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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Plasma


Psychiatry related information on Plasma


High impact information on Plasma

  • The prolonged thromboplastin times were corrected by normal plasma and by normal plasma adsorbed with celite, but there was no mutual correction between plasmas of the patients [8].
  • We show here, however, that song learning and early phases of the development of singing both take place in castrated male birds with no significant levels of testosterone in their blood plasma [9].
  • Human apolipoprotein E, a blood plasma protein, mediates the transport and uptake of cholesterol and lipid by way of its high affinity interaction with different cellular receptors, including the low-density lipoprotein (LDL) receptor [10].
  • The proposed formula is more precise for plasmas or sera with a TG concentration within the normal range [11].
  • The shock plasmas revealed a strong LPS-inhibitory capacity that was largely absent in plasmas from 10 meningococcal patients without shock since the median levels of PCA, TNF-alpha, and IL-6 increased from 5, 0, and 0% to 135, 51, and 73%, respectively, after boosting with 2,500 pg/ml Nm-LPS [12].

Chemical compound and disease context of Plasma

  • The observed impairment of hepatic GABA uptake or catabolism by the diseased liver would be expected to contribute to increased GABA levels in peripheral blood plasma in liver failure [13].
  • The venom factor acts on formaldehyde-fixed platelets and is effective with decalcified, heparinized, and afibrinogenemic plasmas but not with severe von Willebrand disease plasmas or with normal plasmas in which the von Willebrand factor has been neutralized by specific antibodies [14].
  • Immunoblotting of a series of C2 deletion polypeptides, expressed in Escherichia coli, with inhibitor plasmas showed that the epitopes for human inhibitors consist of a common core of amino acid residues 2248 through 2312 with differing extensions for individual inhibitors [15].
  • Passage of five citrated lupus anticoagulant plasmas through a prothrombin affinity column in the absence of added calcium and phospholipid removed most of the activity prolonging the dRVVT of normal plasma, and IgG in the pass-through plasma no longer bound to PS in the presence of prothrombin and calcium ions [16].
  • The cause of such calcification is unknown, but potential pathogenetic factors include hyperparathyroidism, calcium administered during and following surgery, renal failure, acid-base changes and citrate in fresh frozen plasma [17].

Biological context of Plasma


Anatomical context of Plasma

  • Decreasing levels of IL-10 in serially collected shock plasmas were directly related to increasing monocyte responsiveness after Nm-LPS boosting [12].
  • Inhibitor antigen concentrations were found to be very high in seminal plasma (greater than 200 mg/liter), more than 40 times the concentration of PCI found in blood plasma [23].
  • The mass of dermatan sulfate in pregnancy and umbilical cord plasmas was increased over adult control plasma by 0.20 micrograms/ml (53%) and 0.29 micrograms/ml (76%), respectively [24].
  • This confirmed the presence of an anticoagulant active dermatan sulfate proteoglycan circulating in the plasmas of pregnant women at term and fetuses at delivery [24].
  • The ratio of aminopyrine concentration in the gastric juice and blood plasma was not significantly changed by GH-RIH, indicating that the reduction in mucosal blood flow was secondary to an inhibition of gastric secretion [25].

Associations of Plasma with chemical compounds

  • Injection of heparin after 10 or 20 min led to an immediate release of all sequestered 125I-EC-SOD C back to the blood plasma [26].
  • Crossed immunoelectrophoresis of patients' plasmas and studies of partially purified patient prothrombin suggested the presence of a relatively homogeneous species of dysfunctional prothrombin, distinct from the heterologous species found in the plasma of warfarin-treated persons [27].
  • No Factor IX antigen could be detected in patients' plasmas by a non-calcium-requiring monoclonal anti-Factor IX antibody (less than 2 ng/ml) [28].
  • Characterization of remnants produced during the metabolism of triglyceride-rich lipoproteins of blood plasma and intestinal lymph in the rat [29].
  • The glycosaminoglycan-containing fraction of plasma was isolated and an assay for anticoagulant dermatan sulfate confirmed its presence in both pregnancy and cord plasmas but minimal activity in adult plasma [24].

Gene context of Plasma

  • IL-4 and TGF-beta were not detected in shock plasmas [12].
  • An assay was developed for the measurement of human protein C inhibitor antigen (PCI) in blood plasma and other biological fluids [23].
  • ADAMTS13 activity was similar in all 4 type I VWD cryodepleted plasmas and comparable to a normal control plasma [30].
  • All TTP plasmas contained antibodies directed against the cysteine-rich spacer (cys-rich/spacer) domain of ADAMTS13 [31].
  • Thus, the inhibitor appeared to interfere with these clotting factor assays, possibly by inactivating PTA in the substrate plasmas in the test system [32].

