götz,
Krüger,
Ragotzki,
Jäger,
Lossdörfer,
Fang,
Jiang,
Shi,
Zhou,
- The insulin-like growth factor 1 receptor gene is normally biallelically expressed in human juvenile tissue and tumours. Howard, T.K., Algar, E.M., Glatz, J.A., Reeve, A.E., Smith, P.J. Hum. Mol. Genet. (1993)
- Down-regulation of insulin receptor by antibodies against the type I insulin-like growth factor receptor: implications for anti-insulin-like growth factor therapy in breast cancer. Sachdev, D., Singh, R., Fujita-Yamaguchi, Y., Yee, D. Cancer Res. (2006)
- Expression of the type 1 insulin-like growth factor receptor is up-regulated in primary prostate cancer and commonly persists in metastatic disease. Hellawell, G.O., Turner, G.D., Davies, D.R., Poulsom, R., Brewster, S.F., Macaulay, V.M. Cancer Res. (2002)
- The insulin-like growth factor 1 receptor induces physiological heart growth via the phosphoinositide 3-kinase(p110alpha) pathway. McMullen, J.R., Shioi, T., Huang, W.Y., Zhang, L., Tarnavski, O., Bisping, E., Schinke, M., Kong, S., Sherwood, M.C., Brown, J., Riggi, L., Kang, P.M., Izumo, S. J. Biol. Chem. (2004)
- Genomic and molecular characterization of malignant peripheral nerve sheath tumor identifies the IGF1R pathway as a primary target for treatment. Yang, J., Ylipää, A., Sun, Y., Zheng, H., Chen, K., Nykter, M., Trent, J., Ratner, N., Lev, D.C., Zhang, W. Clin. Cancer Res. (2011)
- Association of insulin-like growth factor-1 receptor polymorphism in dementia. Garcia, J., Ahmadi, A., Wonnacott, A., Sutcliffe, W., Nagga, K., Soderkvist, P., Marcusson, J. Dementia and geriatric cognitive disorders (2006)
- Blockade of the insulin-like growth factor I receptor in the choroid plexus originates Alzheimer's-like neuropathology in rodents: new cues into the human disease? Carro, E., Trejo, J.L., Spuch, C., Bohl, D., Heard, J.M., Torres-Aleman, I. Neurobiol. Aging (2006)
- Insulin-like growth factor-I receptor densities in human frontal cortex and white matter during aging, in Alzheimer's disease, and in Huntington's disease. De Keyser, J., Wilczak, N., Goossens, A. Neurosci. Lett. (1994)
- IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Holzenberger, M., Dupont, J., Ducos, B., Leneuve, P., Géloën, A., Even, P.C., Cervera, P., Le Bouc, Y. Nature (2003)
- Regulation of vascular endothelial growth factor-dependent retinal neovascularization by insulin-like growth factor-1 receptor. Smith, L.E., Shen, W., Perruzzi, C., Soker, S., Kinose, F., Xu, X., Robinson, G., Driver, S., Bischoff, J., Zhang, B., Schaeffer, J.M., Senger, D.R. Nat. Med. (1999)
- Stimulation of tyrosine-specific phosphorylation in vitro by insulin-like growth factor I. Rubin, J.B., Shia, M.A., Pilch, P.F. Nature (1983)
- Growth-stimulatory actions of insulin in vitro and in vivo. Straus, D.S. Endocr. Rev. (1984)
- A new concept in neurodegeneration: TNFalpha is a silencer of survival signals. Venters, H.D., Dantzer, R., Kelley, K.W. Trends Neurosci. (2000)
- Insulin-like growth factors in human breast cancer. Ellis, M.J., Jenkins, S., Hanfelt, J., Redington, M.E., Taylor, M., Leek, R., Siddle, K., Harris, A. Breast Cancer Res. Treat. (1998)
- Expression of the insulin-like growth factors and their receptors in term placentas: a comparison between normal and IUGR births. Abu-Amero, S.N., Ali, Z., Bennett, P., Vaughan, J.I., Moore, G.E. Mol. Reprod. Dev. (1998)
