Gene Review:
HK1 - hexokinase 1
Homo sapiens
Synonyms:
Brain form hexokinase, HK I, HK1-ta, HK1-tb, HK1-tc, ...
- A novel (TA)n polymorphism in the hexokinase II gene: application to noninsulin-dependent diabetes mellitus in the Pima Indians. Ardehali, H., Tiller, G.E., Printz, R.L., Mochizuki, H., Prochazka, M., Granner, D.K. Hum. Genet. (1996)
- Mammalian hexokinases and their abnormal expression in cancer. Smith, T.A. Br. J. Biomed. Sci. (2000)
- Hexokinase isoenzymes in the diagnosis of gastric and esophageal neoplasms. Bassalyk, L.S., Ljubimova, N.V. Neoplasma (1987)
- Activities of key glycolytic enzymes in the brains of patients with Alzheimer's disease. Bigl, M., Brückner, M.K., Arendt, T., Bigl, V., Eschrich, K. Journal of neural transmission (Vienna, Austria : 1996) (1999)
- The potassium channel gene HK1 maps to human chromosome 11p14.1, close to the FSHB gene. Gessler, M., Grupe, A., Grzeschik, K.H., Pongs, O. Hum. Genet. (1992)
- Human beta-cell glucokinase. Dual role of Ser-151 in catalysis and hexose affinity. Xu, L.Z., Harrison, R.W., Weber, I.T., Pilkis, S.J. J. Biol. Chem. (1995)
- Enzyme activity patterns of energy supplying metabolism in the quadriceps femoris muscle (vastus lateralis): sedentary men and physically active men of different performance levels. Bass, A., Vondra, K., Rath, R., Vítek, V., Teisinger, J., Macková, E., Sprynarová, S., Malkovská, M. Pflugers Arch. (1976)
- Glycolytic enzymes from human autoptic brain cortex: normal aged and demented cases. Iwangoff, P., Armbruster, R., Enz, A., Meier-Ruge, W. Mech. Ageing Dev. (1980)
- Impaired glucose transport as a cause of decreased insulin-stimulated muscle glycogen synthesis in type 2 diabetes. Cline, G.W., Petersen, K.F., Krssak, M., Shen, J., Hundal, R.S., Trajanoski, Z., Inzucchi, S., Dresner, A., Rothman, D.L., Shulman, G.I. N. Engl. J. Med. (1999)
- Isoenzymes of hexokinase in human muscular dystrophy. Strickland, J.M., Ellis, D.A. Nature (1975)
- A new ATP-binding fold in actin, hexokinase and Hsc70. Holmes, K.C., Sander, C., Valencia, A. Trends Cell Biol. (1993)
- The effect of non-insulin-dependent diabetes mellitus and obesity on glucose transport and phosphorylation in skeletal muscle. Kelley, D.E., Mintun, M.A., Watkins, S.C., Simoneau, J.A., Jadali, F., Fredrickson, A., Beattie, J., Thériault, R. J. Clin. Invest. (1996)
- Impaired activity and gene expression of hexokinase II in muscle from non-insulin-dependent diabetes mellitus patients. Vestergaard, H., Bjørbaek, C., Hansen, T., Larsen, F.S., Granner, D.K., Pedersen, O. J. Clin. Invest. (1995)
- Glucose 6-phosphate release of wild-type and mutant human brain hexokinases from mitochondria. Skaff, D.A., Kim, C.S., Tsai, H.J., Honzatko, R.B., Fromm, H.J. J. Biol. Chem. (2005)
- Crystallization and preliminary X-ray analysis of human brain hexokinase. Aleshin, A.E., Zeng, C., Fromm, H.J., Honzatko, R.B. FEBS Lett. (1996)
- Cytotoxic activity of deferiprone, maltol and related hydroxyketones against human tumor cell lines. Yasumoto, E., Nakano, K., Nakayachi, T., Morshed, S.R., Hashimoto, K., Kikuchi, H., Nishikawa, H., Kawase, M., Sakagami, H. Anticancer Res. (2004)
- Malarial parasite hexokinase and hexokinase-dependent glutathione reduction in the Plasmodium falciparum-infected human erythrocyte. Roth, E.F. J. Biol. Chem. (1987)
- Expression of hexokinase 1 and hexokinase 2 in mammary tissue of nonlactating and lactating rats: evaluation by RT-PCR. Kaselonis, G.L., McCabe, E.R., Gray, S.M. Mol. Genet. Metab. (1999)
- Shared synteny between human chromosome 10 and chromosome 1 of the marsupial tammar wallaby, Macropus eugenii. Spurdle, A.B., Maccarone, P., Toder, R., Wilcox, S.A., Graves, J.A. Cytogenet. Cell Genet. (1997)
- Identification of the cDNA for human red blood cell-specific hexokinase isozyme. Murakami, K., Piomelli, S. Blood (1997)
- Hexokinase II: the integration of energy metabolism and control of apoptosis. Pastorino, J.G., Hoek, J.B. Current medicinal chemistry. (2003)
- An isozyme of hexokinase specific for the human red blood cell (HKR). Murakami, K., Blei, F., Tilton, W., Seaman, C., Piomelli, S. Blood (1990)
- The voltage-dependent anion channel-1 modulates apoptotic cell death. Zaid, H., Abu-Hamad, S., Israelson, A., Nathan, I., Shoshan-Barmatz, V. Cell Death Differ. (2005)
