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MeSH Review

Comet Assay

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Disease relevance of Comet Assay


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Biological context of Comet Assay


Anatomical context of Comet Assay


Associations of Comet Assay with chemical compounds


Gene context of Comet Assay


Analytical, diagnostic and therapeutic context of Comet Assay


  1. Beta-carotene enhances hydrogen peroxide-induced DNA damage in human hepatocellular HepG2 cells. Woods, J.A., Bilton, R.F., Young, A.J. FEBS Lett. (1999) [Pubmed]
  2. Comparison between the comet assay and pimonidazole binding for measuring tumour hypoxia. Olive, P.L., Durand, R.E., Raleigh, J.A., Luo, C., Aquino-Parsons, C. Br. J. Cancer (2000) [Pubmed]
  3. Detection of MNNG-induced DNA lesions in mammalian cells; validation of comet assay against DNA unwinding technique, alkaline elution of DNA and chromosomal aberrations. Slamenová, D., Gábelová, A., Ruzeková, L., Chalupa, I., Horváthová, E., Farkasová, T., Bozsakyová, E., Stĕtina, R. Mutat. Res. (1997) [Pubmed]
  4. Bleomycin-induced DNA damage and its removal in lymphocytes of breast cancer patients studied by comet assay. Jałoszyński, P., Kujawski, M., Czub-Swierczek, M., Markowska, J., Szyfter, K. Mutat. Res. (1997) [Pubmed]
  5. Modulation of DNA single-strand breaks by intracellular glutathione in human lung cells exposed to asbestos fibers. Puhakka, A., Ollikainen, T., Soini, Y., Kahlos, K., Säily, M., Koistinen, P., Pääkkö, P., Linnainmaa, K., Kinnula, V.L. Mutat. Res. (2002) [Pubmed]
  6. Functional proteomics of transforming growth factor-beta1-stimulated Mv1Lu epithelial cells: Rad51 as a target of TGFbeta1-dependent regulation of DNA repair. Kanamoto, T., Hellman, U., Heldin, C.H., Souchelnytskyi, S. EMBO J. (2002) [Pubmed]
  7. The FA/BRCA pathway is involved in melphalan-induced DNA interstrand cross-link repair and accounts for melphalan resistance in multiple myeloma cells. Chen, Q., Van der Sluis, P.C., Boulware, D., Hazlehurst, L.A., Dalton, W.S. Blood (2005) [Pubmed]
  8. Lack of poly(ADP-ribose) polymerase-1 gene product enhances cellular sensitivity to arsenite. Poonepalli, A., Balakrishnan, L., Khaw, A.K., Low, G.K., Jayapal, M., Bhattacharjee, R.N., Akira, S., Balajee, A.S., Hande, M.P. Cancer Res. (2005) [Pubmed]
  9. The bromodeoxyuridine comet assay: detection of maturation of recently replicated DNA in individual cells. McGlynn, A.P., Wasson, G., O'Connor, J., McKerr, G., McKelvey-Martin, V.J., Downes, C.S. Cancer Res. (1999) [Pubmed]
  10. Use of the comet assay to identify cells sensitive to tirapazamine in multicell spheroids and tumors in mice. Olive, P.L., Vikse, C.M., Banath, J.P. Cancer Res. (1996) [Pubmed]
  11. 2-Nitropropane-induced DNA damage in rat bone marrow. Deng, X.S., Tuo, J., Poulsen, H.E., Loft, S. Mutat. Res. (1997) [Pubmed]
  12. Anthocyanins protect against DNA damage induced by tert-butyl-hydroperoxide in rat smooth muscle and hepatoma cells. Lazzé, M.C., Pizzala, R., Savio, M., Stivala, L.A., Prosperi, E., Bianchi, L. Mutat. Res. (2003) [Pubmed]
