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Chemical Compound Review

DEPTh     diethoxy-hydroxy- sulfanylidene-phosphorane

Synonyms: DETP, HMDB01460, DETP (ester), NSC-289403, NSC-289404, ...
 
 
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High impact information on diethoxy-hydroxy-thioxo-phosphorane

  • As the initial step in biomarker validation, this research determined background levels, detection limits, and stabilities of six organophosphate metabolites in meconium: diethylphosphate (DEP), diethylthiophosphate (DETP), diethyldithiophosphate (DEDTP), dimethylphosphate (DMP), dimethylthiophosphate (DMTP), and dimethyldithiophosphate (DMDTP) [1].
  • The primary oxidative pathway for PAR metabolism involved an initial hydrolysis to yield diethylthiophosphoric acid and p-nitrophenol [2].
  • No adverse DETP-related changes in pre- or post-shift neurobehavioral function were found with multiple linear regression models after adjusting for age, sex, education, and ethanol intake, although Symbol-Digit pairing speed was slower among the applicators as a group [3].
  • This method detected geometric mean values of the urinary DAPs in Japanese with and without occupational exposure to OPs, 16.6 or 27.4 for DMP, 1.0 or 0.7 for DEP, 1.3 or 2.3 for DMTP, and 1.0 or 1.1 microg/L for DETP, respectively [4].

References

  1. Measurement of organophosphate metabolites in postpartum meconium as a potential biomarker of prenatal exposure: a validation study. Whyatt, R.M., Barr, D.B. Environ. Health Perspect. (2001) [Pubmed]
  2. Pathways of microbial metabolism of parathion. Munnecke, D.M., Hsieh, D.P. Appl. Environ. Microbiol. (1976) [Pubmed]
  3. A behavioral evaluation of pest control workers with short-term, low-level exposure to the organophosphate diazinon. Maizlish, N., Schenker, M., Weisskopf, C., Seiber, J., Samuels, S. Am. J. Ind. Med. (1987) [Pubmed]
  4. Simultaneous determination of urinary dialkylphosphate metabolites of organophosphorus pesticides using gas chromatography-mass spectrometry. Ueyama, J., Saito, I., Kamijima, M., Nakajima, T., Gotoh, M., Suzuki, T., Shibata, E., Kondo, T., Takagi, K., Miyamoto, K., Takamatsu, J., Hasegawa, T., Takagi, K. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (2006) [Pubmed]
 
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