- IGF-1 receptor tyrosine kinase inhibition by the cyclolignan PPP induces G2/M-phase accumulation and apoptosis in multiple myeloma cells. Strömberg, T., Ekman, S., Girnita, L., Dimberg, L.Y., Larsson, O., Axelson, M., Lennartsson, J., Hellman, U., Carlson, K., Osterborg, A., Vanderkerken, K., Nilsson, K., Jernberg-Wiklund, H. Blood (2006)
- The cyclolignan PPP induces activation loop-specific inhibition of tyrosine phosphorylation of the insulin-like growth factor-1 receptor. Link to the phosphatidyl inositol-3 kinase/Akt apoptotic pathway. Vasilcanu, D., Girnita, A., Girnita, L., Vasilcanu, R., Axelson, M., Larsson, O. Oncogene (2004)
- Insulin-like growth factor-I receptor signaling in tamoxifen-resistant breast cancer: a supporting role to the epidermal growth factor receptor. Knowlden, J.M., Hutcheson, I.R., Barrow, D., Gee, J.M., Nicholson, R.I. Endocrinology (2005)
- A dominant negative type I insulin-like growth factor receptor inhibits metastasis of human cancer cells. Sachdev, D., Hartell, J.S., Lee, A.V., Zhang, X., Yee, D. J. Biol. Chem. (2004)
- Downregulation of the type 1 insulin-like growth factor receptor in mouse melanoma cells is associated with enhanced radiosensitivity and impaired activation of Atm kinase. Macaulay, V.M., Salisbury, A.J., Bohula, E.A., Playford, M.P., Smorodinsky, N.I., Shiloh, Y. Oncogene (2001)
- Clinical and functional characteristics of the human Arg59Ter insulin-like growth factor i receptor (IGF1R) mutation: implications for a gene dosage effect of the human IGF1R. Raile, K., Klammt, J., Schneider, A., Keller, A., Laue, S., Smith, R., Pfäffle, R., Kratzsch, J., Keller, E., Kiess, W. J. Clin. Endocrinol. Metab. (2006)
- Ataxia telangiectasia mutated (Atm) knockout mice as a model of osteopenia due to impaired bone formation. Hishiya, A., Ito, M., Aburatani, H., Motoyama, N., Ikeda, K., Watanabe, K. Bone (2005)
- Multiple signaling pathways are activated during insulin-like growth factor-I (IGF-I) stimulated breast cancer cell migration. Zhang, X., Lin, M., van Golen, K.L., Yoshioka, K., Itoh, K., Yee, D. Breast Cancer Res. Treat. (2005)
- Expression of mRNA for the insulin-like growth factors and their receptors in human preimplantation embryos. Lighten, A.D., Hardy, K., Winston, R.M., Moore, G.E. Mol. Reprod. Dev. (1997)
- Immunohistochemical localization of components of the insulin-like growth factor-system in human deciduous teeth. Götz, W., Krüger, U., Ragotzki, S., Lossdörfer, S., Jäger, A. Connect. Tissue Res. (2001)
- Immunohistochemical localization of components of the insulin-like growth factor system in human permanent teeth. Götz, W., Heinen, M., Lossdörfer, S., Jäger, A. Arch. Oral Biol. (2006)
- Human melanoma cells expressing V600E B-RAF are susceptible to IGF1R targeting by small interfering RNAs. Yeh, A.H., Bohula, E.A., Macaulay, V.M. Oncogene (2006)
- IGF1R signalling and its inhibition. Riedemann, J., Macaulay, V.M. Endocr. Relat. Cancer (2006)
- Silencing of the IGF1R gene enhances sensitivity to DNA-damaging agents in both PTEN wild-type and mutant human prostate cancer. Rochester, M.A., Riedemann, J., Hellawell, G.O., Brewster, S.F., Macaulay, V.M. Cancer Gene Ther. (2005)
- Inhibition of insulin like growth factor II autocrine growth of Wilms' tumor by suramin in vitro and in vivo. Vincent, T.S., Hazen-Martin, D.J., Garvin, A.J. Cancer Lett. (1996)
- Differential expression of alternatively spliced mRNA forms of the insulin-like growth factor 1 receptor in human neuroendocrine tumors. Vitale, L., Lenzi, L., Huntsman, S.A., Canaider, S., Frabetti, F., Casadei, R., Facchin, F., Carinci, P., Zannotti, M., Coppola, D., Strippoli, P. Oncol. Rep. (2006)