  13. A single cell gel electrophoresis technique for the detection of DNA damage induced by ACNU, an alkylating agent or irradiation in murine glioma cell lines. Hara, A., Zhang, W., Kobayashi, H., Niikawa, S., Sakai, N., Yamada, H. Neurol. Res. (1994) [Pubmed]
  14. TNF-alpha induced DNA damage in primary murine hepatocytes. Wheelhouse, N.M., Chan, Y.S., Gillies, S.E., Caldwell, H., Ross, J.A., Harrison, D.J., Prost, S. Int. J. Mol. Med. (2003) [Pubmed]
  15. Caffeine modulates heat shock induced apoptosis in the human promyelocytic leukemia cell line HL-60. Poe, B.S., O'Neill, K.L. Cancer Lett. (1997) [Pubmed]
  16. Reduction of tumor hypoxia and inhibition of DNA repair by nicotinamide after irradiation of SCCVII murine tumors and normal tissues. Zheng, H., Olive, P.L. Cancer Res. (1996) [Pubmed]
  17. A2E-epoxides damage DNA in retinal pigment epithelial cells. Vitamin E and other antioxidants inhibit A2E-epoxide formation. Sparrow, J.R., Vollmer-Snarr, H.R., Zhou, J., Jang, Y.P., Jockusch, S., Itagaki, Y., Nakanishi, K. J. Biol. Chem. (2003) [Pubmed]
  18. TGFbeta1/Smad3 counteracts BRCA1-dependent repair of DNA damage. Dubrovska, A., Kanamoto, T., Lomnytska, M., Heldin, C.H., Volodko, N., Souchelnytskyi, S. Oncogene (2005) [Pubmed]
  19. The bacterial cytolethal distending toxin (CDT) triggers a G2 cell cycle checkpoint in mammalian cells without preliminary induction of DNA strand breaks. Sert, V., Cans, C., Tasca, C., Bret-Bennis, L., Oswald, E., Ducommun, B., De Rycke, J. Oncogene (1999) [Pubmed]
  20. Novel genotoxicity assays identify norethindrone to activate p53 and phosphorylate H2AX. Gallmeier, E., Winter, J.M., Cunningham, S.C., Kahn, S.R., Kern, S.E. Carcinogenesis (2005) [Pubmed]
  21. Repair of DNA interstrand crosslinks as a mechanism of clinical resistance to melphalan in multiple myeloma. Spanswick, V.J., Craddock, C., Sekhar, M., Mahendra, P., Shankaranarayana, P., Hughes, R.G., Hochhauser, D., Hartley, J.A. Blood (2002) [Pubmed]
  22. SIN-1-induced DNA damage in isolated human peripheral blood lymphocytes as assessed by single cell gel electrophoresis (comet assay). Doulias, P.T., Barbouti, A., Galaris, D., Ischiropoulos, H. Free Radic. Biol. Med. (2001) [Pubmed]
  23. Melanin protects melanocytes and keratinocytes against H2O2-induced DNA strand breaks through its ability to bind Ca2+. Hoogduijn, M.J., Cemeli, E., Ross, K., Anderson, D., Thody, A.J., Wood, J.M. Exp. Cell Res. (2004) [Pubmed]
  24. Activated IGF-1R inhibits hyperglycemia-induced DNA damage and promotes DNA repair by homologous recombination. Yang, S., Chintapalli, J., Sodagum, L., Baskin, S., Malhotra, A., Reiss, K., Meggs, L.G. Am. J. Physiol. Renal Physiol. (2005) [Pubmed]
  25. Deoxycholate induces DNA damage and apoptosis in human colon epithelial cells expressing either mutant or wild-type p53. Powolny, A., Xu, J., Loo, G. Int. J. Biochem. Cell Biol. (2001) [Pubmed]
