Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

dioxydiquinone 2,3-dihydroxycyclohex-2-ene- 1,4,5,6-tetrone

Synonyms: SureCN916303, NSC624150, AR-1L3117, AKOS006228674, AC1L26QK, ...

Murakami, K. et al.

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High impact information on RH

Addition of catalase protected DNA from the rhodizonic acid-mediated strand scission, indicating that hydroxyl radical may participate in the DNA damage [1].
Addition of rhodizonic acid with ferrous ion caused an inactivation of aconitase the most sensitive enzyme to oxidative stress in permeabilized yeast cells [1].
Rhodizonic acid further acted as a prooxidant causing a copper-dependent DNA damage [1].
Treatment of DNA from plasmid pBR322 and calf thymus with rhodizonic acid plus copper caused strand scission and the formation of 8-hydroxy-2'-deoxyguanosine in DNA [1].

References

Prooxidant action of rhodizonic acid: transition metal-dependent generation of reactive oxygen species causing the formation of 8-hydroxy-2'-deoxyguanosine formation in DNA. Murakami, K., Haneda, M., Naruse, M., Yoshino, M. Toxicology in vitro : an international journal published in association with BIBRA. (2006) [Pubmed]

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