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Chemical Compound Review

COFFEE EXTRACT     furan;1-methylpyridine-5- carboxylate;...

Synonyms: LS-2498, AC1OA83A, EINECS 283-481-1, Extract of coffee, Coffee bean extract, ...
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Disease relevance of Coffee


Associations of Coffee with other chemical compounds

  • After adjusting for age and sex, serum uric acid level associated with coffee intake of 4 to 5 and >/=6 cups daily was lower than that associated with no intake by 0.26 mg/dl (95% confidence interval [95% CI] 0.11, 0.41) and 0.43 mg/dl (95% CI 0.23, 0.65; P for trend < 0.001), respectively [4].
  • Common polymorphisms in genes involved in the metabolism of caffeine, catecholamines, homocysteine, and cholesterol can modulate the effect of coffee intake on cardiovascular parameters [5].


  1. Transient exposure to coffee as a trigger of a first nonfatal myocardial infarction. Baylin, A., Hernandez-Diaz, S., Kabagambe, E.K., Siles, X., Campos, H. Epidemiology (2006) [Pubmed]
  2. Coffee drinking and hepatocellular carcinoma risk: a meta-analysis. Bravi, F., Bosetti, C., Tavani, A., Bagnardi, V., Gallus, S., Negri, E., Franceschi, S., La Vecchia, C. Hepatology (2007) [Pubmed]
  3. Coffee intake and incidence of hypertension. Uiterwaal, C.S., Verschuren, W.M., Bueno-de-Mesquita, H.B., Ocké, M., Geleijnse, J.M., Boshuizen, H.C., Peeters, P.H., Feskens, E.J., Grobbee, D.E. Am. J. Clin. Nutr. (2007) [Pubmed]
  4. Coffee, tea, and caffeine consumption and serum uric acid level: the third national health and nutrition examination survey. Choi, H.K., Curhan, G. Arthritis Rheum. (2007) [Pubmed]
  5. Acute and long-term cardiovascular effects of coffee: implications for coronary heart disease. Riksen, N.P., Rongen, G.A., Smits, P. Pharmacol. Ther. (2009) [Pubmed]
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