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MSD  -  microcephaly with spastic diplegia (Paine...

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Disease relevance of MSD

  • To evaluate the immunogenicity and safety of a 23-valent pneumococcal vaccine in human immunodeficiency virus (HIV)-seropositive patients, 80 men and 18 women received 1 dose of the vaccine (Pneumo 23; Pasteur Mérieux MSD, Brussels) [1].
  • The minimal UVA dose required to induce delayed erythema (minimal phototoxic dose or MPD) and the minimal UVA dose required to induce an immediate smarting reaction (minimal smarting dose or MSD) were recorded in 32 subjects in a variety of settings [2].
  • Health care personnel who received the hepatitis B vaccine (Heptavax-BR, MSD) were followed for persistence of hepatitis B surface antibody (anti-HBs) [3].
  • Patients also consumed a 13C-urea-rich meal (5 mg/kg body weight, 99% 13C, MSD Isotopes, Montreal Canada) [4].
  • The suitability of MEMB agar or MSD agar for recovery of E. coli O157:H7 from heated or frozen (-20 degrees C) low- or high-fat ground beef was determined [5].

Psychiatry related information on MSD


High impact information on MSD

  • Report on EFSD/MSD Travel Fellowship for Young Scientists 2001. % week stay at the MRC Phosphorylation Unit, University of Dundee [8].
  • We defined the renal hemodynamic and tubular actions and aldosterone responses to furosemide (40 mg, orally) in the presence of acute AT(1) receptor antagonism (losartan, MSD, 50 mg orally) vs. placebo in 10 subjects with CHF (New York Heart Association II-III) in a double-blind, placebo-controlled crossover study [9].
  • No prolongation of graft survival was observed in immunized animals that were treated with IL-2 alone (MSD = 10 +/- 1.4) [10].
  • Forty six patients received a topical application of a 0.3% norfloxacin (Zoroxin; MSD, Austria) solution into the lower fornix at different time intervals and frequencies before undergoing planned extracapsular cataract extraction [11].
  • Using HPLC, UV, and GC/MSD, a retinoid exhibiting identical chromatographic and spectral characteristics of isotretinoin was observed in the samples from the skin exposed to light, but was virtually absent in the skin samples maintained in the dark [12].

Chemical compound and disease context of MSD


Biological context of MSD

  • After sample extraction with acetonitrile, 14C-labeled biotransformation products (metabolites) were quantified by LC/ARC (on-line liquid chromatography/ accurate radioisotope counting) and identified by quadrupole time-of-flight (Q-TOF) mass spectrometry and GC/MSD (mass selective detector) [18].
  • MATERIALS AND METHODS: Plasma CETP concentrations at baseline and after 2 years' treatment with pravastatin or placebo were measured (n=674), and correlations with lipid and angiographic parameters (mean segment- and obstruction-diameter; MSD and MOD), and TaqIB genotype were studied [19].
  • Degradation of PCP involves dechlorination, methylation, carboxylation and ring cleavage as verified by GC-MSD and ion chromatography [20].
  • The study was undertaken in 1992. 'Young principals' who had attended MSD Foundation regional courses were invited by letter to reflect on recent change in general practice and to give their views on morale and recruitment [21].
  • A meeting was held at the European Bioinformatics Institute (EBI) in Hinxton, United Kingdom to discuss recent progress in the development of EMD, a database for maps determined by electron microscopy that is now integrated with MSD, the macromolecular structure database at EBI [22].

Anatomical context of MSD

  • A possible mechanism of myelin loss in MSD is discussed [23].
  • We compared the outcome of bone marrow transplantation (BMT) from HLA-identical siblings (MSD) and one HLA-locus mismatched siblings (PMSD) in Chinese patients with hematologic malignancies in terms of transplant-related mortality (TRM) and disease relapse to see whether PMSD can feasibly increase the availability of donors in our population [24].
  • A total of 94 children consecutively underwent allogeneic stem cell transplantation (SCT) from: matched-sibling (MSD) (n=36), mismatched-related (MMRD) (n=3) and unrelated donors (UD) (n=55) [25].
  • Summary:Hematological inherited diseases can be cured by hematopoietic stem cell transplantation (HSCT) from an human leukocyte antigen (HLA)-identical sibling donor (MSD), but the outcome of unrelated donors (URD) or haploidentical donors (HMD) has been a cause of concern [26].
  • SIGNIFICANCE AND IMPACT OF THE STUDY: This study demonstrates the utility of the MSD for studying the micro-ecology of the oral cavity [27].

