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Chemical Compound Review

cyclic gmp     2-amino-9-[(1S,6R,8R,9R)-3,9- dihydroxy-3...

Synonyms: cGMP, cyclic-GMP, SureCN738, CHEMBL395336, AG-J-03245, ...
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Disease relevance of cyclic gmp


Psychiatry related information on cyclic gmp

  • Erectile dysfunction in cyclic GMP-dependent kinase I-deficient mice [6].
  • Both EGTA and saturating doses of cyclic GMP block the light response, but only cyclic GMP increases response latency, which suggests that if calcium is involved in transduction, it is controlled by the hydrolysis of cyclic GMP [7].
  • The number of gene pairs which regulate the effect of morphine on motor activity was assumed to be more than one; however, the contribution of more than one segregating unit in the effect of morphine on plasma cyclic GMP was not demonstrated [8].
  • In this study, we investigated the involvement of the interaction between sigma receptors and the nitric oxide/cyclic GMP pathway in short term memory in mice, assessed through spontaneous alternation behavior in a Y-maze [9].
  • Here we report on the effect of post-training intrahippocampal infusion of membrane-permeable analogues of these cyclic nucleotides on the consolidation of inhibitory avoidance learning in rats and on the effect of this task on hippocampal cGMP and cAMP levels [10].

High impact information on cyclic gmp


Chemical compound and disease context of cyclic gmp


Biological context of cyclic gmp


Anatomical context of cyclic gmp


Associations of cyclic gmp with other chemical compounds


Gene context of cyclic gmp


Analytical, diagnostic and therapeutic context of cyclic gmp

  • Levels of cyclic AMP (cAMP) and cyclic GMP (cGMP) in these tumors were measured by radioimmunoassay [43].
  • SIN-1 increased cyclic GMP, and with greater effect on LVH; however, this resulted in a decrement in function only in the control group [44].
  • After an initial peak at 1 h after hypophysectomy, adrenal cyclic GMP declined to baseline at 4-12 h but thereafter progressively rose with time, eventually reaching levels over 1 pmol per mg tissue [45].
  • Rat ANP(5-25) was weaker than human ANP(1-28) at inhibiting ir-endothelin-1 secretion and increasing cyclic GMP in the cells. ir-Endothelin-1 in the medium consisted of two components separated by high pressure liquid chromatography; the major one corresponded to endothelin-1(1-21) and the minor one corresponded to big endothelin-1(1-38) [46].
  • Here, we use "patch-cramming," in which an excised, inside-out membrane patch containing cyclic nucleotide-gated ion channels is used as a biosensor, to obtain the first real-time measurements of cGMP in intact cells [47].


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  28. Cyclic GMP can increase rod outer-segment light-sensitive current 10-fold without delay of excitation. Cobbs, W.H., Pugh, E.N. Nature (1985) [Pubmed]
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  30. Sodium nitroprusside and other smooth muscle-relaxants increase cyclic GMP levels in rat ductus deferens. Schultz, K., Schultz, K., Schultz, G. Nature (1977) [Pubmed]
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  47. Real-time patch-cram detection of intracellular cGMP reveals long-term suppression of responses to NO and muscarinic agonists. Trivedi, B., Kramer, R.H. Neuron (1998) [Pubmed]
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