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Chemical Compound Review:

Tonite 1-chloropropan-2-one

Synonyms: Chloracetone, Chloroacetone, A-Stoff, CCRIS 1943, AG-H-16495, ...

Le Curieux, F. et al., Hussain, S. et al., Connor, D.T. et al., Hollaway, M.R. et al.

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Disease relevance of Acetonyl chloride

Chloroacetone as an active-site-directed inhibitor of the aliphatic amidase from Pseudomonas aeruginosa [1].
In the SOS chromotest, all the compounds except monochloropropanone were found to induce primary DNA damage in Escherichia coli [2].

High impact information on Acetonyl chloride

Alkylation with aminoalkyl halides, or with 1-chloro-2-propanone followed by reductive amination, yielded the 3-substituted target compounds [3].
Three short-term assays (the SOS chromotest, the Ames-fluctuation test and the newt micronucleus test) were carried out to evaluate the genotoxicity of five chlorinated propanones identified in several chlorinated waters (monochloropropanone, 1,1-dichloropropanone, 1,3-dichloropropanone, 1,1,1-trichloropropanone and 1,1,3-trichloropropanone) [2].
Dose-response relationships for mutations induced in E. coli by some model compounds. With an addendum: Reaction kinetics in water of chloroethylene oxide, chloroacetaldehyde, and chloroacetone [4].

References

Chloroacetone as an active-site-directed inhibitor of the aliphatic amidase from Pseudomonas aeruginosa. Hollaway, M.R., Clarke, P.H., Ticho, T. Biochem. J. (1980) [Pubmed]
Study of the genotoxic activity of five chlorinated propanones using the SOS chromotest, the Ames-fluctuation test and the newt micronucleus test. Le Curieux, F., Marzin, D., Erb, F. Mutat. Res. (1994) [Pubmed]
3-(aminoalkyl)-1,2,3,4-tetrahydro-5H-[1]benzopyrano[3,4-c] pyridin-5-ones as potential anticholinergic bronchodilators. Connor, D.T., Unangst, P.C., Schwender, C.F., Sorenson, R.J., Carethers, M.E., Puchalski, C., Brown, R.E., Finkel, M.P. J. Med. Chem. (1989) [Pubmed]
Dose-response relationships for mutations induced in E. coli by some model compounds. With an addendum: Reaction kinetics in water of chloroethylene oxide, chloroacetaldehyde, and chloroacetone. Hussain, S., Osterman-Golkar, S. Hereditas (1984) [Pubmed]

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