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Chemical Compound Review:

Glucotropeolin (2S,3R,4S,5S,6R)-2-(C-benzyl- N-sulfooxy...

Synonyms: AC1LCV37, C02153, 499-26-3, Glucotropaeolin, Benzyl glucosinolate

Kassie, F. et al., Kassie, F. et al., Müller, C. et al., Combourieu, B. et al., Cheng, D.L. et al.

Müller, Wittstock, Kassie, Laky, Gminski, Mersch-Sundermann, Scharf, Lhoste, Kansmüller,

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Disease relevance of Glucotropaeolin

In vitro digestion of sinigrin and glucotropaeolin by single strains of Bifidobacterium and identification of the digestive products [1].

High impact information on Glucotropaeolin

In addition, a moderate decrease in spontaneous DNA damage was seen in animals that received GT alone [2].
Identification of new derivatives of sinigrin and glucotropaeolin produced by the human digestive microflora using 1H NMR spectroscopy analysis of in vitro incubations [3].
Injection of glucotropaeolin into the hemolymph and ingestion of the same amount resulted in similar levels of intact glucosinolates recovered from larvae after different periods of time [4].
Contrary to the results with the juices, unexpected synergistic effects were observed with benzyl isothiocyanate (BITC, 0.6 microM), a breakdown product of glucotropaeolin contained abundantly in garden cress [5].

Analytical, diagnostic and therapeutic context of Glucotropaeolin

Conventional (NF), human flora associated (HFA) and germ free (GF) rats were treated either with 90 mg/kg IQ alone, 150 mg/kg GT alone or a combination of the two by gavage and DNA damage was determined in liver and colon cells using the alkaline single cell gel electrophoresis (SCGE) or comet assay [2].

References

In vitro digestion of sinigrin and glucotropaeolin by single strains of Bifidobacterium and identification of the digestive products. Cheng, D.L., Hashimoto, K., Uda, Y. Food Chem. Toxicol. (2004) [Pubmed]
Intestinal microflora plays a crucial role in the genotoxicity of the cooked food mutagen 2-amino-3-methylimidazo [4,5-f]quinoline. Kassie, F., Rabot, S., Kundi, M., Chabicovsky, M., Qin, H.M., Knasmüller, S. Carcinogenesis (2001) [Pubmed]
Identification of new derivatives of sinigrin and glucotropaeolin produced by the human digestive microflora using 1H NMR spectroscopy analysis of in vitro incubations. Combourieu, B., Elfoul, L., Delort, A.M., Rabot, S. Drug Metab. Dispos. (2001) [Pubmed]
Uptake and turn-over of glucosinolates sequestered in the sawfly Athalia rosae. Müller, C., Wittstock, U. Insect Biochem. Mol. Biol. (2005) [Pubmed]
Effects of garden and water cress juices and their constituents, benzyl and phenethyl isothiocyanates, towards benzo(a)pyrene-induced DNA damage: a model study with the single cell gel electrophoresis/Hep G2 assay. Kassie, F., Laky, B., Gminski, R., Mersch-Sundermann, V., Scharf, G., Lhoste, E., Kansmüller, S. Chem. Biol. Interact. (2003) [Pubmed]

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