- Insulin-like growth factor-I receptor mediates the prosurvival effect of fibronectin. Edderkaoui, M., Hong, P., Lee, J.K., Pandol, S.J., Gukovskaya, A.S. J. Biol. Chem. (2007)
- Positively charged side chains in the insulin-like growth factor-1 C- and D-regions determine receptor binding specificity. Zhang, W., Gustafson, T.A., Rutter, W.J., Johnson, J.D. J. Biol. Chem. (1994)
- Suppressor of cytokine signaling (SOCS)-3 protein interacts with the insulin-like growth factor-I receptor. Dey, B.R., Furlanetto, R.W., Nissley, P. Biochem. Biophys. Res. Commun. (2000)
- Signaling via the insulin-like growth factor-I receptor: does it differ from insulin receptor signaling? Blakesley, V.A., Scrimgeour, A., Esposito, D., Le Roith, D. Cytokine Growth Factor Rev. (1996)
- Down-regulation of Type I Insulin-like Growth Factor Receptor Increases Sensitivity of Breast Cancer Cells to Insulin. Zhang, H., Pelzer, A.M., Kiang, D.T., Yee, D. Cancer Res. (2007)
- RACK1 is an insulin-like growth factor 1 (IGF-1) receptor-interacting protein that can regulate IGF-1-mediated Akt activation and protection from cell death. Kiely, P.A., Sant, A., O'Connor, R. J. Biol. Chem. (2002)
- Proinflammatory cytokines block growth of breast cancer cells by impairing signals from a growth factor receptor. Shen, W.H., Zhou, J.H., Broussard, S.R., Freund, G.G., Dantzer, R., Kelley, K.W. Cancer Res. (2002)
- IL-1beta suppresses prolonged Akt activation and expression of E2F-1 and cyclin A in breast cancer cells. Shen, W.H., Jackson, S.T., Broussard, S.R., McCusker, R.H., Strle, K., Freund, G.G., Johnson, R.W., Dantzer, R., Kelley, K.W. J. Immunol. (2004)
- Luteolin inhibits insulin-like growth factor 1 receptor signaling in prostate cancer cells. Fang, J., Zhou, Q., Shi, X.L., Jiang, B.H. Carcinogenesis (2007)
- Insulin-like growth factor-1 activates Akt and Jun N-terminal kinases (JNKs) in promoting the survival of T lymphocytes. Walsh, P.T., Smith, L.M., O'Connor, R. Immunology (2002)
- Ontogenesis of somatomedin and insulin receptors in the human fetus. Sara, V.R., Hall, K., Misaki, M., Fryklund, L., Christensen, N., Wetterberg, L. J. Clin. Invest. (1983)
- Transactivation of the EGF receptor mediates IGF-1-stimulated shc phosphorylation and ERK1/2 activation in COS-7 cells. Roudabush, F.L., Pierce, K.L., Maudsley, S., Khan, K.D., Luttrell, L.M. J. Biol. Chem. (2000)
- Hyaluronan constitutively regulates activation of multiple receptor tyrosine kinases in epithelial and carcinoma cells. Misra, S., Toole, B.P., Ghatak, S. J. Biol. Chem. (2006)
- {beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase. Girnita, L., Shenoy, S.K., Sehat, B., Vasilcanu, R., Girnita, A., Lefkowitz, R.J., Larsson, O. J. Biol. Chem. (2005)
- External imaging of CCND1 cancer gene activity in experimental human breast cancer xenografts with 99mTc-peptide-peptide nucleic acid-peptide chimeras. Tian, X., Aruva, M.R., Qin, W., Zhu, W., Duffy, K.T., Sauter, E.R., Thakur, M.L., Wickstrom, E. J. Nucl. Med. (2004)
- The type-1 insulin-like growth factor receptor tyrosine kinase and breast cancer: biology and therapeutic relevance. Gross, J.M., Yee, D. Cancer Metastasis Rev. (2003)
- Overexpression of the insulin-like growth factor-1 receptor and autocrine stimulation in human cervical cancer cells. Steller, M.A., Delgado, C.H., Bartels, C.J., Woodworth, C.D., Zou, Z. Cancer Res. (1996)