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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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High impact information on Brassicaceae

  • For the Brassicaceae type, the gene controlling male function, SCR/SP11, and the gene controlling female function, SRK, have been identified [1].
  • To further understand CRC regulation in Arabidopsis thaliana, we performed phylogenetic footprinting analyses of 5' upstream regions of CRC orthologs from three Brassicaceae species, including Arabidopsis [2].
  • In addition, these putative BLR binding motifs were shown to be conserved in 17 of the 29 Brassicaceae species by phylogenetic footprinting [3].
  • Although there is little obvious sequence similarity outside the Brassicaceae, the intron from cucumber AG has at least partial activity in A. thaliana [4].
  • The major quantitative trait locus (QTL) affecting nitrile versus isothiocyanate formation was found very close to a gene encoding a homolog of a Brassica napus epithiospecifier protein (ESP), which causes the formation of epithionitriles instead of isothiocyanates during glucosinolate hydrolysis in the seeds of certain Brassicaceae [5].

Biological context of Brassicaceae

  • The evolution of the alcohol dehydrogenase gene family by loss of introns in plants of the genus Leavenworthia (Brassicaceae) [6].
  • Using these new sequences and five published sequences from GenBank, we constructed a phylogenetic tree of the Brassicaceae species under study and showed that the rate of nucleotide substitution in the first intron of nad4 is very low, about 0.16-0.23 x 10(-9) substitution per site per year, which is about half of the silent rate in exons of nad4 [7].
  • Recent data have revealed that the thale cress (Arabidopsis thaliana) contains a protein related to the p60 catalytic subunit of animal katanin, a microtubule-severing protein [8].
  • These data indicate that plasma alpha-carotene, beta-carotene, and lutein may be useful biomarkers of carotenoid-rich food intake and that lutein may act as an intake biomarker of commonly consumed vegetables in the Cruciferae family [9].
  • We report the potential phylogenetic utility of DNA sequence data from the last 700 bp of a ca. 1-kb intron of the MADS-box gene pistillata from a sampling of Sphaerocardamum species and other Brassicaceae [10].

Anatomical context of Brassicaceae

  • Treatment of cress (Lepidium sativum L.) roots with phytohormones (4.3 x 10(-5) M gibberellic acid plus 4.3 x 10(-5) M kinetin, 30 h; T.H. Iversen, 1969, Physiol. Plant. 22, 1251-1262) caused not only complete destarching of amyloplasts but also destruction of the polar arrangement of cell organelles in statocytes [11].
  • Growth stimulation of ectomycorrhizal fungi by root exudates of Brassicaceae plants: role of degraded compounds of indole glucosinolates [12].

Associations of Brassicaceae with chemical compounds


Gene context of Brassicaceae

  • Phylogenetic utility of the nuclear gene arginine decarboxylase: an example from Brassicaceae [18].
  • Here we provide genetic and molecular evidence for a role of ZEITLUPE (ZTL) in the targeted degradation of TIMING OF CAB EXPRESSION 1 (TOC1) in Arabidopsis thaliana (thale cress) [19].
  • Among the four known nitrilases of Arabidopsis thaliana, the isoform NIT4 is the most divergent one, and homologs of NIT4 are also known from species not belonging to the Brassicaceae like Nicotiana tabacum and Oryza sativa [20].
  • Differential targeting of GSH1 and GSH2 is achieved by multiple transcription initiation: implications for the compartmentation of glutathione biosynthesis in the Brassicaceae [21].
  • The indolo[2,1- b]quinazoline alkaloid tryptanthrin has previously been identified as the cyclooxygenase-2 (COX-2) inhibitory principle in the extract ZE550 prepared from the medicinal plant Isatis tinctoria (Brassicaceae) [22].

Analytical, diagnostic and therapeutic context of Brassicaceae

  • Sequence analyses suggested that the RPW8 gene family in Brassicaceae originated from an HR3-like ancestor gene through a series of duplications and that RPW8.1 and RPW8.2 evolved from functional diversification through positive selection several MYA [23].
  • Indole-3-carbinol (I3C), a naturally occurring component of broccoli, cabbage, and other members of the family Cruciferae, is a tumor modulator in several animal models that demonstrates significant chemoprevention against development of both spontaneous and chemically induced cancers while conversely eliciting tumor promoter effects in others [24].
  • Antibodies (CRA) showed specific labelings on Western immunoblots against a 43,000 dalton protein of the cress root crude extract [25].