Associations of MSD with chemical compounds

  • Significantly (P < or = 0.05) lower recovery of heat-stressed cells was observed on MSMA than on TSA, MEMB agar, or MSD agar [5].
  • We studied two groups of five healthy volunteers treated with 20 mg/day of pravastatin (Squibb, Italy) or simvastatin (MSD) for a month [28].
  • BACKGROUND: Montelukast (Singulair, MSD) has been shown to have a beneficial effect on the clinical symptoms of asthma [29].
  • A nonderivatization analytical method has been developed to analyze C6-C20 fatty acids and cis-pinonic acid on a GC/ FID and a GC/MSD using a polar DB-FFAP capillary column [30].
  • RESULTS: After segregation into three groups (baseline CETP<1.58, 1.58-2.21, >2.21 mg L(-1)), subjects with the highest CETP had significantly higher baseline total cholesterol, LDL-C and triglycerides (P<0.01), while HDL-C, MSD and MOD were not different among these groups [19].

Other interactions of MSD

  • This leads to the conclusion that the ineffective response to iron therapy in cases of ACD and MSD can be explained by a decline of transferrin receptors on the red cells [31].
  • Mutations in the SUMF1 gene cause MSD (multiple sulfatase deficiency), an autosomal recessive disease in which the activities of all sulfatases are profoundly reduced [32].
  • For example, MS-associated depression (MSD) was attributed to pathophysiological processes such as immune dysregulation and cerebral inflammation [33].
  • Differently from what was previously reported in Multiple sulfatase deficiency (MSD, OMIM 272200) is an autosomal recessive leukodystrophy associated with the deficiency of several, in total seven, sulfatases [34].
  • CKB analysis revealed considerable bacterial diversity within the respective MSD [27].

Analytical, diagnostic and therapeutic context of MSD

  • The instrumental analysis was performed by gas chromatography with mass spectrometric detection (GC-MSD) [35].
  • This study demonstrates that a hepatitis B vaccination schedule initiated with MSD rDNA vaccine can be completed with SB rDNA vaccine [36].
  • After completion of a 100% VO2max exercise test on a bicycle ergometer, which elicited exhaustion in 14.3 +/- 1.4 min (MSD), subjects were randomly assigned to exercise trials at 40% and 70% VO2max for 15 min, each of the three tests being separated by 7 d [37].
  • These findings suggest that the EBS may serve as an animal model for MSD [33].
  • For patients who lack a MSD there is a significant minority who fail immunosuppressive therapy or suffer from a severe constitutional aplastic anaemia in which immunosuppression would be ineffective [38].


