High impact information on Synkamin

• Incubation of cells with catalase or treatment of the albumin fraction with isoniazid abolished the stimulation of glucose uptake by polyamines but did not alter the stimulatory effects of insulin or vitamin K5 [1].
• Fat cells treated with dithio(bis)nitrobenzoic acid completely regained the ability to respond to insulin or vitamin K5 after removal of the agent by washing in low concentrations of reductant [2].
• In vitro and in vivo antitumor effects of vitamin K5 on hepatocellular carcinoma [3].
• In the present study, we examined the antitumor effects of vitamin K5 on PLC/PRF/5 human hepatocellular carcinoma (HCC) cells in vitro and in vivo [3].
• Although a number of studies have shown that vitamins K1, K2 and K3 exerted antitumor effects on various types of rodent- and human-derived neoplastic cell lines, it has not been examined whether or not vitamin K5 also possesses antitumor activity [3].

Biological context of Synkamin

• By a flow cytometric analysis, it was shown that although vitamin K5 did not induce apoptosis on PLC/PRF/5 cells, it did induce G1 arrest on PLC/PRF/5 cells [3].
• Taken collectively, vitamin K5 could induce potent antitumor effects on HCC not only in vitro but also in vivo, at least in part by inducing G1 arrest of cell cycle through downregulation of Cdk4 expression [3].

References