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Chemical Compound Review:

Moducren (Z)-but-2-enedioate; 4-chloro-10,10-dioxo...

Synonyms: Moducrin, AC1O5W37, 73788-01-9

Obel, A.O., Burns, D.G. et al., Parry, E.E. et al., Middleton, R.S.

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Disease relevance of Moducrin

It is concluded that the fixed drug combination of timolol-hydrochlorothiazide-amiloride (Moducren) is effective in controlling mild to moderate hypertension in Africans and is better tolerated than methyldopa in these patients [1].

High impact information on Moducrin

A general practice study of timolol/hydrochlorothiazide/amiloride ('Moducren'), a new therapy for hypertension, and the doctor's influence on management [2].
The effect of a single dose of timolol, hydrochlorothiazide and amiloride in fixed combination (Moducren; MSD) in patients with mild to moderate essential hypertension was tested in an open study during 1978 [3].

Analytical, diagnostic and therapeutic context of Moducrin

Seventeen patients ranging in age from 67 to 86 years were entered into a double-blind, crossover study of Moducren and placebo [4].

References

A comparison of timolol plus hydrochlorothiazide plus amiloride and methyldopa in essential hypertension in Black Africans. Obel, A.O. Tropical and geographical medicine. (1983) [Pubmed]
A general practice study of timolol/hydrochlorothiazide/amiloride ('Moducren'), a new therapy for hypertension, and the doctor's influence on management. Parry, E.E., Arr, S., Tait, D. Pharmatherapeutica. (1983) [Pubmed]
Combination of timolol maleate, hydrochlorothiazide and amiloride hydrochloride in the treatment of hypertension: A multicentre trial. Burns, D.G., Pittaway, D. S. Afr. Med. J. (1980) [Pubmed]
Anti-hypertensive therapy in the elderly and its effects on cerebral function. Middleton, R.S. Mech. Ageing Dev. (1984) [Pubmed]

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