  1. Equal IgG antibody response to pneumococcal vaccination in all stages of human immunodeficiency virus disease. Vandenbruaene, M., Colebunders, R., Mascart-Lemone, F., Haerden, Y., Van Hove, D., Peeters, M., Goeman, J., Van Royen, P., Avonts, D. J. Infect. Dis. (1995) [Pubmed]
  2. Coal tar phototoxicity: kinetics and exposure parameters. Diette, K.M., Gange, R.W., Stern, R.S., Arndt, K.A., Parrish, J.A. J. Invest. Dermatol. (1983) [Pubmed]
  3. Persistence of anti-HBs among health care personnel immunized with hepatitis B vaccine. Pasko, M.T., Beam, T.R. American journal of public health. (1990) [Pubmed]
  4. Serum 13C-bicarbonate in the assessment of gastric Helicobacter pylori urease activity. Moulton-Barrett, R., Triadafilopoulos, G., Michener, R., Gologorsky, D. Am. J. Gastroenterol. (1993) [Pubmed]
  5. Suitability of selective plating media for recovering heat- or freeze-stressed Escherichia coli O157:H7 from tryptic soy broth and ground beef. Rocelle, M., Clavero, S., Beuchat, L.R. Appl. Environ. Microbiol. (1995) [Pubmed]
  6. Fatigue in multiple sclerosis and its relationship to depression and neurologic disability. Bakshi, R., Shaikh, Z.A., Miletich, R.S., Czarnecki, D., Dmochowski, J., Henschel, K., Janardhan, V., Dubey, N., Kinkel, P.R. Mult. Scler. (2000) [Pubmed]
  7. Saudi variant of multiple sulfatase deficiency. al Aqeel, A., Ozand, P.T., Brismar, J., Gascon, G.G., Brismar, G., Nester, M., Sakati, N. J. Child Neurol. (1992) [Pubmed]
  8. Report on EFSD/MSD Travel Fellowship for Young Scientists 2001. % week stay at the MRC Phosphorylation Unit, University of Dundee. Göransson, O. Diabetologia (2002) [Pubmed]
  9. Angiotensin II AT1 receptor antagonism prevents detrimental renal actions of acute diuretic therapy in human heart failure. Chen, H.H., Redfield, M.M., Nordstrom, L.J., Cataliotti, A., Burnett, J.C. Am. J. Physiol. Renal Physiol. (2003) [Pubmed]
  10. Targeting of antihapten antibodies to activated T cells via an IL-2-hapten conjugate prolongs cardiac graft survival. Lussow, A.R., Fanget, L., Gao, L., Block, M., Buelow, R., Pouletty, P. Transplantation (1996) [Pubmed]
  11. Penetration of norfloxacin into the aqueous humor of the human eye. Huber-Spitzy, V.N., Czejka, M., Georgiew, L., Arocker-Mettinger, E., Grabner, G. Invest. Ophthalmol. Vis. Sci. (1992) [Pubmed]
  12. Evidence for percutaneous absorption of isotretinoin from the photo-isomerization of topical tretinoin. Lehman, P.A., Malany, A.M. J. Invest. Dermatol. (1989) [Pubmed]
  13. Acute cholangitis and pancreatitis associated with sulindac (clinoril). Lerche, A., Vyberg, M., Kirkegaard, E. Histopathology (1987) [Pubmed]
  14. Efficacy and safety of timolol/pilocarpine combination drops in glaucoma patients. Uusitalo, R.J., Palkama, A. Acta ophthalmologica. (1994) [Pubmed]
  15. Three days cefoxitin in perforated appendicitis. Lose, G., Holm, B., Bauer, T., Graversen, P., Kristensen, E.S., Larsen, E., Persson, M., Skjoldborg, H., Vennits, B. Annales chirurgiae et gynaecologiae. (1986) [Pubmed]
  16. Effect of Clinoril (sulindac, MSD), piroxicam and placebo on the hypotensive effect of propranolol in patients with mild to moderate essential hypertension. Ebel, D.L., Rhymer, A.R., Stahl, E., Tipping, R. Scand. J. Rheumatol. Suppl. (1986) [Pubmed]
  17. A comparison of lisinopril and atenolol in black and Indian patients with mild-to-moderate essential hypertension. Seedat, Y.K., Parag, K.B. S. Afr. Med. J. (1987) [Pubmed]
  18. Fluorotelomer alcohol biodegradation-direct evidence that perfluorinated carbon chains breakdown. Wang, N., Szostek, B., Buck, R.C., Folsom, P.W., Sulecki, L.M., Capka, V., Berti, W.R., Gannon, J.T. Environ. Sci. Technol. (2005) [Pubmed]
  19. Cholesteryl ester transfer protein concentration is associated with progression of atherosclerosis and response to pravastatin in men with coronary artery disease (REGRESS). Klerkx, A.H., de Grooth, G.J., Zwinderman, A.H., Jukema, J.W., Kuivenhoven, J.A., Kastelein, J.J. Eur. J. Clin. Invest. (2004) [Pubmed]
  20. Removal of biocide pentachlorophenol in water system by the spent mushroom compost of Pleurotus pulmonarius. Law, W.M., Lau, W.N., Lo, K.L., Wai, L.M., Chiu, S.W. Chemosphere (2003) [Pubmed]
