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Chemical Compound Review

Fluoropyruvate     3-fluoro-2-oxo-propanoic acid

Synonyms: CHEMBL1162543, CHEBI:55521, NSC-21734, AC1Q4OPL, NSC21734, ...
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Disease relevance of Fluoropyruvic acid


High impact information on Fluoropyruvic acid

  • Both (Z)- and (E)-F-PEP partition between carboxylation to produce 3-fluorooxalacetate and hydrolysis to produce 3-fluoropyruvate [2].
  • The pyruvate dehydrogenase complex (PDH complex) of Escherichia coli and its pyruvate dehydrogenase component (E1) are rapidly inactivated by low concentrations of fluoropyruvate in a thiamin pyrophosphate (TPP) dependent process [1].
  • Fluoropyruvate is known to generate acetyl-TPP at the active site of E1 [1].
  • Transcarboxylase, coupled to malate dehydrogenase, has been used to analyze samples of chiral fluoropyruvate obtained by dephosphorylation of (Z)-fluorophosphoenolpyruvate in D2O in the presence of either pyruvate kinase or enzyme I from the Escherichia coli sugar transport systems [3].
  • Thiomethylated lactate dehydrogenase was able to form an abortive adduct between NAD+ and fluoropyruvate [4].

Biological context of Fluoropyruvic acid

  • After 3 days, 10-36% of the colonies showed RFLPs, but the type was now dominated by the fluoropyruvate-specific RFLP, which, at higher resolution, invariably proved to be heterogeneous [5].

Associations of Fluoropyruvic acid with other chemical compounds


Gene context of Fluoropyruvic acid


  1. Inactivation of the pyruvate dehydrogenase complex of Escherichia coli by fluoropyruvate. Flournoy, D.S., Frey, P.A. Biochemistry (1989) [Pubmed]
  2. Mechanistic studies of phosphoenolpyruvate carboxylase from Zea mays with (Z)- and (E)-3-fluorophosphoenolpyruvate as substrates. Janc, J.W., Urbauer, J.L., O'Leary, M.H., Cleland, W.W. Biochemistry (1992) [Pubmed]
  3. Fluorine NMR studies on stereochemical aspects of reactions catalyzed by transcarboxylase, pyruvate kinase, and enzyme I. Hoving, H., Crysell, B., Leadlay, P.F. Biochemistry (1985) [Pubmed]
  4. A detailed investigation of the properties of lactate dehydrogenase in which the 'Essential' cysteine-165 is modified by thioalkylation. Bloxham, D.P., Sharma, R.P., Wilton, D.C. Biochem. J. (1979) [Pubmed]
  5. Inhibitor-associated transposition events in Corynebacterium glutamicum. Garbe, T.R., Suzuki, N., Inui, M., Yukawa, H. Mol. Genet. Genomics (2004) [Pubmed]
  6. Pyruvate dehydrogenase component of the pyruvate dehydrogenase complex from Escherichia coli K12. Purification and characterization. Saumweber, H., Binder, R., Bisswanger, H. Eur. J. Biochem. (1981) [Pubmed]
  7. Oxidative and defluorinative metabolism of fludalanine, 2-2H-3-fluoro-D-alanine. Darland, G.K., Hajdu, R., Kropp, H., Kahan, F.M., Walker, R.W., Vandenheuvel, W.J. Drug Metab. Dispos. (1986) [Pubmed]
  8. Inactivation of flavocytochrome b2 with fluoropyruvate. Reaction at the active-site histidine. Urban, P., Lederer, F. Eur. J. Biochem. (1988) [Pubmed]
  9. Tools for discovery of inhibitors of the 1-deoxy-D-xylulose 5-phosphate (DXP) synthase and DXP reductoisomerase: an approach with enzymes from the pathogenic bacterium Pseudomonas aeruginosa. Altincicek, B., Hintz, M., Sanderbrand, S., Wiesner, J., Beck, E., Jomaa, H. FEMS Microbiol. Lett. (2000) [Pubmed]
  10. Transport of pyruvate in Saccharomyces cerevisiae and cloning of the gene encoded pyruvate permease. Akita, O., Nishimori, C., Shimamoto, T., Fujii, T., Iefuji, H. Biosci. Biotechnol. Biochem. (2000) [Pubmed]
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