  26. 5-aza-2'-deoxycytidine activates the p53/p21Waf1/Cip1 pathway to inhibit cell proliferation. Zhu, W.G., Hileman, T., Ke, Y., Wang, P., Lu, S., Duan, W., Dai, Z., Tong, T., Villalona-Calero, M.A., Plass, C., Otterson, G.A. J. Biol. Chem. (2004) [Pubmed]
  27. HIV-1 Tat increases cell survival in response to cisplatin by stimulating Rad51 gene expression. Chipitsyna, G., Slonina, D., Siddiqui, K., Peruzzi, F., Skorski, T., Reiss, K., Sawaya, B.E., Khalili, K., Amini, S. Oncogene (2004) [Pubmed]
  28. Modulation of exogenous and endogenous levels of thioredoxin in human skin fibroblasts prevents DNA damaging effect of ultraviolet A radiation. Didier, C., Pouget, J.P., Cadet, J., Favier, A., Béani, J.C., Richard, M.J. Free Radic. Biol. Med. (2001) [Pubmed]
  29. Effects of flavonoids and vitamin C on oxidative DNA damage to human lymphocytes. Noroozi, M., Angerson, W.J., Lean, M.E. Am. J. Clin. Nutr. (1998) [Pubmed]
  30. Mechanisms of cell sensitization to alpha radioimmunotherapy by doxorubicin or paclitaxel in multiple myeloma cell lines. Supiot, S., Gouard, S., Charrier, J., Apostolidis, C., Chatal, J.F., Barbet, J., Davodeau, F., Cherel, M. Clin. Cancer Res. (2005) [Pubmed]
  31. Expression of yeast apurinic/apyrimidinic endonuclease (APN1) protects lung epithelial cells from bleomycin toxicity. He, Y.H., Wu, M., Kobune, M., Xu, Y., Kelley, M.R., Martin, W.J. Am. J. Respir. Cell Mol. Biol. (2001) [Pubmed]
  32. Protamine 2 deficiency leads to sperm DNA damage and embryo death in mice. Cho, C., Jung-Ha, H., Willis, W.D., Goulding, E.H., Stein, P., Xu, Z., Schultz, R.M., Hecht, N.B., Eddy, E.M. Biol. Reprod. (2003) [Pubmed]
  33. Differential responses of EGFR-/AGT-expressing cells to the "combi-triazene" SMA41. Matheson, S.L., McNamee, J.P., Jean-Claude, B.J. Cancer Chemother. Pharmacol. (2003) [Pubmed]
  34. Mutagen sensitivity of peripheral blood from women carrying a BRCA1 or BRCA2 mutation. Trenz, K., Rothfuss, A., Schütz, P., Speit, G. Mutat. Res. (2002) [Pubmed]
  35. ABL-fusion oncoproteins activate multi-pathway of DNA repair: role in drug resistance? Majsterek, I., Slupianek, A., Hoser, G., Skórski, T., Blasiak, J. Biochimie (2004) [Pubmed]
  36. Analysis of 8-oxo-7,8-dihydro-2'-deoxyguanosine and DNA strand breaks in white blood cells of occupationally exposed workers: comparison with ambient monitoring, urinary metabolites and enzyme polymorphisms. Marczynski, B., Rihs, H.P., Rossbach, B., Hölzer, J., Angerer, J., Scherenberg, M., Hoffmann, G., Brüning, T., Wilhelm, M. Carcinogenesis (2002) [Pubmed]
  37. Inhibition of cell signaling by the combi-nitrosourea FD137 in the androgen independent DU145 prostate cancer cell line. Qiu, Q., Dudouit, F., Banerjee, R., McNamee, J.P., Jean-Claude, B.J. Prostate (2004) [Pubmed]
  38. Application of Euglena gracilis cells to comet assay: evaluation of DNA damage and repair. Aoyama, K., Iwahori, K., Miyata, N. Mutat. Res. (2003) [Pubmed]
  39. Early detection of staurosporine-induced apoptosis by comet and annexin V assays. Godard, T., Deslandes, E., Lebailly, P., Vigreux, C., Sichel, F., Poul, J.M., Gauduchon, P. Histochem. Cell Biol. (1999) [Pubmed]
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