- Biologic correlates of (18)fluorodeoxyglucose uptake in human breast cancer measured by positron emission tomography. Bos, R., van Der Hoeven, J.J., van Der Wall, E., van Der Groep, P., van Diest, P.J., Comans, E.F., Joshi, U., Semenza, G.L., Hoekstra, O.S., Lammertsma, A.A., Molthoff, C.F. J. Clin. Oncol. (2002)
- Isoenzyme pattern and subcellular localization of hexokinases in human breast cancer and nonpathological breast tissue. Gudnason, V., Ingvarsson, S., Jonasdottir, A., Andresdottir, V., Egilsson, V. Int. J. Cancer (1984)
- Human genes encoding the voltage-dependent anion channel (VDAC) of the outer mitochondrial membrane: mapping and identification of two new isoforms. Blachly-Dyson, E., Baldini, A., Litt, M., McCabe, E.R., Forte, M. Genomics (1994)
- A population association study of four candidate genes (hexokinase II, glucagon-like peptide-1 receptor, fatty acid binding protein-2, and apolipoprotein C-II) with type 2 diabetes and impaired glucose tolerance in Japanese subjects. Yagi, T., Nishi, S., Hinata, S., Murakami, M., Yoshimi, T. Diabet. Med. (1996)
- Frequency of glucose-6-phosphate dehydrogenase, pyruvate kinase and hexokinase deficiency in the Saudi population. el-Hazmi, M.A., Al-Swailem, A.R., Al-Faleh, F.Z., Warsy, A.S. Hum. Hered. (1986)
- Evaluation of the role of hexokinase type II in cellular proliferation and apoptosis using human hepatocellular carcinoma cell lines. Ahn, K.J., Hwang, H.S., Park, J.H., Bang, S.H., Kang, W.J., Yun, M., Lee, J.D. J. Nucl. Med. (2009)
- Gaucher disease. III. Substrate specificity of glucocerebrosidase and the use of nonlabeled natural substrates for the investigation of patients. Choy, F.Y., Davidson, R.G. Am. J. Hum. Genet. (1980)
- Decreased muscle glucose transport/phosphorylation is an early defect in the pathogenesis of non-insulin-dependent diabetes mellitus. Rothman, D.L., Magnusson, I., Cline, G., Gerard, D., Kahn, C.R., Shulman, R.G., Shulman, G.I. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Cellular mechanisms of insulin resistance in humans. Shulman, G.I. Am. J. Cardiol. (1999)
- Study on ATP-generating system and related hexokinase activity in mitochondria isolated from undifferentiated or differentiated HT29 adenocarcinoma cells. Gauthier, T., Denis-Pouxviel, C., Paris, H., Murat, J.C. Biochim. Biophys. Acta (1989)
- Hexose transporters GLUT1 and GLUT3 are colocalized with hexokinase I in caveolae microdomains of rat spermatogenic cells. Rauch, M.C., Ocampo, M.E., Bohle, J., Amthauer, R., Yáñez, A.J., Rodríguez-Gil, J.E., Slebe, J.C., Reyes, J.G., Concha, I.I. J. Cell. Physiol. (2006)
- In self-defence: hexokinase promotes voltage-dependent anion channel closure and prevents mitochondria-mediated apoptotic cell death. Azoulay-Zohar, H., Israelson, A., Abu-Hamad, S., Shoshan-Barmatz, V. Biochem. J. (2004)
- Peroxisome Function Regulates Growth on Glucose in the Basidiomycete Fungus Cryptococcus neoformans. Idnurm, A., Giles, S.S., Perfect, J.R., Heitman, J. Eukaryotic Cell (2007)
- Elevated expression of hexokinase II protects human lung epithelial-like A549 cells against oxidative injury. Ahmad, A., Ahmad, S., Schneider, B.K., Allen, C.B., Chang, L.Y., White, C.W. Am. J. Physiol. Lung Cell Mol. Physiol. (2002)
- Importance of cell aggregation for expression of liver functions and regeneration demonstrated with primary cultured hepatocytes. Yuasa, C., Tomita, Y., Shono, M., Ishimura, K., Ichihara, A. J. Cell. Physiol. (1993)
- Red cell metabolic alterations in postnatal life in term infants: glycolytic enzymes and glucose-6-phosphate dehydrogenase. Travis, S.F., Kumar, S.P., Paez, P.C., Delivoria-Papadopoulos, M. Pediatr. Res. (1980)
- Glutathione recycling and antioxidant enzyme activities in erythrocytes of term and preterm newborns at birth. Frosali, S., Di Simplicio, P., Perrone, S., Di Giuseppe, D., Longini, M., Tanganelli, D., Buonocore, G. Biol. Neonate (2004)
- Mononuclear leukocytes from obese patients with type II diabetes have reduced activity of hexokinase, 6-phosphofructokinase and glucose-6-phosphate dehydrogenase. Muggeo, M., Moghetti, P., Querena, M., Cacciatori, V., Zoppini, G., Zenere, M., Tosi, F., Travia, D., Bonora, E. Horm. Metab. Res. (1993)