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Chemical Compound Review:

GTP [[[(2R,3S,4R,5R)-5-(2-amino- 6-oxo-3H-purin...

Synonyms: H4gtp, CHEBI:15996, HMDB01273, AC1L1NEA, AC1Q1IDH, ...

Aramaki, T. et al., Panka, D. et al., Tutas, D.J. et al., Deviller, P. et al., Panka, D. et al.

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Disease relevance of GUANOSINE TRIPHOSPHATE

The [alpha-32P]3'-azido-3'-deoxyxylofuranosyl analogues of 5'-ATP and 5'-GTP were used as photoaffinity probes to derivatize two distinctly different active sites of the DNA-dependent RNA polymerase obtained from Escherichia coli [1].

High impact information on GUANOSINE TRIPHOSPHATE

RNA polymerase. Synthesis and kinetic inhibition by 9-(3'-azido-3'-deoxy-beta-D-xylofuranosyl) derivatives of 5'-ATP and 5'-GTP [2].
4. The enzyme acts upon 5'-ATP- and 5'-GTP-terminated RNA and also on 5'-ATP-terminated poly(A), catalyzing the hydrolysis of only the gamma-phosphate [3].
An enzyme, guanyl cyclase, which catalyzes formation of CYCLIC 3',5'-GMP from 5'-GTP, has been identified in human peripheral lymphocytes [4].

Analytical, diagnostic and therapeutic context of GUANOSINE TRIPHOSPHATE

Photoaffinity labeling with the use of 32P P3-(4-azidoanilido)-P1 5'-GTP followed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and autoradiography revealed the incorporation of radioactivity into molecular mass of the 43 kDa and 33-34 kDa proteins [5].

References

RNA polymerase. Direct evidence for two active sites involved in transcription. Panka, D., Dennis, D. J. Biol. Chem. (1985) [Pubmed]
RNA polymerase. Synthesis and kinetic inhibition by 9-(3'-azido-3'-deoxy-beta-D-xylofuranosyl) derivatives of 5'-ATP and 5'-GTP. Panka, D., Dennis, D. J. Biol. Chem. (1984) [Pubmed]
Purification and characterization of core-associated polynucleotide 5'-triphosphatase from Vaccinia virus. Tutas, D.J., Paoletti, E. J. Biol. Chem. (1977) [Pubmed]
Guanyl cyclase activity of human blood lymphocytes. Deviller, P., Cille, Y., Betuel, H. Enzyme (1975) [Pubmed]
(D-Ala, D-Leu) enkephalin reduces the binding of GTP in hippocampal membranes. Aramaki, T., Saito, K., Shinno, E., Ohnishi, T., Ooi, Y., Maeda, S., Inoki, R. Life Sci. (1993) [Pubmed]

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