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  2. Activation of CRABS CLAW in the Nectaries and Carpels of Arabidopsis. Lee, J.Y., Baum, S.F., Alvarez, J., Patel, A., Chitwood, D.H., Bowman, J.L. Plant Cell (2005) [Pubmed]
  3. Repression of AGAMOUS by BELLRINGER in floral and inflorescence meristems. Bao, X., Franks, R.G., Levin, J.Z., Liu, Z. Plant Cell (2004) [Pubmed]
  4. Regulatory elements of the floral homeotic gene AGAMOUS identified by phylogenetic footprinting and shadowing. Hong, R.L., Hamaguchi, L., Busch, M.A., Weigel, D. Plant Cell (2003) [Pubmed]
  5. The Arabidopsis epithiospecifier protein promotes the hydrolysis of glucosinolates to nitriles and influences Trichoplusia ni herbivory. Lambrix, V., Reichelt, M., Mitchell-Olds, T., Kliebenstein, D.J., Gershenzon, J. Plant Cell (2001) [Pubmed]
  6. The evolution of the alcohol dehydrogenase gene family by loss of introns in plants of the genus Leavenworthia (Brassicaceae). Charlesworth, D., Liu, F.L., Zhang, L. Mol. Biol. Evol. (1998) [Pubmed]
  7. Rates of nucleotide substitution in angiosperm mitochondrial DNA sequences and dates of divergence between Brassica and other angiosperm lineages. Yang, Y.W., Lai, K.N., Tai, P.Y., Li, W.H. J. Mol. Evol. (1999) [Pubmed]
  8. Functional evidence for in vitro microtubule severing by the plant katanin homologue. Stoppin-Mellet, V., Gaillard, J., Vantard, M. Biochem. J. (2002) [Pubmed]
  9. Plasma carotenoids as biomarkers of vegetable intake: the University of Minnesota Cancer Prevention Research Unit Feeding Studies. Martini, M.C., Campbell, D.R., Gross, M.D., Grandits, G.A., Potter, J.D., Slavin, J.L. Cancer Epidemiol. Biomarkers Prev. (1995) [Pubmed]
  10. Potential phylogenetic utility of the low-copy nuclear gene pistillata in dicotyledonous plants: comparison to nrDNA ITS and trnL intron in Sphaerocardamum and other Brassicaceae. Bailey, C.D., Doyle, J.J. Mol. Phylogenet. Evol. (1999) [Pubmed]
  11. Hormone treatment of roots causes not only a reversible loss of starch but also of structural polarity in statocytes. Busch, M.B., Sievers, A. Planta (1990) [Pubmed]
  12. Growth stimulation of ectomycorrhizal fungi by root exudates of Brassicaceae plants: role of degraded compounds of indole glucosinolates. Zeng, R.S., Mallik, A.U., Setliff, E. J. Chem. Ecol. (2003) [Pubmed]
  13. Arabidopsis thaliana auxotrophs reveal a tryptophan-independent biosynthetic pathway for indole-3-acetic acid. Normanly, J., Cohen, J.D., Fink, G.R. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  14. Nitrilase in biosynthesis of the plant hormone indole-3-acetic acid from indole-3-acetonitrile: cloning of the Alcaligenes gene and site-directed mutagenesis of cysteine residues. Kobayashi, M., Izui, H., Nagasawa, T., Yamada, H. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  15. Identification of glucosyltransferase genes involved in sinapate metabolism and lignin synthesis in Arabidopsis. Lim, E.K., Li, Y., Parr, A., Jackson, R., Ashford, D.A., Bowles, D.J. J. Biol. Chem. (2001) [Pubmed]
  16. Studies on NADH (NADPH)-cytochrome c reductase (FMN-containing) from yeast. Isolation and physicochemical properties of the enzyme from top-fermenting ale yeast. Johnson, M.S., Kuby, S.A. J. Biol. Chem. (1985) [Pubmed]
  17. 1. The chemistry and pharmacology of indole-3-carbinol (indole-3-methanol) and 3-(methoxymethyl)indole. [Part II]. Broadbent, T.A., Broadbent, H.S. Current medicinal chemistry. (1998) [Pubmed]
  18. Phylogenetic utility of the nuclear gene arginine decarboxylase: an example from Brassicaceae. Galloway, G.L., Malmberg, R.L., Price, R.A. Mol. Biol. Evol. (1998) [Pubmed]
  19. Targeted degradation of TOC1 by ZTL modulates circadian function in Arabidopsis thaliana. Más, P., Kim, W.Y., Somers, D.E., Kay, S.A. Nature (2003) [Pubmed]
  20. The Arabidopsis thaliana isogene NIT4 and its orthologs in tobacco encode beta-cyano-L-alanine hydratase/nitrilase. Piotrowski, M., Schönfelder, S., Weiler, E.W. J. Biol. Chem. (2001) [Pubmed]
  21. Differential targeting of GSH1 and GSH2 is achieved by multiple transcription initiation: implications for the compartmentation of glutathione biosynthesis in the Brassicaceae. Wachter, A., Wolf, S., Steininger, H., Bogs, J., Rausch, T. Plant J. (2005) [Pubmed]
  22. Inhibitory activity of tryptanthrin on prostaglandin and leukotriene synthesis. Danz, H., Stoyanova, S., Thomet, O.A., Simon, H.U., Dannhardt, G., Ulbrich, H., Hamburger, M. Planta Med. (2002) [Pubmed]
  23. Origin and maintenance of a broad-spectrum disease resistance locus in Arabidopsis. Xiao, S., Emerson, B., Ratanasut, K., Patrick, E., O'Neill, C., Bancroft, I., Turner, J.G. Mol. Biol. Evol. (2004) [Pubmed]
  24. Transplacental exposure to indole-3-carbinol induces sex-specific expression of CYP1A1 and CYP1B1 in the liver of Fischer 344 neonatal rats. Larsen-Su, S.A., Williams, D.E. Toxicol. Sci. (2001) [Pubmed]
  25. Monoclonal antibody CRA against a fraction of actin from cress roots recognizes its antigen in different plant species. Koropp, K., Volkmann, D. Eur. J. Cell Biol. (1994) [Pubmed]
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