Analytical, diagnostic and therapeutic context of Plasma


  1. Isolation and properties of an abnormal Hageman factor (Factor XII) molecule in a cross-reacting material-positive hageman trait plasma. Saito, H., Scialla, S.J. J. Clin. Invest. (1981) [Pubmed]
  2. High-density lipoprotein enhancement of anticoagulant activities of plasma protein S and activated protein C. Griffin, J.H., Kojima, K., Banka, C.L., Curtiss, L.K., Fernández, J.A. J. Clin. Invest. (1999) [Pubmed]
  3. Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathways. Werstuck, G.H., Lentz, S.R., Dayal, S., Hossain, G.S., Sood, S.K., Shi, Y.Y., Zhou, J., Maeda, N., Krisans, S.K., Malinow, M.R., Austin, R.C. J. Clin. Invest. (2001) [Pubmed]
  4. Deficiency of protein C inhibitor in combined factor V/VIII deficiency disease. Marlar, R.A., Griffin, J.H. J. Clin. Invest. (1980) [Pubmed]
  5. Meningococcal septicaemia in a C6-deficient patient and effects of plasma transfusion on lipopolysaccharide release. Lehner, P.J., Davies, K.A., Walport, M.J., Cope, A.P., Würzner, R., Orren, A., Morgan, B.P., Cohen, J. Lancet (1992) [Pubmed]
  6. Relaxin in peripheral plasma of boars during development, copulation, after administration of hCG and after castration. Juang, H.H., Musah, A.I., Schwabe, C., Ford, J.J., Anderson, L.L. J. Reprod. Fertil. (1996) [Pubmed]
  7. Screening INR deviation of local prothrombin time systems. Poller, L. J. Clin. Pathol. (1998) [Pubmed]
  8. The Passovoy defect: further characterization of a hereditary hemorrhagic diathesis. Hougie, C., Mc Pherson, R.A., Brown, J.E., Lakin-Thomas, P.L., Melaragno, A., Aronson, L., Baugh, R.F. N. Engl. J. Med. (1978) [Pubmed]
  9. The role of sex steroids in the acquisition and production of birdsong. Marler, P., Peters, S., Ball, G.F., Dufty, A.M., Wingfield, J.C. Nature (1988) [Pubmed]
  10. Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein E. Wilson, C., Wardell, M.R., Weisgraber, K.H., Mahley, R.W., Agard, D.A. Science (1991) [Pubmed]
  11. A comparison of methods for the estimation of plasma low- and very low-density lipoprotein cholesterol. The Lipid Research Clinics Prevalence Study. DeLong, D.M., DeLong, E.R., Wood, P.D., Lippel, K., Rifkind, B.M. JAMA (1986) [Pubmed]
  12. Net inflammatory capacity of human septic shock plasma evaluated by a monocyte-based target cell assay: identification of interleukin-10 as a major functional deactivator of human monocytes. Brandtzaeg, P., Osnes, L., Ovstebø, R., Joø, G.B., Westvik, A.B., Kierulf, P. J. Exp. Med. (1996) [Pubmed]
  13. Uptake and catabolism of gamma-aminobutyric acid by the isolated perfused rat liver. Ferenci, P., Stehle, T., Ebner, J., Schmid, R., Häussinger, D. Gastroenterology (1988) [Pubmed]
  14. Venom coagglutinin: an activator of platelet aggregation dependent on von Willebrand factor. Read, M.S., Shermer, R.W., Brinkhous, K.M. Proc. Natl. Acad. Sci. U.S.A. (1978) [Pubmed]
  15. Some factor VIII inhibitor antibodies recognize a common epitope corresponding to C2 domain amino acids 2248 through 2312, which overlap a phospholipid-binding site. Scandella, D., Gilbert, G.E., Shima, M., Nakai, H., Eagleson, C., Felch, M., Prescott, R., Rajalakshmi, K.J., Hoyer, L.W., Saenko, E. Blood (1995) [Pubmed]
  16. Functional and binding studies of the roles of prothrombin and beta 2-glycoprotein I in the expression of lupus anticoagulant activity. Permpikul, P., Rao, L.V., Rapaport, S.I. Blood (1994) [Pubmed]
  17. Ectopic soft tissue calcium deposition following liver transplantation. Munoz, S.J., Nagelberg, S.B., Green, P.J., Angstadt, J.D., Yang, S.L., Jarrell, B.E., Maddrey, W.C. Hepatology (1988) [Pubmed]
  18. Renin lowers blood-pressure. Gordon, D.B. Lancet (1978) [Pubmed]
