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Chemical Compound Review

cyclic gmp     2-amino-9-[(1S,6R,8R,9R)-3,9- dihydroxy-3...

Synonyms: cGMP, cyclic-GMP, SureCN738, CHEMBL395336, AG-J-03245, ...
 
 
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Disease relevance of cyclic gmp

 

Psychiatry related information on cyclic gmp

  • Erectile dysfunction in cyclic GMP-dependent kinase I-deficient mice [6].
  • Both EGTA and saturating doses of cyclic GMP block the light response, but only cyclic GMP increases response latency, which suggests that if calcium is involved in transduction, it is controlled by the hydrolysis of cyclic GMP [7].
  • The number of gene pairs which regulate the effect of morphine on motor activity was assumed to be more than one; however, the contribution of more than one segregating unit in the effect of morphine on plasma cyclic GMP was not demonstrated [8].
  • In this study, we investigated the involvement of the interaction between sigma receptors and the nitric oxide/cyclic GMP pathway in short term memory in mice, assessed through spontaneous alternation behavior in a Y-maze [9].
  • Here we report on the effect of post-training intrahippocampal infusion of membrane-permeable analogues of these cyclic nucleotides on the consolidation of inhibitory avoidance learning in rats and on the effect of this task on hippocampal cGMP and cAMP levels [10].
 

High impact information on cyclic gmp

 

Chemical compound and disease context of cyclic gmp

 

Biological context of cyclic gmp

 

Anatomical context of cyclic gmp

 

Associations of cyclic gmp with other chemical compounds

 

Gene context of cyclic gmp

 

Analytical, diagnostic and therapeutic context of cyclic gmp

  • Levels of cyclic AMP (cAMP) and cyclic GMP (cGMP) in these tumors were measured by radioimmunoassay [43].
  • SIN-1 increased cyclic GMP, and with greater effect on LVH; however, this resulted in a decrement in function only in the control group [44].
  • After an initial peak at 1 h after hypophysectomy, adrenal cyclic GMP declined to baseline at 4-12 h but thereafter progressively rose with time, eventually reaching levels over 1 pmol per mg tissue [45].
  • Rat ANP(5-25) was weaker than human ANP(1-28) at inhibiting ir-endothelin-1 secretion and increasing cyclic GMP in the cells. ir-Endothelin-1 in the medium consisted of two components separated by high pressure liquid chromatography; the major one corresponded to endothelin-1(1-21) and the minor one corresponded to big endothelin-1(1-38) [46].
  • Here, we use "patch-cramming," in which an excised, inside-out membrane patch containing cyclic nucleotide-gated ion channels is used as a biosensor, to obtain the first real-time measurements of cGMP in intact cells [47].

