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Chemical Compound Review:

AG-F-68892 tetradec-9-enoic acid

Synonyms: AG-F-89057, AG-J-56679, CTK1G7048, CTK5A1138, CTK6D6050, ...

Iguchi, K. et al., Rustenbeck, I. et al., Duan, Y.J. et al., Engle, C.C. et al., Jiang, J. et al.

Jiang, Wolk, Vessby,

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Disease relevance of Myristoleic acid

These results suggest that the extract and myristoleic acid may develop attractive new tools for the treatment of prostate cancer [1].

High impact information on Myristoleic acid

The percentage of 9c,11t-18:2 in both adipose tissue and in serum was strongly correlated with myristoleic acid (14:1) [2].
CONCLUSIONS: It was demonstrated that the extract from S. repens and myristoleic acid induces mixed cell death of apoptosis and necrosis in LNCaP cells [1].
Myristic acid (C14:0) in blood plasma and myristoleic acid (C14:1) in uterine tubal fluid were the only free fatty acids that had cyclic variation [3].
The PFK activity, but not the hexokinase activity, in hemolysates was clearly increased by a set of fatty acids, and myristoleic acid was again the most potent [4].
The structure-activity relationship and the inability of some of the effective fatty acids such as palmitoleic and myristoleic acid to be metabolized to eicosanoids suggest that Ca2+ release was induced by the fatty acids themselves and resulted from changes in the mitochondrial membrane bilayer structure [5].

Biological context of Myristoleic acid

Myristoleic acid, a cytotoxic component in the extract from Serenoa repens, induces apoptosis and necrosis in human prostatic LNCaP cells [1].

References

Myristoleic acid, a cytotoxic component in the extract from Serenoa repens, induces apoptosis and necrosis in human prostatic LNCaP cells. Iguchi, K., Okumura, N., Usui, S., Sajiki, H., Hirota, K., Hirano, K. Prostate (2001) [Pubmed]
Relation between the intake of milk fat and the occurrence of conjugated linoleic acid in human adipose tissue. Jiang, J., Wolk, A., Vessby, B. Am. J. Clin. Nutr. (1999) [Pubmed]
Certain physiochemical properties of uterine tubal fluid, follicular fluid, and blood plasma in the mare. Engle, C.C., Foley, C.W. Am. J. Vet. Res. (1975) [Pubmed]
Stimulatory effect of fatty acid treatment on glucose utilization in human erythrocytes. Duan, Y.J., Murase, S., Okuda, J., Tamura, A., Miwa, I. Biochim. Biophys. Acta (1997) [Pubmed]
Regulation of transmembrane ion transport by reaction products of phospholipase A2. II. Effects of arachidonic acid and other fatty acids on mitochondrial Ca2+ transport. Rustenbeck, I., Lenzen, S. Biochim. Biophys. Acta (1989) [Pubmed]

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