  19. Antioxidant defenses and lipid peroxidation in human blood plasma. Frei, B., Stocker, R., Ames, B.N. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  20. Demonstration and mode of action of an inhibitor for activated Hageman factor (factor XIIa) of the intrinsic blood coagulation pathway from Schistosoma mansoni. Tsang, V.C., Damian, R.T. Blood (1977) [Pubmed]
  21. Plasma vitronectin polymorphism in normal subjects and patients with disseminated intravascular coagulation. Conlan, M.G., Tomasini, B.R., Schultz, R.L., Mosher, D.F. Blood (1988) [Pubmed]
  22. Stimulation of microsomal prostaglandin synthesis by a blood plasma constituent which augments autoregulation and maintenance of vascular tone in isolated rabbit hearts. Moretti, R.L., Abraham, S. Circ. Res. (1978) [Pubmed]
  23. Protein C inhibitor in human body fluids. Seminal plasma is rich in inhibitor antigen deriving from cells throughout the male reproductive system. Laurell, M., Christensson, A., Abrahamsson, P.A., Stenflo, J., Lilja, H. J. Clin. Invest. (1992) [Pubmed]
  24. An anticoagulant dermatan sulfate proteoglycan circulates in the pregnant woman and her fetus. Andrew, M., Mitchell, L., Berry, L., Paes, B., Delorme, M., Ofosu, F., Burrows, R., Khambalia, B. J. Clin. Invest. (1992) [Pubmed]
  25. Effect of growth hormone release-inhibiting hormone on gastric secretion, mucosal blood flow, and serum gastrin. Konturek, S.J., Tasler, J., Cieszkowski, M., Coy, D.H., Schally, A.V. Gastroenterology (1976) [Pubmed]
  26. Plasma clearance of human extracellular-superoxide dismutase C in rabbits. Karlsson, K., Marklund, S.L. J. Clin. Invest. (1988) [Pubmed]
  27. Studies on a family with combined functional deficiencies of vitamin K-dependent coagulation factors. Goldsmith, G.H., Pence, R.E., Ratnoff, O.D., Adelstein, D.J., Furie, B. J. Clin. Invest. (1982) [Pubmed]
  28. Partial factor IX protein in a pedigree with hemophilia B due to a partial gene deletion. Bray, G.L., Thompson, A.R. J. Clin. Invest. (1986) [Pubmed]
  29. Characterization of remnants produced during the metabolism of triglyceride-rich lipoproteins of blood plasma and intestinal lymph in the rat. Mjos, O.D., Faergeman, O., Hamilton, R.L., Havel, R.J. J. Clin. Invest. (1975) [Pubmed]
  30. An amino acid polymorphism in von Willebrand factor correlates with increased susceptibility to proteolysis by ADAMTS13. Bowen, D.J., Collins, P.W. Blood (2004) [Pubmed]
  31. Epitope mapping of ADAMTS13 autoantibodies in acquired thrombotic thrombocytopenic purpura. Klaus, C., Plaimauer, B., Studt, J.D., Dorner, F., Lämmle, B., Mannucci, P.M., Scheiflinger, F. Blood (2004) [Pubmed]
  32. A unique precipitating autoantibody against plasma thromboplastin antecedent associated with multiple apparent plasma clotting factor deficiencies in a patient with systemic lupus erythematosus. Poon, M.C., Saito, H., Koopman, W.J. Blood (1984) [Pubmed]
  33. Radioimmunoassay of human arginine-rich apolipoprotein, apoprotein E. Concentration in blood plasma and lipoproteins as affected by apoprotein E-3 deficiency. Havel, R.J., Kotite, L., Vigne, J.L., Kane, J.P., Tun, P., Phillips, N., Chen, G.C. J. Clin. Invest. (1980) [Pubmed]
  34. Plasma dermatan sulfate proteoglycan in a patient on chronic hemodialysis. Delorme, M.A., Saeed, N., Sevcik, A., Mitchell, L., Berry, L., Johnston, M., Andrew, M. Blood (1993) [Pubmed]
  35. Adrenoleukodystrophy: a correlation between saturated very long-chain fatty acids in mononuclear cells and phenotype. Antoku, Y., Koike, F., Ohtsuka, Y., Sakai, T., Tsukamoto, K., Nagara, H., Iwashita, H., Goto, I. Ann. Neurol. (1991) [Pubmed]
  36. Enzymatic inactivation of N-nitroso compounds in murine blood plasma. Brundrett, R.B., Aukerman, S.L. Cancer Res. (1985) [Pubmed]
  37. Splenic uptake of immune complexes in man is complement-dependent. Davies, K.A., Erlendsson, K., Beynon, H.L., Peters, A.M., Steinsson, K., Valdimarsson, H., Walport, M.J. J. Immunol. (1993) [Pubmed]
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