References

  1. Guanylyl cyclase is a heat-stable enterotoxin receptor. Schulz, S., Green, C.K., Yuen, P.S., Garbers, D.L. Cell (1990) [Pubmed]
  2. Antipsychotics block muscarinic acetylcholine receptor-mediated cyclic GMP formation in cultured mouse neuroblastoma cells. Richelson, E. Nature (1977) [Pubmed]
  3. Morphine elevates levels of cyclic GMP in a neuroblastoma X glioma hybrid cell line. Gullis, R., Traber, J., Hamprecht, B. Nature (1975) [Pubmed]
  4. Involvement of cyclic GMP phosphodiesterase activator in an hereditary retinal degeneration. Liu, Y.P., Krishna, G., Aguirre, G., Chader, G.J. Nature (1979) [Pubmed]
  5. Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy. Takimoto, E., Champion, H.C., Li, M., Belardi, D., Ren, S., Rodriguez, E.R., Bedja, D., Gabrielson, K.L., Wang, Y., Kass, D.A. Nat. Med. (2005) [Pubmed]
  6. Erectile dysfunction in cyclic GMP-dependent kinase I-deficient mice. Hedlund, P., Aszodi, A., Pfeifer, A., Alm, P., Hofmann, F., Ahmad, M., Fassler, R., Andersson, K.E. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  7. Physiological evidence that light-mediated decrease in cyclic GMP is an intermediary process in retinal rod transduction. Miller, W.H. J. Gen. Physiol. (1982) [Pubmed]
  8. Genetic analysis of the effects of morphine on plasma cyclic nucleotides and locomotor activity in male mice. Muraki, T., Kato, R. Psychopharmacology (Berl.) (1985) [Pubmed]
  9. Effects of sigma receptor agonists on the impairment of spontaneous alternation behavior and decrease of cyclic GMP level induced by nitric oxide synthase inhibitors in mice. Mamiya, T., Noda, Y., Noda, A., Hiramatsu, M., Karasawa, K., Kameyama, T., Furukawa, S., Yamada, K., Nabeshima, T. Neuropharmacology (2000) [Pubmed]
  10. Hippocampal cGMP and cAMP are differentially involved in memory processing of inhibitory avoidance learning. Bernabeu, R., Schmitz, P., Faillace, M.P., Izquierdo, I., Medina, J.H. Neuroreport (1996) [Pubmed]
  11. The molecular basis of hypertension. Garbers, D.L., Dubois, S.K. Annu. Rev. Biochem. (1999) [Pubmed]
  12. Oral sildenafil in the treatment of erectile dysfunction. Sildenafil Study Group. Goldstein, I., Lue, T.F., Padma-Nathan, H., Rosen, R.C., Steers, W.D., Wicker, P.A. N. Engl. J. Med. (1998) [Pubmed]
  13. Cyclic GMP and calcium mediate phytochrome phototransduction. Bowler, C., Neuhaus, G., Yamagata, H., Chua, N.H. Cell (1994) [Pubmed]
  14. The primary structure of a plasma membrane guanylate cyclase demonstrates diversity within this new receptor family. Schulz, S., Singh, S., Bellet, R.A., Singh, G., Tubb, D.J., Chin, H., Garbers, D.L. Cell (1989) [Pubmed]
  15. Calcium and calmodulin-dependent phosphorylation of a 62 kd protein induces microtubule depolymerization in sea urchin mitotic apparatuses. Dinsmore, J.H., Sloboda, R.D. Cell (1988) [Pubmed]
  16. A possible involvement of cya gene in the synthesis of cyclic guanosine 3':5'-monophosphate in E. coli. Shibuya, M., Takebe, Y., Kaziro, Y. Cell (1977) [Pubmed]
  17. Neurotransmitters increase cyclic nucleotides in postganglionic neurons: immunocytochemical demonstration. Kebabian, J.W., Blood, F.E., Steiner, A.L., Greengard, P. Science (1975) [Pubmed]
  18. Thrombin stimulation of guanosine 3',5'-monophosphate formation in murine neuroblastoma cells (clone N1E-115). Snider, R.M., Richelson, E. Science (1983) [Pubmed]
  19. Escherichia coli heat-stable toxin receptors in human colonic tumors. Carrithers, S.L., Parkinson, S.J., Goldstein, S., Park, P., Robertson, D.C., Waldman, S.A. Gastroenterology (1994) [Pubmed]
  20. Changes in cyclic nucleotide levels and contractile force in the isolated hypoxic rat heart during perfusion with glucagon. Busuttil, R.W., Paddock, R.J., Fisher, J.W., George, W.J. Circ. Res. (1976) [Pubmed]
  21. Control of Ca2+ in rod outer segment disks by light and cyclic GMP. George, J.S., Hagins, W.A. Nature (1983) [Pubmed]
  22. Prevention of natural motoneurone cell death by dibutyryl cyclic GMP. Weill, C.L., Greene, D.P. Nature (1984) [Pubmed]
  23. Cyclic nucleotides control a system which regulates Ca2+ sensitivity of platelet secretion. Knight, D.E., Scrutton, M.C. Nature (1984) [Pubmed]
  24. Primary structure and functional expression from complementary DNA of the rod photoreceptor cyclic GMP-gated channel. Kaupp, U.B., Niidome, T., Tanabe, T., Terada, S., Bönigk, W., Stühmer, W., Cook, N.J., Kangawa, K., Matsuo, H., Hirose, T. Nature (1989) [Pubmed]
  25. Role of guanylyl cyclase and cGMP-dependent protein kinase in long-term potentiation. Zhuo, M., Hu, Y., Schultz, C., Kandel, E.R., Hawkins, R.D. Nature (1994) [Pubmed]
