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Chemical Compound Review:

Nebularine (2R,3S,4R,5R)-2- (hydroxymethyl)-5-purin-9...

Synonyms: Purinosine, Ribosylpurine, Nebularin E), Nebularin(E), SureCN93409, ...

Camici, M. et al., Iida, T. et al., Melki, R. et al., Osborne, W.R. et al.

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Disease relevance of Purine ribonucleoside

The repair enzymes to oxidative DNA damage, oxidized purine-nucleoside triphosphatase (hMTH1) and a mitochondrial type of 8-oxoguanine DNA glycosylase (hOGG1-2a) in brain tumors and neurons of Alzheimer's disease, were previously reported [1].

High impact information on Purine ribonucleoside

Purine nucleoside phosphorylase (PNP; purine-nucleoside orthophosphate ribosyltransferase, EC 2.4.2.1) deficiency is an inherited disorder associated with a severe immune defect that is fatal [2].
Continuous monitoring of Pi release following nucleotide hydrolysis in actin or tubulin assembly using 2-amino-6-mercapto-7-methylpurine ribonucleoside and purine-nucleoside phosphorylase as an enzyme-linked assay [3].
A variant clone of cultured chinese hamster lung fibroblasts (V79), selected for resistance to 8-azaguanine (V79 azagrst), although lacking hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8), is able to convert hypoxanthine into IMP via purine-nucleoside phosphorylase (EC 2.4.2.1) and nucleoside kinase [4].

References

Defense mechanism to oxidative DNA damage in glial cells. Iida, T., Furuta, A., Nakabeppu, Y., Iwaki, T. Neuropathology : official journal of the Japanese Society of Neuropathology. (2004) [Pubmed]
Design of vectors for efficient expression of human purine nucleoside phosphorylase in skin fibroblasts from enzyme-deficient humans. Osborne, W.R., Miller, A.D. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
Continuous monitoring of Pi release following nucleotide hydrolysis in actin or tubulin assembly using 2-amino-6-mercapto-7-methylpurine ribonucleoside and purine-nucleoside phosphorylase as an enzyme-linked assay. Melki, R., Fievez, S., Carlier, M.F. Biochemistry (1996) [Pubmed]
Alpha-5-phosphoribosyl-1-pyrophosphate-independent salvage of purines in cultured Chinese hamster lung fibroblasts. Camici, M., Mura, U., Cellini, F., Del Corso, A., Turchi, G., Ipata, P.L. Arch. Biochem. Biophys. (1988) [Pubmed]

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