  21. Exploratory study of general practitioners' orientations to general practice and responses to change. Petchey, R. The British journal of general practice : the journal of the Royal College of General Practitioners. (1994) [Pubmed]
  22. Depositing electron microscopy maps. Fuller, S.D. Structure (Camb.) (2003) [Pubmed]
  23. Chemical compositions of brain and myelin in two patients with multiple sulphatase deficiency (a variant form of metachromatic leukodystrophy). Eto, Y., Meier, C., Herschkowitz, N.N. J. Neurochem. (1976) [Pubmed]
  24. Unmanipulated bone marrow transplantation from one-HLA locus mismatched siblings carries high transplant-related mortality in Chinese patients. Leung, A.Y., Lie, A.K., Au, W.Y., Hawkins, B.R., Kwong, Y.L., Liang, R. Haematologica (2001) [Pubmed]
  25. Relationship between CsA trough blood concentration and severity of acute graft-versus-host disease after paediatric stem cell transplantation from matched-sibling or unrelated donors. Martin, P., Bleyzac, N., Souillet, G., Galambrun, C., Bertrand, Y., Maire, P.H., Jelliffe, R.W., Aulagner, G. Bone Marrow Transplant. (2003) [Pubmed]
  26. Impact of HLA matching on outcome of hematopoietic stem cell transplantation in children with inherited diseases: a single-center comparative analysis of genoidentical, haploidentical or unrelated donors. Caillat-Zucman, S., Le Deist, F., Haddad, E., Gannagé, M., Dal Cortivo, L., Jabado, N., Hacein-Bey-Abina, S., Blanche, S., Casanova, J.L., Fischer, A., Cavazzana-Calvo, M. Bone Marrow Transplant. (2004) [Pubmed]
  27. Development and characterization of a simple perfused oral microcosm. McBain, A.J., Sissons, C., Ledder, R.G., Sreenivasan, P.K., De Vizio, W., Gilbert, P. J. Appl. Microbiol. (2005) [Pubmed]
  28. Evidence of plasma CoQ10-lowering effect by HMG-CoA reductase inhibitors: a double-blind, placebo-controlled study. Ghirlanda, G., Oradei, A., Manto, A., Lippa, S., Uccioli, L., Caputo, S., Greco, A.V., Littarru, G.P. Journal of clinical pharmacology. (1993) [Pubmed]
  29. Treatment of asthmatic patients with a cysteinyl leukotriene receptor-1 antagonist montelukast (Singulair), decreases the eosinophil survival-enhancing activity produced by peripheral blood mononuclear leukocytes in vitro. Becler, K., Håkansson, L., Rak, S. Allergy (2002) [Pubmed]
  30. Nonderivatization analytical method of fatty acids and cis pinonic acid and its application in ambient PM2.5 aerosols in the greater Vancouver area in Canada. Cheng, Y., Li, S.M. Environ. Sci. Technol. (2005) [Pubmed]
  31. The expression of transferrin receptors on erythroblasts in anaemia of chronic disease, myelodysplastic syndromes and iron deficiency. Kuiper-Kramer, P.A., Huisman, C.M., Van der Molen-Sinke, J., Abbes, A., Van Eijk, H.G. Acta Haematol. (1997) [Pubmed]
  32. SUMF1 enhances sulfatase activities in vivo in five sulfatase deficiencies. Fraldi, A., Biffi, A., Lombardi, A., Visigalli, I., Pepe, S., Settembre, C., Nusco, E., Auricchio, A., Naldini, L., Ballabio, A., Cosma, M.P. Biochem. J. (2007) [Pubmed]
  33. Experimental autoimmune encephalomyelitis-associated behavioral syndrome as a model of 'depression due to multiple sclerosis'. Pollak, Y., Orion, E., Goshen, I., Ovadia, H., Yirmiya, R. Brain Behav. Immun. (2002) [Pubmed]
  34. Pitfalls in the diagnosis of multiple sulfatase deficiency. Mancini, G.M., van Diggelen, O.P., Huijmans, J.G., Stroink, H., de Coo, R.F. Neuropediatrics. (2001) [Pubmed]
  35. Selective extraction of benzoic acid from landfill leachate by solid-phase extraction and ion-exchange chromatography. do Nascimento Filho, I., Schossler, P., Santos Freitas, L., Melecchi, M.I., Rodrigues Vale, M.G., Bastos Caramão, E. Journal of chromatography. A. (2004) [Pubmed]
  36. Evaluation of initiating a hepatitis B vaccination schedule with one vaccine and completing it with another. Bush, L.M., Moonsammy, G.I., Boscia, J.A. Vaccine (1991) [Pubmed]
  37. Exercise intensity-related responses of fibrinolytic activity and vasopressin in man. el-Sayed, M.S. Medicine and science in sports and exercise. (1990) [Pubmed]
  38. Improved outcome of alternative donor bone marrow transplantation in children with severe aplastic anaemia using a conditioning regimen containing low-dose total body irradiation, cyclophosphamide and Campath. Vassiliou, G.S., Webb, D.K., Pamphilon, D., Knapper, S., Veys, P.A. Br. J. Haematol. (2001) [Pubmed]
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