  26. Endothelium-dependent relaxation in rat aorta may be mediated through cyclic GMP-dependent protein phosphorylation. Rapoport, R.M., Draznin, M.B., Murad, F. Nature (1983) [Pubmed]
  27. Cyclic GMP-activated conductance of retinal photoreceptor cells. Yau, K.W., Baylor, D.A. Annu. Rev. Neurosci. (1989) [Pubmed]
  28. Cyclic GMP can increase rod outer-segment light-sensitive current 10-fold without delay of excitation. Cobbs, W.H., Pugh, E.N. Nature (1985) [Pubmed]
  29. ATP mediates rapid reversal of cyclic GMP phosphodiesterase activation in visual receptor membranes. Liebman, P.A., Pugh, E.N. Nature (1980) [Pubmed]
  30. Sodium nitroprusside and other smooth muscle-relaxants increase cyclic GMP levels in rat ductus deferens. Schultz, K., Schultz, K., Schultz, G. Nature (1977) [Pubmed]
  31. Localization of nitric oxide synthase indicating a neural role for nitric oxide. Bredt, D.S., Hwang, P.M., Snyder, S.H. Nature (1990) [Pubmed]
  32. Glutamate stimulates inositol phosphate formation in striatal neurones. Sladeczek, F., Pin, J.P., Récasens, M., Bockaert, J., Weiss, S. Nature (1985) [Pubmed]
  33. Phosphorylation of lymphocyte nuclear acidic proteins: regulation by cyclic nucleotides. Johnson, E.M., Hadden, J.W. Science (1975) [Pubmed]
  34. Cyclic AMP and cyclic GMP may mediate opposite neuronal responses in the rat cerebral cortex. Stone, T.W., Taylor, D.A., Bloom, F.E. Science (1975) [Pubmed]
  35. Solution structure of the cGMP binding GAF domain from phosphodiesterase 5: insights into nucleotide specificity, dimerization, and cGMP-dependent conformational change. Heikaus, C.C., Stout, J.R., Sekharan, M.R., Eakin, C.M., Rajagopal, P., Brzovic, P.S., Beavo, J.A., Klevit, R.E. J. Biol. Chem. (2008) [Pubmed]
  36. Antagonistic pathways in neurons exposed to body fluid regulate social feeding in Caenorhabditis elegans. Coates, J.C., de Bono, M. Nature (2002) [Pubmed]
  37. Interleukin 1 activates soluble guanylate cyclase in human vascular smooth muscle cells through a novel nitric oxide-independent pathway. Beasley, D., McGuiggin, M. J. Exp. Med. (1994) [Pubmed]
  38. Endothelin (ET)-3 stimulates cyclic guanosine 3',5'-monophosphate production via ETB receptor by producing nitric oxide in isolated rat glomerulus, and in cultured rat mesangial cells. Owada, A., Tomita, K., Terada, Y., Sakamoto, H., Nonoguchi, H., Marumo, F. J. Clin. Invest. (1994) [Pubmed]
  39. The retinitis pigmentosa GTPase regulator, RPGR, interacts with the delta subunit of rod cyclic GMP phosphodiesterase. Linari, M., Ueffing, M., Manson, F., Wright, A., Meitinger, T., Becker, J. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  40. Endogenously produced nitric oxide increases tumor necrosis factor-alpha production in transfected human U937 cells. Yan, L., Wang, S., Rafferty, S.P., Wesley, R.A., Danner, R.L. Blood (1997) [Pubmed]
  41. IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation. Antl, M., von Brühl, M.L., Eiglsperger, C., Werner, M., Konrad, I., Kocher, T., Wilm, M., Hofmann, F., Massberg, S., Schlossmann, J. Blood (2007) [Pubmed]
  42. Atrial natriuretic peptide-initiated cGMP pathways regulate vasodilator-stimulated phosphoprotein phosphorylation and angiogenesis in vascular endothelium. Chen, H., Levine, Y.C., Golan, D.E., Michel, T., Lin, A.J. J. Biol. Chem. (2008) [Pubmed]
  43. Levels of cyclic nucleotides in autotransplanted 7, 12-dimethylbenz[a]anthracene-induced rat mammary tumors during their growth and regression. Lee, C. J. Natl. Cancer Inst. (1980) [Pubmed]
  44. Increased guanylate cyclase activity is associated with an increase in cyclic guanosine 3',5'-monophosphate in left ventricular hypertrophy. Sadoff, J.D., Scholz, P.M., Tse, J., Weiss, H.R. J. Clin. Invest. (1996) [Pubmed]
  45. Control and localization of rat adrenal cyclic guanosine 3', 5'-monophosphate. Comparison with adrenal cyclic adenosine 3', 5'-monophosphate. Whitley, T.H., Stowe, N.W., Ong, S.H., ey, R.L., Steiner, A.L. J. Clin. Invest. (1975) [Pubmed]
  46. Inhibition by atrial and brain natriuretic peptides of endothelin-1 secretion after stimulation with angiotensin II and thrombin of cultured human endothelial cells. Kohno, M., Yasunari, K., Yokokawa, K., Murakawa, K., Horio, T., Takeda, T. J. Clin. Invest. (1991) [Pubmed]
  47. Real-time patch-cram detection of intracellular cGMP reveals long-term suppression of responses to NO and muscarinic agonists. Trivedi, B., Kramer, R.H. Neuron (1998) [Pubmed]
 
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